Examinando por Materia "Manitol"

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Acceso abierto
Effectiveness of mannitol treatment compared to hypertonic saline solution in patients with intracranial hypertension
(Universidad Privada Norbert Wiener, 2018-07-08) Astete Osorio, Sherly Kety; Fernández Carlos, Marilyn Sayuri; Rivera Lozada de Bonilla, Oriana
Objective: To systematize the evidence on the effectiveness of mannitol treatment compared to hypertonic saline solution for reducing intracranial pressure in patients with intracranial hypertension. Material and Method: This systematic review is quantitative. Searches were conducted in various databases, from which 10 articles were selected: 3 meta-analysis designs, 5 systematic reviews, and 2 controlled clinical trials. All articles were evaluated using the GRADE system. Results: Of the total 10 articles, 80% (8/10) show that the use of hypertonic saline solution is more effective in treating intracranial hypertension, while 20% (2/10) show that both osmotic agents present heterogeneous results in treating intracranial hypertension. Conclusions: The systematic review provides evidence that 8 out of 10 articles demonstrate that hypertonic saline solution is more effective than mannitol in controlling intracranial pressure, maintaining stable systemic and cerebral hemodynamics, improving relaxation and cerebral perfusion, and reducing secondary sequelae. However, 2 out of 10 articles show that both osmotic agents have heterogeneous results in treating intracranial hypertension.
Acceso abierto
Effectiveness of the use of mannitol versus hypertonic solution in neurocritical patients with brain injuries
(Universidad Privada Norbert Wiener, 2017-08-05) Maza Chavez, Evelin Flor; Pachas Cordova, Wendy Cecilia; Pérez Siguas, Rosa Eva
Objective: To analyze and synthesize the evidence on the efficacy of mannitol versus hypertonic solution in neurocritical patients with brain injuries. Materials and methods: This systematic review is observational and retrospective. Searches were conducted across various databases, but finally, articles with full text were selected and critically reviewed, using the GRADE assessment to identify the level of evidence. Results: Of the 10 articles reviewed, 9/10 articles show that the use of hypertonic solution has greater efficacy in managing neurocritical patients with brain injuries, accounting for 90%. Among these, 10% of the articles do not consider the data sufficient to define the efficacy between these treatments. Conclusions: The systematic review demonstrated that hypertonic solution is more effective in neurocritical patients with brain injuries, showing better cerebral perfusion and increasing the survival rate of the neurocritical patient.
Acceso abierto
EFICACIA DEL USO DEL MANITOL VERSUS LA SOLUCION HIPERTONICA EN PACIENTES NEUROCRITICOS CON LESIONES CEREBRALES
(Universidad Privada Norbert Wiener, 2017) Maza Chavez, Evelin Flor; Pérez Siguas, Rosa Eva
OBJETIVO: Analizar y sintetizar las evidencias sobre la eficacia del uso del manitol versus la solución hipertónica en pacientes neurocríticos con lesiones cerebrales. MATERIAL Y METODO: La presente revisión sistemática es de tipo observacional y retrospectivo, se realizaron búsquedas de diversas bases de datos, pero finalmente se ha seleccionado a los artículos con texto completo, y los artículos se sometieron a una lectura crítica, utilizando la evaluación GRADE para identificar su grado de evidencia. RESULTADOS: De Los 10 artículos revisados, 9/10 artículos muestran que el uso de la solución hipertónica tiene mayor eficacia en manejo de pacientes neurocríticos con lesiones cerebrales considerándose un 90%, de los cuales encontramos que el 10% no consideran los datos suficientes para llegar a definir la eficacia entre uno de estos tratamientos. CONCLUSIONES: Con la revisión sistemática realizada se evidencio que existe mayor eficacia en el uso de solución hipertónica en pacientes neurocriticos con lesiones cerebrales mostrando de esta manera mejor perfusión a nivel cerebral y elevando el porcentaje de vida del paciente neurocritico.