Examinando por Materia "Fusobacterium nucleatum"

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Critical review: relationship of fusobacterium nucleatum in the development of colorectal cancer.
(Universidad Privada Norbert Wiener, 2021-06-04) Meléndez Barzola, Carlos Enrique; Bohórquez Medina, Andrea Lisbet
The World Health Organization (WHO) reports that colorectal cancer is the third leading cause of death worldwide, making it a public health issue due to its high incidence. This research, titled "Influence of intestinal dysbiosis on the development of colorectal cancer," was developed as a critical review. The objective was to evaluate the available scientific research through a critical reading using the Critical Appraisal Skills Programme (CASPE) tool on studies published about the influence of intestinal microbiome alterations (intestinal dysbiosis) in the development of colorectal cancer. The clinical question was: Does intestinal dysbiosis influence the development of colorectal cancer? The methodology used was Evidence-Based Nutrition (NuBE). The search for information was conducted in WEB OF SCIENCE, SCOPUS, EMBASE, PUBMED, SCIELO, DOAJ, SCIENCE DIRECT, ERIHPLUS, HINARIN, finding 114 articles, with 17 selected and evaluated using the CASPE tool. The systematic review titled "Fusobacterium nucleatum in the colorectum, and its association with cancer risk and survival: a systematic review and meta-analysis" was selected, with evidence level II and a strong recommendation grade, according to the researcher’s opinion. The critical commentary concludes that intestinal dysbiosis, especially the increase of Fusobacterium nucleatum, plays an important role in the development and prognosis of colorectal cancer. However, more clinical trials in humans are needed to establish Fusobacterium nucleatum as a causal factor or biomarker for development, which could generate low-cost diagnostic tools, as well as prophylactic and/or therapeutic measures.