Examinando por Materia "Hipertensión Intracraneal"

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    Effectiveness of mannitol treatment compared to hypertonic saline solution in patients with intracranial hypertension
    (Universidad Privada Norbert Wiener, 2018-07-08) Astete Osorio, Sherly Kety; Fernández Carlos, Marilyn Sayuri; Rivera Lozada de Bonilla, Oriana
    Objective: To systematize the evidence on the effectiveness of mannitol treatment compared to hypertonic saline solution for reducing intracranial pressure in patients with intracranial hypertension. Material and Method: This systematic review is quantitative. Searches were conducted in various databases, from which 10 articles were selected: 3 meta-analysis designs, 5 systematic reviews, and 2 controlled clinical trials. All articles were evaluated using the GRADE system. Results: Of the total 10 articles, 80% (8/10) show that the use of hypertonic saline solution is more effective in treating intracranial hypertension, while 20% (2/10) show that both osmotic agents present heterogeneous results in treating intracranial hypertension. Conclusions: The systematic review provides evidence that 8 out of 10 articles demonstrate that hypertonic saline solution is more effective than mannitol in controlling intracranial pressure, maintaining stable systemic and cerebral hemodynamics, improving relaxation and cerebral perfusion, and reducing secondary sequelae. However, 2 out of 10 articles show that both osmotic agents have heterogeneous results in treating intracranial hypertension.