Examinando por Materia "International Normalized Ratio"

Seleccione resultados tecleando las primeras letras
Mostrando 1 - 2 de 2
  • Miniatura
    ÍtemAcceso abierto
    Relationship between the dose of Warfarin, INR and protein S in anti-coagulant patients at Hospital III Yanahuara – EsSalud Arequipa. 2023 - 2024
    (Universidad Privada Norbert Wiener, 2023-11-05) Albornos Andrade, Christiam Efrain; Huamán Cárdenas, Victor Raul
    Warfarin anticoagulant treatment is limited to monitoring the INR, a value obtained through the Prothrombin test requested by doctors, especially for patients who have had thrombotic events for various reasons. Currently, in the Arequipa region, it is the most widely used method for pharmacological monitoring, adjusting doses to avoid adverse events for the patient. What is not evaluated is the action of this drug on other proteins involved in the hemostatic control process, such as protein S.
  • Miniatura
    ÍtemAcceso abierto
    Systematic Review on the Influence of Grapefruit Juice on the International Normalized Ratio (INR) in Anticoagulated Patients
    (Universidad Privada Norbert Wiener, 2017-12-20) Vargas Machuca Vera, Luis Enrique; Melgarejo Gonzales, Marycarmen; Benites Azabache, Juan Carlos
    The objective was to establish the influence of grapefruit juice on the international normalized ratio (INR) values in patients using oral anticoagulants. For the systematic review, searches were conducted in PUBMED, LILACS, ESSALUD VIRTUAL LIBRARY, and TRIPDATABASE, which evaluate the influence of grapefruit juice on INR values in patients with oral anticoagulants. A search strategy was developed using keywords, Boolean operators, truncations, among others. Fifteen original articles were found based on the inclusion criteria and risk of bias, with more than 60% adherence to the checklist developed by CASPe. Two articles were selected to carry out the systematic review. In conclusion, grapefruit juice consumption during anticoagulant treatment increases INR values, as it inhibits CYP3A4, altering the metabolism of anticoagulants, although the true clinical effect is often debated. Proper controlled studies are needed to fully determine whether a causal relationship exists.