Examinando por Materia "Drug Interactions"

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Caracterización de interacciones medicamentosas en pacientes hospitalizados con patologías cardiovasculares del "Hospital Nacional Guillermo Almenara Irigoyen – EsSalud", periodo julio–noviembre 2017
(Universidad Privada Norbert Wiener, 2018-08-20) Rodriguez Natividad, Mariela Elizabeth; Tuano Condori, Doris Janeth; Moreno Exebio, Luis Enrique
This study was conducted with the purpose of characterizing drug–drug interactions (DDIs) in hospitalized patients with cardiovascular diseases at the Hospital Nacional Guillermo Almenara Irigoyen – EsSalud between July and November 2017. Data were collected by reviewing medical prescriptions from the clinical records of 139 hospitalized patients with these pathologies. A descriptive, prospective, and longitudinal study design was applied. After applying the selection criteria, 127 patients (91%) were found to present drug–drug interactions. Of these, 101 (73%) were male and 38 (27%) were female; 93 patients (67%) were older than 60 years. Regarding the number of prescribed drugs, 25 patients (18%) were taking six medications. Antiplatelet agents (acetylsalicylic acid and clopidogrel) accounted for 192 prescriptions (39.2%). According to the type of interaction, 48 (20%) were pharmacokinetic and 197 (80%) pharmacodynamic; the most frequent association was clopidogrel–enoxaparin, with 39 cases (15.9%). Potential interactions were identified in 245 cases (98.8%) and actual interactions in 3 cases (1.2%). With respect to the time of occurrence, 71 interactions (29%) were classified as late, while in terms of severity, 166 (68%) were considered severe. The search for drug–drug interactions was performed using the Micromedex, Drug Interaction Checker, and Medscape databases. In conclusion, 67% of the study population were aged 60 years or older and did present drug–drug interactions, the majority of whom were male. Most interactions (81%, n=147) were pharmacodynamic, and among the cardiovascular pathologies, heart failure accounted for 31.4% (n=77) of the cases.
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Caracterización de interacciones medicamentosas potenciales en las prescripciones médicas atendidas a pacientes ambulatorios
(Universidad Privada Norbert Wiener, 2015) Arce Tintaya, Abner; Castro Luna, Rosa Chabely; Martínez Vargas Araníbar, Humberto Nazario
The objective of this study was to determine the characterization of potential drug interactions present in medical prescriptions attended to outpatients at the InkaFarma pharmacy located in Flora Tristán, La Molina district, between April and June 2014. A descriptive, cross-sectional, retrospective, and observational study was designed for this purpose. Medical prescriptions from various specialties were considered. According to the inclusion criteria, 191 medical prescriptions were analyzed. It was found that 67% did not present drug interactions, while 33% did. Regarding sex distribution, 41% of the population were male and 58% female; 35 females and 28 males presented drug interactions. Concerning the onset of interactions, the majority (77%) were undocumented, 18% had a slow onset, and 6% had a rapid onset. Regarding the severity, 81% of the interactions were moderate, 10% were major, and 9% were minor. By mechanism of action, 48% were pharmacodynamic and 37% were pharmacokinetic. Regarding age groups, the majority of the population were adults (83 patients), followed by young people (81 patients). The specialty with the highest number of drug interactions was internal medicine, with 17 cases out of 88 prescriptions attended.
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Cumplimiento de buenas practicas de prescripción y determinacion de interacciones medicamentosas con ivermectina en tiempos de COVID-19 en recetas médicas atendidas en la farmacia del Centro de Salud Unidad Vecinal N° 3 – mayo a diciembre 2020
(Universidad Privada Norbert Wiener, 2022-04-27) Curo Guevara, Sara Elizabeth; Mendoza Baldeón, Gonzalina; Félix Véliz, Luis Miguel Visitación
The global COVID-19 health emergency has created a need to find medications to help treat and combat it. In this context, Ivermectin was established as an option frequently recommended by doctors, making it essential that it be correctly prescribed and dispensed to patients. Objective: To determine drug interactions in ivermectin prescriptions filled at the pharmacy of Neighborhood Health Center No. 3 from May to December 2020, in compliance with good prescribing practices. Methodology: This was a descriptive study, supported by the use of forms for data collection from 204 prescriptions at the Health Center's pharmacy. Results: Prescriber data was completed in over 95% of prescriptions, and patient data had even higher completion rates, always exceeding 97%. Medication data completion surpassed 98%. Drug interactions were found in 81 prescriptions, all of which were of moderate severity with a potential clinical manifestation. No pharmacological follow-up was performed to determine a real clinical manifestation. Furthermore, all 81 (100%) of the interactions were potential pharmacokinetic interactions, and none were potential pharmacodynamic interactions. Conclusion: Although good prescribing practices were well implemented, a key finding is that potential drug interactions were present in the patients' treatments, as identified through information searches.
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Cumplimiento de las recetas medicas con respecto a los aspectos legales y farmacologicos atendidas en Boticas ByS en el distrito de San Isidro julio 2017–febrero 2018
(Universidad Privada Norbert Wiener, 2020-09-15) Durand Quintanilla, Josselyn; Caldas Herrera, Emma
The objective of the study was to evaluate the legal and pharmacological aspects of medical prescriptions filled for patients at the Boticas y Salud drugstores in the San Isidro district from July 2017 to February 2018. Methodology: The design was observational and cross-sectional. Out of a population of 870 medical prescriptions, a sample of 585 was selected. All of these prescriptions were evaluated for Good Prescribing Practices (GPP) across the dimensions of prescriber data, patient data, and medication data. Additionally, 281 medical prescriptions were used for the identification of drug interactions and the evaluation of therapeutic indication. Results: The medical prescriptions filled did not comply with the legal and pharmacological aspects. Compliance for prescriber data was nearly total at 90.8%. Compliance for patient data was significantly lacking at 15.2%, and compliance for medication data was similarly lacking at 9.2%. Regarding therapeutic indication data, 5% had an incorrect dose, 8.3% had an incorrect frequency, and 15.4% had an incorrect treatment duration. For drug interactions, 65.9% were pharmacodynamic, 26.4% were pharmacokinetic, and 12.5% were of unknown type. By severity, 9.2% were major, 85.1% were moderate, and 4.9% were minor. Conclusion: The medical prescriptions filled do not comply with Good Prescribing Practices. Furthermore, while the majority comply with therapeutic indication correspondence, drug interactions are present in 65.9% of the total prescriptions filled at Boticas y Salud in the San Isidro district.
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Efectos colaterales e interacciones de los antibióticos en la prescripción médica de pacientes con infección respiratoria que acuden a la botica Los Olivos de Lurín en el periodo 2023
(Universidad Privada Norbert Wiener, 2024-11-04) Vargas Pascual, Sandi Veronica; Vega Gomero, Pamela Olived; Parreño Tipián, Juan Manuel
Globally, an increase in antibiotic consumption has been observed worldwide. The objective of this study is to determine the relationship between the side effects and interactions of antibiotics prescribed by a doctor in patients with respiratory infection who come to the Olivos de Lurín pharmacy. The method has a non-experimental design, quantitative approach, descriptive, correlational, retrospective and transversal level. The sample is made up of 150 patients with a diagnosis of respiratory infection who go to the pharmacy with a medical prescription. The instrument used was a survey. The result was that the majority, 42.48%, are between 31 and 40 years old. Regarding gender, 57.52% are men and 42.48% are women. Regarding the use of medications, 28.32% use Penicillin, 26.55% use Cephalosporins, and only 1.77% use Sulfonamides and Amphenicols. Regarding pharmacodynamics, 75.22% mention synergism, 18.58% mention antagonism. In relation to the pharmacokinetic interaction, 36.28% of respondents felt the interaction in the distribution process, while 6.19% indicated that it never occurred. Regarding the clinical relevance of the interactions, 79.65% indicate that they had a serious effect, and 7.08% mention that they never felt the interaction according to the clinical relevance. It is concluded that there is a high relationship between the side effects and interactions of prescription antibiotics in patients with respiratory infection who go to the Olivos de Lurín pharmacy.
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Estudio de análisis de las interacciones medicamentosas potenciales según grupo etario en pacientes hospitalizados de trabajos de investigación realizadas en universidades peruanas
(Universidad Privada Norbert Wiener, 2017-12-12) Arias Chavez, Carito Magalli; Torres Veliz, Ernesto Raúl
A drug interaction is defined as any modification that occurs in pharmacokinetics. Pharmacological interactions can be understood as quantitative or qualitative modifications or alterations of a drug’s effect. Beneficial interactions occur when an increase in therapeutic effectiveness is observed, while adverse interactions occur when therapeutic efficacy decreases, as in the case of quinidine, which reduces the analgesic effect of codeine. External interactions refer to physicochemical incompatibilities in intravenous administration mixtures, such as precipitation, whereas internal interactions occur in the gastrointestinal tract, in the liver, or at the drug’s site of action. According to their mechanism of production, drug interactions can be classified as pharmaceutical, pharmacodynamic, or pharmacokinetic. Pharmaceutical interactions involve physicochemical incompatibilities that prevent the mixing of two or more drugs in the same solution. Pharmacodynamic interactions are those in which one compound influences the effect of another at receptors or effector organs, or on subsequent molecular processes. Pharmacokinetic interactions occur when food modifies the normal pharmacokinetics of the drug, resulting in changes in its concentration in the body and, consequently, at its sites of action, which may affect therapeutic activity, often increasing it. These effects may be related to alterations in intestinal motility and gastric emptying. Changes in gastrointestinal motility can influence both the rate of absorption and the total amount of drug absorbed, which may ultimately be complete. Factors that affect drug response include both pharmacokinetic and pharmacodynamic mechanisms. Pharmacokinetic interactions may occur at any stage of drug absorption, distribution, biotransformation, or excretion, leading to an increase or decrease in the concentration at the site of action. Pharmacodynamic interactions are due to changes in the response of the effector organ, giving rise to phenomena such as synergy, antagonism, or potentiation. Such interactions may occur at the receptor level, manifesting as antagonism, hypersensitization, or desensitization.
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Evaluación de las prescripciones médicas e interacciones medicamentosas en recetas relacionadas a COVID-19 atendidas en dos establecimientos de boticas Mifarma de los distritos de Comas y Los Olivos, Junio a Setiembre del 2020
(Universidad Privada Norbert Wiener, 2022-05-26) Mosquera Condor, Astrid Carolina; Aguilar Espinoza, Katherin Yajhaira; Justil Guerrero, Hugo Jesús
The objective of this research was to evaluate good prescribing practices (GPP) and identify drug interactions in prescriptions related to COVID-19. The methodology was deductive and quantitative, with a basic-exploratory research type and a non-experimental design. The study included 542 medical prescriptions related to COVID-19. Results: It was found that 7.01% of the prescriptions complied with GPP. The compliance for medication data was highest at 80.81%, followed by prescriber data at 34.31%, and patient data at 7.01%. A total of 54 drug interactions were identified. The most common interactions were: enoxaparin-dexamethasone (62), enoxaparin-ceftriaxone (59), azithromycin-hydroxychloroquine (57), aspirin-dexamethasone (29), enoxaparin-paracetamol (28), aspirin-levofloxacin (26), warfarin-dexamethasone (24), and warfarin-azithromycin and warfarin-ivermectin (23). Of all interactions, 60.5% were pharmacodynamic and 39.5% were pharmacokinetic. By onset, 5 were rapid, 24 were slow, and 25 were unknown. By severity, 8 were major, 33 were moderate, and 13 were minor. Conclusion: A low percentage of compliance with GPP was found. The lack of an established treatment guide for COVID-19 resulted in many of the medications used to mitigate patients' signs and symptoms causing a greater number of drug interactions.
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Evaluación y análisis de las interacciones medicamentosas en prescripciones médicas atendidas a pacientes ambulatorios período enero–julio 2021: revisión sistemática
(Universidad Privada Norbert Wiener, 2021-08-04) Cusipuma Lozano, Meylin Liset; Yslache Neyra, Lizbeth Thalia; Torres Veliz, Ernesto Raúl
A drug interaction occurs when the effect of a drug is altered by the administration of another, which can cause adverse reactions, putting the patient's health at risk. The objective of this research was to evaluate and analyze studies of drug interactions in medical prescriptions filled for outpatient patients. The study was basic, descriptive, with a retrospective and cross-sectional directionality. Data were collected from research published over the last 10 years on drug interactions in prescriptions for outpatient patients. The results were analyzed based on severity, type of interaction, type of documentary evidence, and frequency of interaction using a data collection form. Results: The predominant drug interactions by severity were moderate (62.4%). By type of documentary evidence, 'Good' predominated at 50.7%. By type of interaction, pharmacodynamic predominated at 53.6%, and by frequency, the most common was once (46%). Conclusion: It is important that a pharmacist be present in pharmaceutical establishments to detect possible drug interactions.
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Factores asociados a la prescripción e interacciones farmacológicas potenciales en pacientes de medicina interna del Hospital Hugo Pesce Pescetto, 2024
(Universidad Privada Norbert Wiener, 2025-05-02) Dextre Sanchez, Mariela Ines; Zevallos Flores, Orlando; Ñañez del Pino, Daniel
The objective of this research was to determine the factors associated with prescription and potential pharmacological interactions in internal medicine patients at the Hugo Pesce Pescetto Hospital, 2024. The method was deductive, non-experimental design, cross-sectional, descriptive level or scope, quantitative approach, and basic type. The sample consisted of 180 prescriptions, which were analyzed using the Drugs.com interaction checker, and the information obtained was recorded on an observation sheet. The results showed that, according to the number of medications in the prescriptions, 19.4% involved 2 to 3 medications per prescription, 52.8% involved 4 to 5 medications, 21.7% involved 6 to 7 medications, and 6.1% involved 8 to 10 medications. According to the sociodemographic factor, the most severe interactions were observed in 15.7% of women and 11.4% of men over 60 years old. According to frequency, 63.9% presented 1 to 2 pharmacological interactions, 23.3% had 2 to 5 interactions, 5.6% had 5 to 6 interactions, and 7.2% had 7 to 11 interactions. Regarding the type of interaction, 95.8% were pharmacodynamic and 4.2% pharmacokinetic. The most frequently involved medications were omeprazole (9.9%) and furosemide (6.8%). According to the severity of interactions, 74.9% were of moderate severity, 13.0% were of greater severity, 9.5% were of lesser severity, and 2.2% were contraindicated. It is concluded that there are factors associated with prescriptions that are responsible for drug interactions, with adults being the most affected.
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Identificación de errores de prescripción e interacciones medicamentosas en recetas médicas de pacientes hospitalizados del servicio de oncología de Clínica Internacional, San Borja, 2022
(Universidad Privada Norbert Wiener, 2023-02-03) Echabautiz Tomairo, Jessica Rosmery; Izquierdo Quispe, Mirla Ruth; Collantes Llacza, Adela Marlene
The objective of this study is to evaluate prescription errors and drug interactions in medical prescriptions for hospitalized patients in the oncology service of Clínica Internacional, San Borja, 2022. Methodology: The research followed a deductive method with a quantitative approach, basic, non-experimental, descriptive, and cross-sectional. The sampling was simple random probabilistic and included 317 prescriptions. An instrument with five sections was used: patient data with five indicators, medication data with seven indicators, prescriber data with four indicators, type of interaction with three indicators, and interaction category with three indicators. Results: Regarding prescription errors, patient allergies were omitted in 62.5% (198) of cases. In medication data, the pharmacological concentration was omitted in 25.2% (80) of cases. In prescriber data, the omission of the physician's seal had a minimal percentage of 2.8% (9). These percentages were higher compared to other indicators. Regarding drug interactions, 67.8% (924) were pharmacokinetic interactions, and 74.5% (1016) were category D interactions, both with high percentages compared to other indicators. Conclusion: The highest percentage of prescription errors was the omission of allergies, which could lead to severe and irreversible harm when medications are consumed. Additionally, the evaluated prescriptions showed a high percentage of drug interactions.
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Identificación de interacciones medicamentosas potenciales en recetas médicas atendidas en la farmacia ambulatoria del Hospital Carlos Lanfranco La Hoz, periodo setiembre–noviembre 2018
(Universidad Privada Norbert Wiener, 2019-03-06) Lovera Tataje, Maria Nicolasa; Herencia Torres, Victor Reynaldo
The objective of this study was to identify potential drug interactions in medical prescriptions filled by the psychiatry service at the outpatient pharmacy of the Carlos Lanfranco La Hoz Hospital from September to November 2018. A retrospective, descriptive, and cross-sectional study was conducted, in which information was collected from medical prescriptions. The study population consisted of 450 medical prescriptions filled by the psychiatry service after applying inclusion and exclusion criteria. The study found that out of the 450 validated prescriptions, 226 had potential drug interactions, for a total of 248 interactions. By gender, 136 (60.2%) were for female patients and 90 (39.8%) for male patients. The prescriptions with the most potential drug interactions were sertraline-clonazepam (50 cases, 20.16%), risperidone-fluoxetine (25 cases, 10.8%), and risperidone-clonazepam (16 cases, 6.5%). According to the mechanism of action, 96 (38.7%) interactions were pharmacokinetic, and 152 (61.3%) were pharmacodynamic. In terms of severity, the interactions were moderate (208 cases, 83.9%), major (40 cases, 16.1%), and minor (0 cases, 0%). Based on documentation type, 16 (6.5%) were excellent, 210 (84.7%) were good, and 22 were fair or poor. This study highlights the importance of identifying drug interactions to prevent health problems related to medication use and to seek the patient's well-being and improvement.
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Interacciones medicamentosas en pacientes atendidos en el servicio de medicina interna del Hospital Daniel Alcides Carrion. Callao 2022
(Universidad Privada Norbert Wiener, 2022-09-23) Santamaria Olivos, Esmilda Ysolina; Caldas Herrera, Emma
The method of this study was observational, cross-sectional, and non-experimental. Information was collected through medical prescriptions. The study population consisted of 500 medical prescriptions, with a sample of 220 prescriptions. The instrument used was a data collection sheet, which included four dimensions: Type of Interactions, Pharmacotherapeutic Group, Severity Grade, and Number of Interactions. The Micromedex database was utilized. The results showed that in terms of medication interactions, the most influential in the evaluated prescriptions were Pharmacodynamic interactions, accounting for a total of 150 (68%). Regarding the Pharmacotherapeutic Group, antibiotics were the most commonly observed group, with 47 (21.0%). For the Severity Grade, most cases were moderate, with 141 (64%). Additionally, for the Number of Interactions, the most influential was prescriptions with 1 interaction, at 79 (36.0%). It was concluded that 76% of the 220 analyzed medical prescriptions presented medication interactions.
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Interacciones medicamentosas en pacientes pediátricos atendidos en el Policlínico Policial Ica en el año 2022
(Universidad Privada Norbert Wiener, 2022-12-12) Huaripaucar Gutierrez, Rocio Edith; Caldas Herrera, Emma
Objective: To evaluate drug interactions in pediatric patients treated at the Policlínico Policial Ica in 2022. Methodology: The total sample consisted of all prescriptions for pediatric patients, totaling 117 prescriptions. The study was conducted using a deductive, quantitative, applied, and observational approach. Results: Regarding the presence of medication, 2.6% of participants showed some presence of drug interactions, while 97.4% did not register any medication presence. Regarding severity level, 0.9% of participants exhibited a moderate severity level, 1.7% exhibited a minor severity level, 2.6% of participants presented a type of interaction classified as pharmacodynamic, 1.7% showed an excellent level of evidence, and 0.9% showed good clinical evidence. Conclusion: It is concluded that, based on the consulted prescriptions, drug interactions were minimal concerning the study's sample and population.
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Interacciones medicamentosas potenciales asociados a polifarmacia en prescripciones de pacientes de la Unidad de Cuidados Intensivos de la Clínica San Pablo, febrero–abril 2021
(Universidad Privada Norbert Wiener, 2021-10-04) Huayta Pillco, Fiorela; Torres Veliz, Ernesto Raúl
This research aimed to determine the relationship between polypharmacy and the presence of potential drug interactions by evaluating prescriptions for patients in the Intensive Care Unit of a local clinic. A descriptive, prospective, and correlational study was conducted, using a data collection form as the instrument. The Micromedex database was used to evaluate pharmacotherapy, and the Pearson's Chi-squared test and Spearman's Rho Correlation Coefficient were used for hypothesis testing. A total of 283 prescriptions were evaluated, with 51.9% containing 6 to 10 medications. The most common comorbidity was arterial hypertension (46.3%), and 57.6% of the patients were aged between 50 and 69. Regarding interaction frequency, 46.6% of prescriptions had 1 to 5 interactions, followed by 35.4% with 6 to 10 interactions. The most frequent therapeutic group involved was opioid analgesics (22.6%). The most predominant type of interaction was pharmacodynamic (66%), and 61.8% had a major severity level. Finally, it was determined that polypharmacy is significantly related to the presence of potential drug interactions.
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Interacciones medicamentosas potenciales en la Unidad Hospitalaria de Medicina Interna del Hospital Militar Central Jesús María – Lima Metropolitana, periodo enero–agosto del 2021
(Universidad Privada Norbert Wiener, 2023-03-17) Guzman Villanueva, Johann Ronny; Castillo Soto, Pedro Félix
Drug interactions occur when the object drug is modified by another drug called the precipitant, leading to two types of interactions: pharmacokinetic and pharmacodynamic. This demonstrates that evaluating and/or determining the onset of a drug interaction becomes more complex for the immediate intervention of healthcare professionals. The present study aimed to identify potential drug interactions in the Internal Medicine hospital unit of the Central Military Hospital Jesús María-Lima Metropolitana, during the period January - August 2021. The method was analytical, descriptive, and non-experimental, and the document analysis technique was used. For the evaluation of interactions, the Micromedex database was employed. Results: Regarding age and gender, 76.6% of the cases involved males, and the age group with the highest prevalence of interactions was 30-59 years, accounting for 87.7%. The most frequent interaction was dexamethasone-diclofenac at 8.5%. The type of interaction was pharmacodynamic in 73.9% of cases. The therapeutic group with the highest prevalence was group A, with 20.2%, and the severity level with the greatest predominance was "important," at 73.9%.
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Interacciones medicamentosas potenciales en las prescripciones médicas de la unidad de cuidados intensivos de la Clínica Internacional sede Lima de enero a marzo de 2018
(Universidad Privada Norbert Wiener, 2018-12-07) Contreras Agustin, Kely Luz; Torres Veliz, Ernesto Raúl
The objective of the present study was to identify the potential drug interactions in medical prescriptions of the Intensive Care Unit of the Clínica Internacional. The study was retrospective, descriptive, and cross-sectional, conducted between January and March 2018, considering the selection criteria. Uptodate®-Lexicomp® and Pearson’s correlation test were used. A total of 444 medical prescriptions were analyzed, of which 355 presented at least one interaction, yielding 1646 interactions. The most frequent were fentanyl + midazolam with 59 (3.6%). The most frequent pharmacological group was opioid analgesics with 371 (11.3%). The most frequent medications were fentanyl 236 (7.2%), phenytoin 208 (6.4%), risperidone 169 (5.2%), furosemide 162 (5%), and metoclopramide 155 (4.7%). According to the type of interaction, pharmacodynamic were 1135 (69%), pharmacokinetic 462 (28%), and of unknown origin 49 (3%). According to their risk rating category, 179 (11%), 1042 (63%), 296 (18%), and 129 (8%) corresponded to categories B, C, D, and X, respectively. According to the degree of severity, 436 (26.5%) were major, 1068 (64.9%) moderate, and 142 (8.6%) minor. The relationship between the number of prescribed medications and the number of potential drug interactions was evaluated, determining a significant high positive correlation coefficient.
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Interacciones medicamentosas potenciales en las prescripciones médicas de los fármacos psicotrópicos atendidas en la Farmacia Universal sede Lima, periodo enero–julio 2016
(Universidad Privada Norbert Wiener, 2018-04-27) Palomino Torres, Edwin Manuel; Rojas Chuquilín, Ever Alonso; Rodríguez Arizabal, Julio Cesar
The study was carried out with the purpose of identifying potential drug interactions in medical prescriptions of psychotropic drugs dispensed at Farmacia Universal, Lima branch, during the period January–July 2016. A descriptive, retrospective, cross-sectional study was conducted. The study population consisted of 444 medical prescriptions after applying the inclusion and exclusion criteria. It was observed that, of the 444 psychotropic drug prescriptions, 162 presented drug interactions, with a total of 187 drug interactions identified. The prescriptions with the highest number of potential drug interactions were those containing alprazolam, with 33 interactions, followed by clonazepam, with 20 interactions, and sertraline, with 19 interactions. According to their mechanism of production, 70 interactions (37.4%) were pharmacokinetic and 117 (62.6%) were pharmacodynamic. According to their onset, 142 (75.82%) were of unspecified onset, 37 (19.9%) of slow onset, and 8 (4.3%) of rapid onset. According to their severity, 128 (68.4%) were moderate interactions, 34 (18.2%) unspecified, 13 (7.0%) minor, and 12 (6.4%) major. Furthermore, 143 prescriptions (88.3%) presented one drug interaction, while 19 prescriptions (11.7%) presented two or more interactions.
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Interacciones medicamentosas potenciales en las recetas de la Unidad de Cuidados Intensivos de una clínica privada, Lima – 2021
(Universidad Privada Norbert Wiener, 2022-07-09) Aguirre Montalvo, Deysi Maribel; Moreno Yaranga, Kathia Marlene; Justil Guerrero, Hugo Jesús
The objective of this research was to identify potential drug interactions in prescriptions from the Intensive Care Unit of a Private Clinic in Lima, in 2021. Methodology: This was an applied study using a deductive method and a descriptive level. A sample of 211 prescriptions was obtained and analyzed using the Drugs.com interaction checker. The information was recorded in a data collection form that included five dimensions: interactions per prescription, types of interaction, most frequent pharmacotherapeutic groups, most prevalent medications, and degree of severity. Data was processed using Excel version 2016. Results: A total of 830 potential drug interactions were identified, with the most frequent being dimenhydrinate-tramadol (27 cases, 3.3%). Regarding the number of interactions, 60.7% of prescriptions had 1 to 3 interactions. The most common type of interaction was pharmacodynamic (63.6%). The most frequent pharmacotherapeutic groups were antihypertensives (11.7%) and anti-ulcer agents (7.7%), and the most prevalent medication was omeprazole (6.2%). In terms of severity, moderate interactions accounted for 76.4%. Conclusion: A total of 830 potential drug interactions with clinical importance were identified in the prescriptions from the Intensive Care Unit of a Private Clinic in Lima in 2021.
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Interacciones medicamentosas potenciales en pacientes con cáncer de mama del servicio de medicina paliativa del Instituto Nacional de Enfermedades Neoplásicas
(Universidad Privada Norbert Wiener, 2017) Barrios Jara, Elizabeth Yessica; Chávez Fernández, Ana María
The present study was carried out with the purpose of determining the potential drug interactions in prescriptions dispensed to breast cancer patients from the Palliative Medicine Service of the National Institute of Neoplastic Diseases (INEN) during the period November 2015 – October 2016. A non-experimental, descriptive, retrospective, cross-sectional study was conducted, analyzing 316 prescriptions that met the inclusion and exclusion criteria. In 287 (90.82%), at least one potential drug interaction (PDI) was identified. When performing Pearson’s correlation between the number of prescribed drugs and the number of PDIs, the relationship was found to be highly significant (sig = 0.00 < 0.05), and the correlation coefficient (Rho = 0.481) indicated a moderate positive correlation. A total of 889 PDIs were identified, the most frequent being tramadol + amitriptyline (13%), metoclopramide + amitriptyline (10%), and morphine + amitriptyline (9%). According to their mechanism of production, 218 (24.5%) were pharmacokinetic in origin, 489 (55.0%) pharmacodynamic, and 182 (20.5%) unknown. According to their severity level, 91 (10.2%) were contraindicated, 439 (49.4%) major, 348 (39.1%) moderate, and 11 (1.2%) minor. It is concluded that the presence of PDIs is evident and that the intervention of the Pharmaceutical Chemist is necessary to prevent possible adverse events.
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Interacciones medicamentosas potenciales en pacientes con diagnóstico en diabetes mellitus tipo 2 del servicio de medicina del Hospital de Emergencias Villa el Salvador. Lima 2021
(Universidad Privada Norbert Wiener, 2022-03-16) Loaiza Munares, Carolina; Caldas Herrera, Emma
The objective of this research was to analyze Potential Drug-Drug Interactions (PDDIs) in patients diagnosed with Type 2 Diabetes Mellitus (T2DM) in the medicine service of the HEVES Hospital in Lima in 2021. The methodology used was deductive, with a quantitative approach, an applied type, a descriptive level, and a non-experimental, cross-sectional observational design. The sample consisted of 205 clinical records. The observation technique, with its duly validated instrument (data collection form), was used. Results: A total of 312 PDDIs were identified in 123 clinical records from the total sample. In the severity dimension, the important type was most prevalent at 49.7%. In the interaction mechanism dimension, the pharmacodynamic type was highest at 64.4%. In the clinical evidence dimension, the 'Fair' type was most prevalent at 85.6%. By age and sex, the highest percentage was found in males (56%), in the 18 to 59 age group (57%). The most frequently prescribed associations were Insulin - Metformin (20%), followed by Insulin – Losartan (7%). Conclusion: A high percentage of PDDIs were identified in patients diagnosed with T2DM.