Examinando por Materia "Fatty Acids, Omega-3"

Mostrando 1 - 20 de 22

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Critic review: correlation of dietary or supplemental omega-3 consumption and excess malnutrition Traducido por
(Universidad Privada Norbert Wiener, 2020-01-03) Rebaza Vílchez, Julio César; Bohórquez Medina, Andrea Lisbet
Obesity, according to the WHO, is considered a global pandemic and its rate has tripled in the last 20 years. Various studies have investigated the role of omega 3 in obesity, with scattered results that do not allow their recommendation. This study is titled: critical review: Correlation of dietary or supplemental omega-3 consumption and malnutrition due to excess; The objective was to correlate the consumption of omega 3 with malnutrition due to excess and to make a critical comment on the selected article. The clinical question was: Is the consumption of dietary or supplemental Omega 3 beneficial in the treatment of men and women over 18 years of age with overweight or obesity? The methodology used was Evidence-Based Nutrition (NuBE), information was searched in PUBMED, SCOPUS, REDALYC and HINARI, finding 37 articles, of which 16 were evaluated through the CASPE tool, selecting the systematic review: Effects of omega-3 supplementation on body weight and body fat mass: A systematic review, with AI level of evidence and Strong recommendation grade. It is concluded that there is no consensus that omega-3 is beneficial in losing weight or body fat mass in humans.
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Critical review: effect of omega-3 fatty acid supplementation in adult patients with hypertriglyceridemia
(Universidad Privada Norbert Wiener, 2022-08-22) Espinoza Lázaro, Jhonny Alfredo; Palma Gutiérrez, Edgardo Jhoffire
An information search was carried out in the Medline and Cochrane databases, finding 32 articles, 11 being selected, which have been evaluated by the CASPE critical reading tool, finally the selected article allowed us to conclude that supplementation with 2 and 4 g/ omega-3 day for 8 weeks could be useful in reducing hypertriglyceridemia in adult patients.
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Critical review: effect of omega-3 fatty acid supplementation on nutritional indicators and clinical outcomes in patients with colorectal cancer.
(Universidad Privada Norbert Wiener, 2021-07-22) Windmueller Cortés, Andrea Marina; Palma Gutiérrez, Edgardo Jhoffire
The Evidence-Based Nutrition (NuBE) methodology was used to develop this work. The information search was carried out in Medline and Cochrane, finding 62 articles, 6 being selected that have been evaluated by the CASPE critical reading tool. The critical commentary allowed us to conclude that supplementation with 3 g of omega-3 fatty acids of marine origin did not improve nutritional indicators and clinical outcomes in this group of adult patients with colorectal cancer.
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Critical review: Effect of omega-3 supplementation on clinical outcomes in critically ill adult patients
(Universidad Privada Norbert Wiener, 2024-04-17) Peña Zúñiga, Pilar; Ponce Castillo, Diana Antonia
Early nutritional intervention in critically ill patients has shown several benefits, including reduced complications and improved clinical outcomes in patients at nutritional risk. This secondary research, titled "Critical Review: Effect of Omega-3 Supplementation on Clinical Outcomes in Adult Critically Ill Patients," aimed to investigate the benefits of omega-3 supplementation in critically ill adults. The clinical question was: What is the effect of omega-3 supplementation on clinical outcomes (mortality and hospital stay) in critically ill adult patients? Evidence-based nutrition (NuBE) methodology was used. The search for information was conducted in PUBMED, BIBLIOTECA VIRTUAL EN SALUD, COCHRANE LIBRARY, SEVIER, DYNAMED, SPRINGER, WILEY ONLINE LIBRARY, KARGER, with 43 articles found, and 10 were selected for critical reading evaluation using the CASPE tool. The randomized clinical trial titled "The Effect of Omega-3 Supplementation on Clinical and Biochemical Parameters in Critically Ill COVID-19 Patients: A Randomized Controlled Trial" was selected. The critical commentary concluded that omega-3 supplementation could have beneficial effects on the immune system of patients with viral infections and improve several parameters of respiratory and renal function in critically ill COVID-19 patients. However, further clinical studies are needed to validate these findings.
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Critical review: effect of omega-3 supplementation on the reduction of symptoms of arthralgia in adult women with breast cancer
(Universidad Privada Norbert Wiener, 2024-06-20) Menacho Flores, Rosario Nora; Bohórquez Medina, Andrea Lisbet
Omega-3 fatty acids play a role in nutritional treatment due to their therapeutic effect on cancer, mainly because of their anti-inflammatory properties, and should be incorporated into the diet. Patients undergoing hormone therapy with aromatase inhibitors for hormone-positive breast cancer are more likely to experience arthralgia, leading to early treatment interruption. The objective was to determine the effect of Omega-3 supplementation on improving arthralgia symptoms in these patients. Information was searched on PUBMED, COCHRANE, and SCIENCE DIRECT, finding 32 articles, 10 of which were evaluated using the CASPE critical reading tool. Finally, a systematic review and network meta-analysis were selected, with a level of evidence AI and a strong recommendation grade. The critical discussion concluded that taking Omega-3 polyunsaturated fatty acid (PUFA) supplements, on average 3.3g/day with a 40:20 EPA/DHA ratio for 24 weeks, reduced the worst pain scale, though no significant difference was found compared to placebo or other treatments. The risk of side effects was low in breast cancer patients with arthralgia.
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Critical review: effect of supplementation with Omega 3 fatty acids on clinical and nutritional parameters in patients diagnosed with pancreatic cancer
(Universidad Privada Norbert Wiener, 2022-08-25) Huarcaya Zavaleta, Alexsandra Pilar; Espinoza Rado, Erika Paola
The effect of supplementation with omega-3 polyunsaturated fatty acids in patients diagnosed with pancreatic cancer disease has already been demonstrated to have an antitumor impact in vivo and in vitro on the pancreatic cancer cell chain. The present secondary research titled as a critical review: EFFECT OF SUPPLEMENTATION WITH OMEGA 3 FATTY ACIDS ON CLINICAL AND NUTRITIONAL PARAMETERS IN PATIENTS DIAGNOSED WITH PANCREAS CANCER aimed to provide a professional critical commentary on the topic of the effect of oral supplementation enriched with omega 3 EPA and to help with the clinical and nutritional parameters of patients diagnosed with pancreatic cancer.
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Critical review: Effectiveness of omega-3 fatty acid supplementation in reducing blood pressure in adults with hypertension
(Universidad Privada Norbert Wiener, 2023-12-05) Serrano Rojas, Marlene Reyna; León Cáceres, Johanna del Carmen
The nutritional intervention is to publicize the “Effectiveness of supplementation with omega 3 fatty acids in reducing blood pressure in adults with high blood pressure”, The present secondary research titled as a critical review: “Effectiveness of supplementation with omega 3 fatty acids 3 in reducing blood pressure in adults with high blood pressure”, aimed to identify whether supplementation with omega 3 fatty acids reduces blood pressure in adults with high blood pressure. The clinical question was: Does omega-3 fatty acid supplementation reduce blood pressure in adults with high blood pressure? The Evidence-Based Nutrition (NuBE) methodology was used. The information search was carried out in PUBMED, finding 30 articles, 10 were selected that have been evaluated by the CASPE critical reading tool, finally selecting the Randomized Clinical Trial entitled "Reduction of the effects of n-3 fatty acid supplements on blood pressure by reducing plasma Angiotensin II of hypertensive patients from Inner Mongolia: A double-blind randomized controlled trial” which has a level of evidence I and Grade of Recommendation I, according to the researcher's expertise. The critical comment allowed us to conclude that blood pressure can be reduced by consuming omega 3 supplements.
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Critical Review: Effects of Omega-3 on the Human Microbiota of At-Risk Adults metabolic
(Universidad Privada Norbert Wiener, 2022-02-15) Talledo Olaya, Silvia María; Dávila Córdova, Jennifer Estefania
The clinical question was: - What is the effect of omega 3 fatty acids on the modulation of the microbiota in adults over 18 years of age with any metabolic disease? The Evidence-Based Nutrition (NuBE) methodology was used. The information search was carried out in PUBMED, , SCIELO, HINDAWI, , finding 15 articles, 10 being selected that have been evaluated by the CASPE critical reading tool, finally selecting the Randomized Clinical Trial titled “Diets naturally rich in polyphenols and/or or long-chain n-3 polyunsaturated fatty acids differently affect microbiota composition in high-cardiometabolic-risk individuals”, which has a level of evidence I and Grade of Recommendation I, according to the expertise of the researcher. The critical commentary allowed us to conclude that diets naturally rich in polyphenols or long-chain n-3 polyunsaturated fatty acids can modulate the intestinal microbiota and these changes are related to an improvement in the cardiometabolic risk profile.
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Critical Review: effects of oral omega-3 supplementation on inflammatory markers in adult patients with chronic kidney disease
(Universidad Privada Norbert Wiener, 2022-05-18) Dávila Chávez, Milagros Andrea; Ponce Castillo, Diana Antonia
Nutrition is crucial in the treatment of patients when performed timely and adequately. The objective of this secondary research, critical review: Impact of oral supplementation with omega-3 on inflammatory markers in adult patients with chronic kidney disease, was to determine its effect on inflammatory biomarkers. What is the impact of oral supplementation with omega-3 fatty acids on inflammatory markers in patients with chronic kidney disease? was the clinical question. The methodology used was Evidence-Based Nutrition (NuBE). Data collection was conducted on PubMed and the virtual health library, resulting in 30 articles, of which 10 underwent critical reading using the CASPE instrument. The clinical trial titled 'Oral supplementation with omega-3 fatty acids and inflammation markers in patients with chronic kidney disease on hemodialysis' was selected, and due to the investigator's expertise, it had a level of evidence AI and a strong degree of recommendation. The critical review concluded that omega-3 supplementation has a significant impact on reducing inflammatory markers like IL-6, TNF-alpha, and CRP.
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Critical review: omega 3 supplementation on the lipid profile in patients with chronic kidney disease with hemodialysis treatment
(Universidad Privada Norbert Wiener, 2022-06-07) Recoba Obregón, Paulo Eder; Bohórquez Medina, Andrea Lisbet
Omega-3 supplementation is an adequate nutritional intervention to prevent cardiovascular risks in patients with chronic kidney disease (CKD) undergoing dialysis treatment. This secondary research study titled "Omega-3 supplementation on lipid profile in patients with chronic kidney disease on hemodialysis treatment" aimed to identify the effect of omega-3 supplementation on the lipid profile in CKD patients undergoing hemodialysis. The clinical question was: Will omega-3 supplementation (capsules) improve the lipid profile (expressed in total cholesterol, LDL, HDL, and triglycerides) in CKD patients on hemodialysis? The methodology used was Evidence-Based Nutrition (NuBE). The databases used for the literature search were PUBMED, MEDLINE, SCIELO, SCOPUS, DIALNET, reporting 200 scientific studies, selecting 11 articles to be evaluated using the CASPE critical reading tool, with the systematic review and meta-analysis titled "Effect of omega-3 supplementation on oxidative stress and cardiometabolic parameters in chronic kidney disease patients: systematic review and meta-analysis" being selected. This article had an evidence level of BI and a strong recommendation grade, according to the researcher’s expertise. The critical commentary concludes that omega-3 supplementation is recommended for lowering total cholesterol and triglycerides in patients with CKD undergoing hemodialysis.
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Effect of omega 3 supplementation in the treatment of patients with non-alcoholic hepatic steatosis
(Universidad Privada Norbert Wiener, 2022-05-16) Cutimbo Huanca, Mayda Marianela; Bohórquez Medina, Andrea Lisbet
Non-alcoholic fatty liver disease (NAFLD), defined as liver damage resulting from the accumulation of excess fat within hepatocytes, which leads to a chronic inflammatory process. The aim of the study was to identify the effect of omega-3 supplementation in patients with NASH; to do so, the research question was formulated: What is the effect of omega-3 supplementation in patients with NASH? Subsequently, the bibliographic search process was carried out in the PUBMED and EMBASE databases, selecting a total of 17 clinical studies, evaluated according to the CASPE tool, for the development of critical reading. Finally, the double-blind randomized clinical trial entitled "Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial" was analyzed, rated with a level of evidence A and a grade of recommendation Strong. The critical analysis concludes that in patients with NASH, supplementation with omega-3 polyunsaturated fatty acids, such as linseed and fish oils, has a significant impact on the plasma lipid profile. Furthermore, increased plasma levels of these PUFAs were associated with improved liver histology and morphology.
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Effect of omega-3 supplementation on stress reactivity of biomarkers of cellular aging in middle-aged adults
(Universidad Privada Norbert Wiener, 2022-05-18) Rodriguez Villanueva, Ruth Zurama; Inocente Camones, Miguel Angel
Aging is the gradual loss of the potential of our cells and organism. Cells are in constant renewal throughout our lives. When cells begin to fail in the renewal process, new cells stop replicating identically to the mother cell, undergoing mutation. The present secondary research, titled "Critical Review: Omega-3 Supplementation and Stress Reactivity of Cellular Aging Biomarkers in Middle-Aged Adults," aimed to analyze the impact of omega-3 supplementation on stress reactivity and telomerase. The clinical question was: What is the effect of omega-3 supplementation on cortisol stress reactivity and telomerase in middle-aged patients? The evidence-based nutrition (NuBE) methodology was used. The information search was conducted in the PubMed and Cochrane databases, finding 236 articles, of which 5 were selected. These were evaluated using the CASPE critical reading tool, with the final selection being the randomized clinical trial titled "Omega-3 supplementation and stress reactivity of cellular aging biomarkers: an ancillary substudy of a randomized, controlled trial in midlife adults," which has an evidence level of A I and a strong recommendation grade, according to the researcher’s expertise level. The critical comment concluded that nutritional intervention with omega-3 prevents cellular aging in middle-aged adults.
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Effectiveness of Omega-3 fatty acids for preventing cognitive decline in the elderly
(Universidad Privada Norbert Wiener, 2018-12-02) Chipana Mendoza, Yanet; Tello Huanca, Wilma; Rivera Lozada De Bonilla, Oriana
Materials and Methods: Systematic reviews are a form of research that collects and provides a summary on a specific topic, aimed at answering a research question. They must be conducted according to a pre-established design. This systematic review includes 10 articles selected through the databases Epistemonikos, PubMed, ResearchGate, and SciELO. The 10 selected articles are quantitative studies: 10% (N=1/10) are meta-analyses, 30% (N=3/10) are systematic reviews, 50% (N=5/10) are randomized clinical trials, and 10% (N=1/10) are cohort studies. Results: In this systematic review, based on the evidence found, 60% (N=6/10) indicate that omega-3 fatty acids are effective in preventing cognitive decline in older adults. Conclusion: Omega-3 fatty acids are effective in preventing cognitive decline in older adults.
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Effectiveness of the administration of Omega-3 fatty acids in reducing the adverse effects of chemotherapy in cancer patients
(Universidad Privada Norbert Wiener, 2019-08-25) Rodríguez Zambrano, Johanna Elizabeth; Pretell Aguilar, Rosa María
Objective: Systematize the evidence on the effectiveness of the administration of omega-3 fatty acids in reducing the adverse effects of chemotherapy in cancer patients. MATERIAL AND METHOD: The study is quantitative, with a systematic, observational and retrospective review design; of articles with full text, which identified their grade or quality of evidence according to the Grade System. Likewise, the population was made up of 10 most relevant scientific articles that were obtained from the following databases Pubmed, Medline, Embase, Cochrane Library, Dialnet, Scielo, and Lilacs. Of which 70% correspond to the methodological design of systematic review and 30% to randomized clinical trials, corresponding to the countries of the United States 20% (02/10), Holland 10% (01/10), Iran 10% (01 /10), Portugal 10% (01/10), Italy 10% (01/10), Colombia 10% (01/10), South Korea 10% (01/10), Mexico 10% (01/10), and Spain 10% (01/10). Results: Of the 10 articles reviewed, (10/10), 100% demonstrate effectiveness of the administration of omega-3 fatty acids in reducing the adverse effects of chemotherapy in cancer patients. Conclusions: 10 of 10 reviewed articles demonstrate evidence of the effectiveness of the administration of omega-3 fatty acids in reducing the adverse effects of chemotherapy in cancer patients; That is, evidence suggests a role for omega-3 fatty acid supplementation in cancer treatment, but they have been shown to preserve muscle mass and function in cancer patients.
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Efficacy of omega-3 fatty acids in preventing Parkinson’s disease risk in elderly adults
(Universidad Privada Norbert Wiener, 2020-01-19) Soto Reyes De Izquierdo, Yolanda María; Fernández Rengifo, Werther Fernando
OBJECTIVE: Systematize the evidence of the effectiveness of the consumption of omega-3 fatty acids in preventing the risk of Parkinson's disease in older adults. MATERIAL AND METHOD: The study has a systematic, observational and retrospective review design; of articles with full text, which identified their grade or quality of evidence according to the Grade System. Likewise, the sample was made up of 10 articles obtained from the following databases Pubmed, Medline, Embase, Cochrane Library, Dialnet, Scielo, and Lilacs. RESULTS: Of which 100% correspond to the design of randomized clinical studies, corresponding to the countries of the United States in 30%, Brazil 20%, Canada 10%, Spain 10%, Holland 10%, Iran 10% and Sweden 10 %. Of the 10 articles reviewed, 100% demonstrate that the consumption of omega-3 fatty acids is effective in preventing the risk of Parkinson's disease in older adults. CONCLUSIONS: The 10 articles showed that the consumption of omega-3 fatty acids is effective in preventing the risk of Parkinson's disease in older adults; That is, it prevents or delays the progression of neurodegenerative diseases, with beneficial effects that protect the brain, increasing the activity of glutathione reductase (enzyme that combats oxidative stress), which produces a lower accumulation of oxidized proteins, one of the problems of Parkinson.
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Revisión crítica: efecto de la suplementación con omega 3 en los marcadores inflamatorios durante el tratamiento al paciente con cáncer
(Universidad Privada Norbert Wiener, 2024-12-04) Vera Torres, Deborah Steffanny; Bohórquez Medina, Andrea Lisbet
El estudio analizó el impacto de la suplementación con omega-3 sobre los marcadores inflamatorios en pacientes con cáncer, empleando la metodología de Nutrición Basada en Evidencia. Se llevó a cabo una revisión bibliográfica exhaustiva en bases de datos como “PUBMED, EMBASE, SCIELO y SCIENCE DIRECT”, identificando un total de 14 estudios, de los cuales se seleccionaron 10 para su evaluación utilizando la herramienta de “lectura crítica CASPE”. Un ensayo clínico aleatorizado destacado, titulado "Terapia multidirigida del cáncer con ácidos grasos omega-3: una actualización", alcanzó el nivel de evidencia AII y recibió una recomendación firme. Los resultados obtenidos en los estudios sugieren que el omega-3 podría ser un recurso útil para contrarrestar la inflamación postquirúrgica en pacientes con cáncer gastrointestinal avanzado y ayudar a reducir los niveles de IL-6 y TNFR-2 en pacientes con cáncer de mama. Estos hallazgos dependen de la formulación, dosis y tiempo de suplementación, específica de omega-3, el tipo de cáncer y el estado nutricional del paciente. En conclusión, los resultados son variados, lo que resalta la necesidad de realizar investigaciones más profundas para obtener conclusiones más definitivas.
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Revisión crítica: efecto de la suplementación con omega-3 en los marcadores de inflamación en adultos con enfermedad renal crónica terminal
(Universidad Privada Norbert Wiener, 2024-11-20) Medina Pinto, Daniel Alcides; Ponce Castillo, Diana Antonia
La inflamación crónica es un mal que aqueja a los pacientes con enfermedad renal crónica terminal (ERCT). Esta afecta la calidad de vida y aumenta la mortalidad de esta población. La presente investigación secundaria titulada como: ―Revisión crítica: Efecto de la suplementación con omega-3 en la inflamación en adultos con ERCT‖ tuvo como objetivo realizar un comentario crítico profesional de acuerdo a la revisión de artículos científicos de estudios clínicos sobre el tema de suplementación con omega-3 e inflamación en pacientes con ERCT. La pregunta clínica fue: ¿Cuál es el efecto de la suplementación con omega-3 en los marcadores de inflamación en adultos con ERCT? Se utilizó la metodología Nutrición Basada en Evidencia (NuBE). La búsqueda de información se realizó en Pubmed, Science direct, Scopus, HINARI y Cochrane, encontrando 21 artículos, siendo seleccionados 10 que han sido evaluados por la herramienta para lectura crítica CASPE, seleccionándose finalmente el Ensayo Clínico Aleatorizado titulado ―Effect of Omega-3 Fatty Acids Supplementation on Homocysteine Level in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis‖; el cual posee un nivel de evidencia A I y Grado de Recomendación Fuerte, de acuerdo a la experticia del investigador. El comentario crítico permitió concluir que, es necesario realizar estudios más extensivos que incluyan dosis y tiempo de tratamiento adecuados de omega-3, para comprender mejor su efecto en la inflamación en pacientes con ERCT.
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Revisión crítica: efecto de la suplementación con omega-3 en pacientes adultos con cáncer de colon en radioterapia
(Universidad Privada Norbert Wiener, 2024-10-02) Justo Acosta, Mirtha Kely; Bohórquez Medina, Andrea Lisbet
La intervención nutricional es crucial porque mejora la eficacia y el criterio en el tratamiento clínico de diversas patologías. El estudio secundario que lleva por título "Revisión crítica: ¿Cuál es el efecto de la suplementación con omega-3 en pacientes adultos con cáncer de colon en radioterapia?" persiguió el objetivo de evaluar la reacción de los pacientes adultos ante la suplementación con omega-3 durante la radioterapia, dado el significativo desmejoramiento del estado nutricional y la salud general del paciente. La pregunta clínica planteada fue: ¿Es efectiva la suplementación con omega-3 en pacientes adultos con cáncer de colon que reciben radioterapia? Se adoptó un enfoque metodológico de Nutrición Basada en Evidencia (NuBE). Los datos se recopilaron de fuentes como PubMed, Science Direct, British Journal of Surgery, SciELO, Dialnet, Redalyc y finalmente BVS, encontrando 15 artículos en total. De estos, se seleccionaron 9 para su evaluación utilizando la herramienta CASPE. El modelo principal fue el Ensayo Clínico Aleatorizado titulado “Resultados a largo plazo después del tratamiento perioperatorio con suplementos de ácidos grasos omega- 3 en el cáncer colorrectal”, que posee un nivel de evidencia BI y un Grado de Recomendación Débil, de acuerdo con la valoración del investigador. El análisis crítico llegó a la conclusión de que hace falta más estudios para determinar de manera más precisa la respuesta a este nutriente para esta patología con una muestra poblacional más amplia.
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Revisión crítica: efecto de la suplementación de ácidos grasos omega 3 en la escala de severidad de mucositis oral en pacientes adultos oncológicos
(Universidad Privada Norbert Wiener, 2025-05-14) Vivanco Córdova, Keyla Yadira; Bohórquez Medina, Andrea Lisbet
La mucositis oral (MO) es un daño inflamatorio de la mucosa que recubre el revestimiento interno de cavidad oral como la lengua, las encías, el paladar y la garganta. La MO es una causa común en los tratamientos médicos oncológicos (quimioterapia y radioterapia) de cabeza y cuello. Según la OMS (Organización Mundial de la Salud) se clasifican por grados de severidad. La literatura reporta distintos suplementos que mitiguen este efecto secundario en pacientes adultos sometidos a quimioterapia se considera nutrición suplementaria con ácidos grasos Omega 3 como un blanco estratégico. El objetivo principal fue elaborar un análisis crítico desde una perspectiva profesional, fundamentado en la investigación de la literatura asociada nutrición suplementaria con ácidos grasos. omega-3, enfocados en aliviar los indicadores de severidad de la mucositis oral en pacientes adultos con diagnóstico oncológico. Se adoptó la metodología de Nutrición Basada en Evidencia (NuBE) para orientar el curso del análisis. El escrutinio de artículos se llevó a cabo en plataformas académicas como PUBMED, SCIELO, SCIENCE DIRECT y REDALYC, identificándose 32 trabajos relevantes. De estos, se seleccionará 11 para su valoración a través de la herramienta de análisis crítico CASPE, seleccionando por último el Ensayo Clínico Aleatorizado titulado : “Omega 3 nanoemulgel in prevention of radiation-induced oral mucositis and its associated effect on microbiome: a randomized clinical trial”, el estudio obtuvo una clasificación de nivel de evidencia AI, avalado por la experiencia del investigador. Producto del análisis crítico se puede sostener que la nutrición suplementaria con ácidos grasos omega-3 es una alternativa segura para reducir la severidad de la mucositis oral.
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Revisión crítica: efecto de la suplementación de ácidos grasos poliinsaturados omega 3 en el nivel de alfa treonina quinasa (AKT1) en pacientes pediátricos oncológicos con quimioterapia
(Universidad Privada Norbert Wiener, 2025-07-17) Santamaria Arce, Williams Manuel; Bohórquez Medina, Andrea Lisbet
La enzima alfa treonina quinasa (AKT1), tiene un papel crucial en el cáncer al regular la sobrevivencia, incremento y crecimiento de las células neoplásicas, promoviendo su desarrollo y renuencia a la apoptosis. Los ácidos grasos omega-3 desempeñan una parte trascendente al graduar los niveles de AKT1 en el contexto neoplásico, se ha demostrado que tienen la capacidad de regular a la baja los niveles de AKT1 en células cancerosas. Esto sugiere que los omega-3 podría ser beneficioso como terapia de apoyo en el tratamiento del cáncer, al suprimir la actividad de AKT1 y, por lo tanto, inhibir el crecimiento y progresión tumoral. El presente trabajo tenía como propósito hacer el análisis crítico profesional conforme con las investigaciones clínicas sobre el omega 3 y los niveles de AKT1. La búsqueda se realizó en PUBMED, SCIENCE DIRECT, Redalyc, hallando 24, de los cuales 12 fueron evaluados con CASPE. Finalmente, se seleccionó el Ensayo Clínico Aleatorizado: “Omega-3 supplementation to reduce alpha threonine kinase (AKT1) levels in children with acute lymphoblastic leukemia (ALL) in the induction phase of chemotherapy”, al cual se le otorgó el nivel más alto de evidencia luego de la lectura crítica. La valoración final nos permite concluir que es seguro suplementar con ácidos grasos poliinsaturados Omega 3 en pacientes pediátricos que reciben quimioterapia.