Examinando por Materia "Drug Hypersensitivity"

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    Effectiveness of desensitization protocols in hypersensitivity reactions caused by cytotoxic antineoplastic agents
    (Universidad Privada Norbert Wiener, 2017-11-12) Avalos Molina, Ana María; Ucharo Capcha, Jennifer Stefany; Bonilla Asalde, César Antonio
    Objective: To systematize the evidence regarding the effectiveness of desensitization protocols in reducing hypersensitivity reactions caused by cytotoxic antineoplastic agents. Methodology: This is a systematic review that included articles considering adult patients as study samples. Ten articles were selected, of which 40% were from studies in the United States, one from Greece (10%), Japan (10%), Spain (20%), and Korea (20%). Regarding research designs, we included one systematic review, four analytical cross-sectional studies, one cohort, two case-control studies, and two cross-sectional descriptive studies. The selected articles underwent a critical reading, and the quality of evidence and strength of recommendation were evaluated using the GRADE system. Results: Of the 10 articles reviewed, 90% of the studies considered the use of desensitization protocols to be 100% effective in reducing hypersensitivity reactions, as patients did not present hypersensitivity upon reintroduction of taxanes and platinum salts, completing their therapeutic dose. Conclusions: There is high efficacy in the use of desensitization protocols to reduce hypersensitivity reactions in patients treated with cytotoxic antineoplastic agents such as taxanes and platinum salts, allowing patients the possibility to complete the treatment.