Examinando por Materia "Edema"

Mostrando 1 - 3 de 3

Acceso abierto
Aspiración de secreciones subglóticas como alternativa eficaz para la prevención de neumonía en pacientes con ventilación mecánica
(Universidad Privada Norbert Wiener, 2020-02-29) Costa Pisfil, Erika Amavila; Elías Garcia, Karen Pamela; Avila Vargas Machuca, Jeannette Giselle
Objetivos Sistematizar las evidencias sobre la eficacia de las aspiraciones subglóticas para la reducción de Neumonía en pacientes con ventilación mecánica. Materiales y Métodos: Revisión Sistemática observacional y retrospectiva, la búsqueda se ha basado exclusivamente en los artículos con texto completo, y los estudios elegidos fueron sometidos a una lectura crítica, basándose en la evaluación de GRADE para identificar su grado de evidencia. En la selección se eligieron 10 artículos, de los cuales el 20% (2/10) corresponden a Estados Unidos, 20% (2/10) Australia, 10% (1/10) a la India, 20% (2/10) Canadá, 10% (1/10) China, 10% (1/10) Francia y 10% (1/10) Bélgica. De estos son 2 revisiones sistemáticas, 4 meta-análisis, 3 ensayos clínicos y 1 estudio control, todos de alta calidad. Resultados: De los 10 artículos revisados, el 100% (10/10) demostró que la aspiración de secreciones subglóticas reduce la incidencia de neumonía y los problemas de edema comparado con las aspiraciones traqueales. Conclusiones: Se evidenció que las aspiraciones de secreciones subglóticas son eficaces para la reducción del riesgo de neumonías asociadas a ventilación mecánica.
Acceso abierto
Efecto antiinflamatorio del extracto hidroalcohólico de las hojas de Luma Chequen (Molina) A. Gray “Arrayán” mediante el método de edema subplantar en ratas
(Universidad Privada Norbert Wiener, 2019-12-02) Linares Martínez, Dámaris Rosana; Chávez Flores, Juana Elvira
The objective of this research was to confirm the anti-inflammatory effect of the hydroalcoholic extract from the leaves of Luma chequen (Molina) A. Gray, 'arrayán,' using the subplantar edema method in rats. Materials and methods: Solubility and qualitative analyses were performed. To determine the anti-inflammatory effect, a modified subplantar edema method with a 1% albumin solution was used. 48 albino rats (Holtzman strain), with an average weight of 200-250g, were acclimated for 7 days and randomly distributed into six groups of eight. Afterward, 0.1 mL of a 1% albumin solution was applied to the subplantar area. The hydroalcoholic extract was used at doses of 200, 400, and 600 mg/kg of body weight, and dexamethasone (4 mg/kg) and diclofenac (50 mg/kg) were used as standard drugs. Results: The hydroalcoholic extract showed solubility in distilled water, ethanol, and methanol. The qualitative analysis confirmed the presence of flavonoids, phenols, tannins, alkaloids, coumarins, and steroids and/or triterpenoids. In the anti-inflammatory effect evaluation, the extract at a dose of 200 mg/kg showed an inflammatory inhibition of 82.3% at the sixth hour, which was greater than diclofenac's 77.1% and comparable to dexamethasone's 90.1%. Conclusions: The anti-inflammatory effect of the hydroalcoholic extract from the leaves of Luma chequen (Molina) A. Gray, 'arrayán,' was confirmed. At a dose of 200 mg/kg, its effect was greater than diclofenac's and comparable to dexamethasone.
Acceso abierto
Efecto antiinflamatorio y analgésico del extracto hidroalcohólico de las hojas de Rumex cuneifolius Campd. “Romaza” mediante el método de edema subplantar y contorsiones abdominales en ratones albinos (Mus musculus)
(Universidad Privada Norbert Wiener, 2019-03-08) Sánchez Porras, Katheryne; Zavala Villanueva, Hellen Katerine; Ñañez del Pino, Daniel
In this study, the anti-inflammatory and analgesic effects of the hydroalcoholic extract from the leaves of Rumex cuneifolius Campd., known as "Romaza," were evaluated using the subplantar edema and abdominal writhing methods in albino mice (Mus musculus). Materials and Methods: A hydroalcoholic extract was obtained by maceration with 70% ethanol. The anti-inflammatory effect was assessed using the 1% albumin-induced subplantar edema method. The mice were divided into a Control Group, a diclofenac group (50 mg/kg), a dexamethasone group (4 mg/kg), and a hydroalcoholic extract group at doses of 50, 100, and 150 mg/kg. The analgesic effect was evaluated using the 0.8% glacial acetic acid-induced abdominal writhing model. The mice were divided into a Control Group, a paracetamol group (300 mg/kg), a tramadol group (40 mg/kg), and a hydroalcoholic extract group at doses of 50, 100, and 200 mg/kg. Results and Conclusion: The extract showed solubility in both ethanol and methanol. The qualitative phytochemical analysis revealed the presence of primary metabolites (carbohydrates and amino acids) and secondary metabolites (phenolic compounds, flavonoids, steroids and/or triterpenes, sesquiterpene lactones, quinones, and alkaloids). The study determined that the ideal dose for the anti-inflammatory effect was 100 mg/kg, with an effectiveness of 94%. The analgesic effect was confirmed at a dose of 100 mg/kg, showing a 75% effectiveness. In conclusion, the hydroalcoholic extract from the leaves of Rumex cuneifolius Campd. "Romaza" demonstrates both anti-inflammatory and analgesic effects.