Examinando por Materia "Fluoxetine"

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Acceso abierto
Actividad antidepresiva del extracto etanólico de las hojas de Manihot esculenta Cranz “yuca” en ratones
(Universidad Privada Norbert Wiener, 2023-02-20) Gallardo Delgado, Shirley Jasmin; Justil Guerrero, Hugo Jesús
Depression is a mood disorder characterized by feelings of sadness, with episodes lasting weeks or months, often leading to suicidal thoughts. According to the "WHO," this disease is very common worldwide, affecting more than 280 million people. Over half of those affected do not receive treatment due to a lack of resources or misdiagnosis. Objective: The present study aimed to evaluate the antidepressant activity of the ethanolic extract of Manihot esculenta Cranz leaves ("cassava") in mice. Methodology: The study was experimental and quantitative. The leaves were collected in the district of La Merced, Province of Chanchamayo, Department of Junín. Secondary metabolites of the ethanolic extract were identified. The antidepressant activity (AAD) was evaluated using the forced swimming test in 30 albino mice at doses of 50, 100, and 200 mg/kg of the ethanolic extract administered orally, compared to fluoxetine at 20 mg/kg. Immobility time, swimming time, and climbing time were measured over 15 minutes. Results: The lowest average immobility time was observed in the group treated with the ethanolic extract at 200 mg/kg, with 13.5 seconds, while the control group showed a significantly higher immobility time of 104.2 seconds. The swimming time was highest in the group treated with 200 mg/kg of the ethanolic extract, averaging 177.5 seconds, as was the climbing time, averaging 49.0 seconds. Conclusion: The ethanolic extract at a concentration of 200 mg/kg has antidepressant activity comparable to fluoxetine.