Examinando por Materia "Drug Synergism"

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Interacciones medicamentosas potenciales en las prescripciones médicas de los fármacos psicotrópicos atendidas en la Farmacia Universal sede Lima, periodo enero–julio 2016
(Universidad Privada Norbert Wiener, 2018-04-27) Palomino Torres, Edwin Manuel; Rojas Chuquilín, Ever Alonso; Rodríguez Arizabal, Julio Cesar
The study was carried out with the purpose of identifying potential drug interactions in medical prescriptions of psychotropic drugs dispensed at Farmacia Universal, Lima branch, during the period January–July 2016. A descriptive, retrospective, cross-sectional study was conducted. The study population consisted of 444 medical prescriptions after applying the inclusion and exclusion criteria. It was observed that, of the 444 psychotropic drug prescriptions, 162 presented drug interactions, with a total of 187 drug interactions identified. The prescriptions with the highest number of potential drug interactions were those containing alprazolam, with 33 interactions, followed by clonazepam, with 20 interactions, and sertraline, with 19 interactions. According to their mechanism of production, 70 interactions (37.4%) were pharmacokinetic and 117 (62.6%) were pharmacodynamic. According to their onset, 142 (75.82%) were of unspecified onset, 37 (19.9%) of slow onset, and 8 (4.3%) of rapid onset. According to their severity, 128 (68.4%) were moderate interactions, 34 (18.2%) unspecified, 13 (7.0%) minor, and 12 (6.4%) major. Furthermore, 143 prescriptions (88.3%) presented one drug interaction, while 19 prescriptions (11.7%) presented two or more interactions.