Examinando por Materia "Dronabinol"

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    La validación de una técnica analítica para determinar la potencia de cannabidiol, tetrahidrocannabinol y cannabigerol en aceite por cromatografía líquida de alto rendimiento en laboratorio farmacéutico. Lima – 2022
    (Universidad Privada Norbert Wiener, 2023-02-02) Lujan Pucuhuaylas, Hairo Enrique; Meza Melo, Ximena Rosario; Félix Véliz, Luis Miguel Visitación
    The objective of this research was to evaluate the validation of an analytical technique, according to international standards, for determining the potency of cannabidiol (CBD), tetrahydrocannabinol (THC), and cannabigerol (CBG) in oil using high-performance liquid chromatography (HPLC) in a pharmaceutical laboratory. Methodology: The validation of the analytical method was deductive, quantitative, applied, and non-experimental in design, observational, and cross-sectional. Results: The RSD for instrumental precision of peak areas and retention times was less than 2.0%. For accuracy, recoveries of 99.7%, 100.6%, and 100.7% were obtained for the analytes CBD, THC, and CBG, respectively. For intermediate precision, the RSD between analysts was measured, yielding RSD values of 1.0, 1.1, and 0.9 for CBD, THC, and CBG, respectively. For the linearity tests of the method and system, correlation (r) and determination coefficients (r²) of 0.999 were obtained for all three analytes. Conclusion: The implementation of the analytical method for determining the potency of CBD, THC, and CBG in oil through high-performance liquid chromatography (HPLC) meets the required statistical results, ensuring reliability and quality for the intended uses.