Examinando por Materia "Loranthaceae"

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    Efecto cicatrizante del gel formulado a partir del extracto hidroalcohólico de Ligaria cuneifolia R&P., "suelda con suelda" en ratas
    (Universidad Privada Norbert Wiener, 2021-12-07) Munares Cusi, Milton Ever; Cayao Regalado, Maribel Soledad; Alvarado Chávez, Britt
    In Peru, medicinal plants are of great importance for research into new formulations due to being a natural alternative. Objective: To confirm the wound-healing effect of the gel formulated from the hydroalcoholic extract of Ligaria cuneifolia R&P., 'suelda con suelda,' in rats. Methodology: The plant species was collected in the San Pedro community, Puywas district, Huancayo department. A hydroalcoholic extraction of the Ligaria cuneifolia R&P leaves was performed. A solubility test and phytochemical screening were conducted. The wound-healing activity was executed using three gel concentrations (0.5%,5%, and 10%) prepared from the hydroalcoholic extract. This was compared with standard groups based on Contractubex® Gel (onion plant cells) and a base gel control group, culminating in the anatomopathological technique (histological sections of the healing skin tissue). Results: The existence of secondary metabolites such as flavonoids, tannins, and phenolic compounds was evidenced. Regarding the wound-healing effect, the gel based on the 10% hydroalcoholic extract of Ligaria cuneifolia R&P presented the highest healing efficacy (histologically, the presence of reparative changes, marked hyperplasia of basal cells, and superficial and deep dermis with moderate fibrosis and an increase in fibroblasts and cicatricial epithelium was observed). The histological findings showed scar reparative changes in the epidermis, with mild fibrosis in the dermis, indicating a good healing response. The healing degree was rated as Good, validating 80.6% efficacy compared to Contractubex®, which reached 70.6% efficacy. Conclusion: It was confirmed that the hydroalcoholic extract of Ligaria cuneifolia R&P 'suelda con suelda' presents wound-healing activity in rats.