Examinando por Materia "Hypnotics and Sedatives"

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Actividad sedante y ansiolítico del extracto etanólico de las hojas de Ruta chalepensis L. “ruda” en ratones
(Universidad Privada Norbert Wiener, 2018-06-05) Alvarado Lopez, Lesly Lizeth; Castro Bolaños, Cinthia Melissa; Chávez Flores, Juana Elvira
Ruta chalepensis L., "Ruda," is a plant widely distributed in the Mediterranean region and used in folk medicine as an antispasmodic, anthelmintic, antimicrobial, emmenagogue, and abortifacient. The plant species was collected in the Lima department, Lurín district, at 1224 m.a.s.l.. In this experimental study, the sedative and anxiolytic effect of the ethanolic extract from the leaves of Ruta chalepensis L., "Ruda," was confirmed in mice. A qualitative phytochemical profile was conducted. Subsequently, the study methods began: Sodium Pentobarbital-induced Sleep at different concentrations (100,250, and 500 mg/kg) and the Marble Burying Test at doses of 5,10, and 15 mg/kg. A total of 100 albino Balb/C53 strain mice of both sexes were used and distributed into five groups. It was confirmed that the most effective treatment in the Marble Burying Test was the ethanolic extract of Ruta chalepensis L., 'Ruda,' at 10 and 15 mg/kg, showing an effect superior to diazepam. Regarding the Sodium Pentobarbital-induced Sleep method, the comparison of the extracts versus diazepam indicates that the ethanolic extracts of Ruda at 250 and 500 mg/kg primarily have an effect similar to diazepam. Conclusion: The ethanolic extract from the leaves of Ruta chalepensis L., "Ruda," does possess sedative and anxiolytic activity.
Acceso abierto
Efecto sedante y ansiolítico del extracto hidroalcohólico de las hojas de Solanum corneliomulleri J.F. Macbr. “Sandillón” en ratones
(Universidad Privada Norbert Wiener, 2022-07-09) Castañeda Campos, Elsa Rosario; Castañeda Campos, Willy German; Ramos Jaco, Antonio Guillermo
The sedative and anxiolytic effects of medicinal plants constitute a safe alternative for the treatment of diseases associated with depression. Objective: To demonstrate the sedative and anxiolytic effects of the hydroalcoholic extract of the leaves of Solanum corneliomulleri J.F. Macbr. (“sandillón”) in mice. Methods: This was an experimental, prospective study. Secondary metabolites in the leaves were determined qualitatively. To demonstrate the sedative effect, the pentobarbital sodium-induced sleep method was employed, comparing extract doses of 100, 250, and 500 mg/kg. To demonstrate the anxiolytic effect, the hole-board method was used, comparing extract doses of 5, 10, and 15 mg/kg. Two groups of 40 male albino mice of the Balb/C53/CNPB strain were used: a negative control group receiving distilled water and a positive control group receiving diazepam at 10 mg/kg. Results: The 250 mg/kg extract dose produced the longest average sleep duration (2.8 hours), showing the greatest sedative effect. The 15 mg/kg dose produced the highest anxiolytic effect. Both effects were statistically significant, although slightly lower compared to the diazepam 10 mg/kg control group. The sedative effect of the hydroalcoholic extract at doses of 100, 250, and 500 mg/kg was 70.3%, 82.4%, and 81.6%, respectively, compared with diazepam 10 mg/kg. The anxiolytic effect at 10 mg/kg extract dose exceeded diazepam, showing an anxiety inhibition of 59.7%. The presence of alkaloids and other secondary metabolites was identified, which may be associated with the sedative and hypnotic effect. Conclusion: The hydroalcoholic extract of Solanum corneliomulleri leaves exhibits sedative and anxiolytic effects at doses of 100, 250, and 500 mg/kg, showing significant pharmacological activity, though slightly lower than diazepam. The presence of alkaloids and other metabolites suggests a possible mechanism for the observed effects.