Examinando por Materia "Drug Resistant Epilepsy"

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Acceso abierto
Critical review: effect of the ketogenic diet on the reduction of seizures in children with refractory epilepsy
(Universidad Privada Norbert Wiener, 2023-06-22) Ponce Mora, Giannina; Bohórquez Medina, Sofia Lorena
Nutritional intervention plays a fundamental role in improving the quality of life of children with refractory epilepsy. In this critical review, titled “Effect of the Ketogenic Diet on Seizure Reduction in Children with Drug-Resistant Epilepsy,” the aim was to assess the effectiveness and tolerance of two dietary approaches: the Modified Atkins Diet (MAD) and the traditional Ketogenic Diet (KD). The main clinical question was: Will the ketogenic diet, whether in its classic or modified version, have an effect on seizure reduction in children of both sexes with refractory epilepsy? An Evidence-Based Nutrition (EBN) criterion was employed. 25 scientific articles were identified, and 12 relevant studies were selected for analysis, evaluated using the CASPE critical reading tool. Finally, a randomized clinical trial titled “Modified Atkins Diet versus Ketogenic Diet in Children with Drug-Resistant Epilepsy: A Meta-Analysis” was chosen, considered relevant due to its level of evidence I and strong recommendation grade, according to the author's experience. This study provided promising results by demonstrating that both ketogenic nutritional therapy, in its classic (KD) and modified (MAD) versions, significantly reduced seizures and/or achieved seizure freedom. The adverse effects associated with both therapies can be managed through careful monitoring and follow-up. Both treatments showed acceptable tolerance and can be considered as options within the framework of nutritional intervention for these patients.
Acceso abierto
Effectiveness of the administration of cannabis oil in pediatric patients with refractory epilepsy
(Universidad Privada Norbert Wiener, 2019-10-20) Quispe Gutierrez, Myriam Pamela; Gomez Espiritu, Cecilia del Pilar; Cárdenas de Fernández, María Hilda
Objective: Systematize the evidence on the effectiveness of the administration of cannabis derivatives in reducing seizures in the treatment of patients with refractory epilepsy. Material and Methods: Systematic review meta-analysis, using the GRADE evaluation system to assess the level of evidence, found in the following databases: Pubmed, Pediatrics Official Journal of the AAPS, Scielo, Wiley Online Library. A total of 25 articles were found, but only 10 articles were selected and systematically reviewed. 80% (n = 08/10) of them are systematic reviews, and 20% (n = 02/10) are community-controlled trials. According to the results of the systematic review conducted in this study, the articles come from the countries of Argentina (10%) (n = 01/10), followed by Australia (10%) (n = 1/10), Brazil (10%) (n = 01/10), Canada (20%) (n = 02/10), the USA (30%) (n = 03/10), and Italy (20%) (n = 02/10). Results: Of all the articles found in the systematic review, the use of cannabinoids showed significant effectiveness in the treatment of patients with refractory epilepsy, reducing the number of seizures and improving their quality of life when used as an adjunctive treatment. Conclusion: 100% of the articles used show the effectiveness, in varying degrees, of using cannabinoids for the treatment of drug-resistant epilepsy. However, many of these indicate that further knowledge is needed to accept these results and make them an approved treatment by health authorities worldwide.