Examinando por Materia "Heparina de Bajo-Peso-Molecular"

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    Effectiveness of unfractionated heparins versus low-molecular-weight heparins for the prevention of coagulation in patients with renal insufficiency undergoing hemodialysis.
    (Universidad Privada Norbert Wiener, 2018-11-04) Rosado Gereda, Johana Lizbeth; Vicente Velasquez, Víctor Andrés; Borda Izquierdo, Alejandro
    Objective: A systematic review of ten scientific articles was conducted, with a publication date of less than ten years, from the following databases: Scielo, Pubmed, Epistemonikos, Medline, and Google Scholar. Of the selected articles, 20% were systematic reviews and meta-analyses, 40% were randomized clinical trials, 20% cohort studies, and 20% case-control studies. The overall quality of evidence was high in 70% of the articles and moderate in 30%. The studies originated from the following countries: USA (30%), Canada (20%), Brazil (10%), Austria (10%), Israel (10%), Poland (10%), and the UK (10%). The GRADE system was used to identify the level of evidence. Results: According to the findings, 60% (n = 6/10) indicated that both heparins are equally effective in preventing coagulation in patients with renal failure undergoing hemodialysis. 30% (n = 3/10) suggested that low-molecular-weight heparin is more effective than unfractionated heparin, and 10% (n = 1/10) indicated that unfractionated heparin is more effective than low-molecular-weight heparin. Conclusions: Unfractionated heparin is as effective as low-molecular-weight heparin in preventing coagulation in patients with renal failure undergoing hemodialysis treatment.