Examinando por Materia "Gels"

Mostrando 1 - 4 de 4

Acceso abierto
Efecto cicatrizante del gel formulado a partir del extracto hidroalcohólico de Ligaria cuneifolia R&P., "suelda con suelda" en ratas
(Universidad Privada Norbert Wiener, 2021-12-07) Munares Cusi, Milton Ever; Cayao Regalado, Maribel Soledad; Alvarado Chávez, Britt
In Peru, medicinal plants are of great importance for research into new formulations due to being a natural alternative. Objective: To confirm the wound-healing effect of the gel formulated from the hydroalcoholic extract of Ligaria cuneifolia R&P., 'suelda con suelda,' in rats. Methodology: The plant species was collected in the San Pedro community, Puywas district, Huancayo department. A hydroalcoholic extraction of the Ligaria cuneifolia R&P leaves was performed. A solubility test and phytochemical screening were conducted. The wound-healing activity was executed using three gel concentrations (0.5%,5%, and 10%) prepared from the hydroalcoholic extract. This was compared with standard groups based on Contractubex® Gel (onion plant cells) and a base gel control group, culminating in the anatomopathological technique (histological sections of the healing skin tissue). Results: The existence of secondary metabolites such as flavonoids, tannins, and phenolic compounds was evidenced. Regarding the wound-healing effect, the gel based on the 10% hydroalcoholic extract of Ligaria cuneifolia R&P presented the highest healing efficacy (histologically, the presence of reparative changes, marked hyperplasia of basal cells, and superficial and deep dermis with moderate fibrosis and an increase in fibroblasts and cicatricial epithelium was observed). The histological findings showed scar reparative changes in the epidermis, with mild fibrosis in the dermis, indicating a good healing response. The healing degree was rated as Good, validating 80.6% efficacy compared to Contractubex®, which reached 70.6% efficacy. Conclusion: It was confirmed that the hydroalcoholic extract of Ligaria cuneifolia R&P 'suelda con suelda' presents wound-healing activity in rats.
Acceso abierto
Estudio de estabilidad de las formulaciones crema y gel elaborados con la fracción polar del extracto alcohólico de las hojas de Oenothera rosea L´Her. ex Aiton "chupasangre"
(Universidad Privada Norbert Wiener, 2018-06-09) Bellodas Castillo, Ronald Martín; Cano Salvador, Fanny Chris; Nué Martinez, Jorge Jonathan
This study conducted an accelerated stability study of two semi-solid pharmaceutical formulations—cream and gel—prepared with the polar fraction of the alcoholic extract from the leaves of Oenothera rosea L'Her. ex Aiton, "Chupasangre." The Peruvian regulations in force, according to Ministerial Resolution (R.M.) 805-2009-MINSA, were used for this study, evaluating the organoleptic characteristics (appearance, color, odor), viscosity, pH, the quantification of flavonoids as an indicator of extract concentration, and the microbial limit, based on climatic zone IVa. The results of the accelerated stability study for both pharmaceutical forms demonstrate that both products maintained the microbiological quality parameters. However, for the physicochemical parameters, only the cream showed conservation within the product specifications, while the gel suffered degradation at the end of the study.
Acceso abierto
Formulación de fármaco por nueva vía de administración: Closantel Sódico, gel antiparasitario de uso veterinario contra Fasciola hepática
(Universidad Privada Norbert Wiener, 2015) Zegarra Cárdenas, Diana; Rivas Altez, Walter
The study was carried out with the purpose of formulating a medicine through a new route of administration of sodium closantel gel for veterinary use against Fasciola hepatica during the months of January to April 2015. An experimental, analytical, cross-sectional research work was conducted to elaborate a gel that meets the optimal conditions for use as an antiparasitic, taking into account the ideal physicochemical processes for the formulation of the gel in question. It should be noted that the physicochemical processes are important in the elaboration of the gel, with the fundamental basis being the interaction of the appropriate excipients, the active ingredient, adequate quantity, etc. Several excipients were considered for the preparation of the gel, finding that the use of Cremophor in different amounts is not suitable for the gel formulation. The use of Tween 80, which is employed for viscosity, is also not suitable for the gel formulation as it presented non-ideal characteristics. Poligel was used for the formulation of the gel, and incompatibilities and inconsistencies were found (Not suitable). Formula 1012 was used, in which it was observed that the use of 80 g is adequate for the gel formulation (Suitable). A formula with codification 1012 was also used, where the ideal temperature for the formulation of the gel is 70°C. The use of Polyethylene glycol in an amount of 200 mL is adequate for the formulation of the gel. In the search for alcohols for the gel formulation it was found that: the use of rectified ethanol alcohol in an amount of 100 mL is suitable, alcohol coded (1013) in an amount of 100 mL is suitable, alcohol coded (1014) in an adequate amount of 200 mL, and formula coded (1015) in an amount of 15 mL is suitable. The use of Monoethanolamine in an amount of 8.5 mL is optimal for the gel formulation. It should also be noted that the active ingredient sodium closantel does not present any inconvenience in the formulation of the gel.
Acceso abierto
Formulación de un gel a partir del extracto etanólico de las hojas de Mangifera indica L. "mango" con efecto antiinflamatorio en ratones
(Universidad Privada Norbert Wiener, 2021-05-22) Laureano Soca, Cielo Lucero; Chacaltana Pérez, Mercedes Tathiana; Chávez Flores, Juana Elvira
Currently, the production of phytopharmaceuticals or natural products with pharmacological properties often lacks scientific study to validate their medicinal uses and ensure they are free from microorganisms harmful to public health. The objective of this study was to confirm the anti-inflammatory effect of a gel formulated from the ethanolic extract of Mangifera indica L. ('Mango') leaves. Methodology: An experimental pharmacological study was conducted to evaluate the anti-inflammatory effect of the gel using the ear edema method in mice. The mice were randomly distributed into six groups of five, with noxa induced by xylene. The anti-inflammatory effect was compared with 1% diclofenac gel. In parallel, an accelerated stability study of the test gel was performed, evaluating organoleptic characteristics, pH, and microbial limit. Results: The 2.4% gel demonstrated similar effectiveness to the 1% diclofenac gel, with inflammation inhibition of 35.46% and 32.91%, respectively. The stability study evidenced that the 1.2% gel maintained better preservation at the end of the study period. Conclusion: It was confirmed that the gel derived from the ethanolic extract of the leaves of Mangifera indica L. 'Mango' has anti-inflammatory effectiveness via topical administration.