Examinando por Materia "Mannitol"

Seleccione resultados tecleando las primeras letras
Mostrando 1 - 2 de 2
  • Miniatura
    ÍtemAcceso abierto
    Effectiveness of mannitol treatment compared to hypertonic saline solution in patients with intracranial hypertension
    (Universidad Privada Norbert Wiener, 2018-07-08) Astete Osorio, Sherly Kety; Fernández Carlos, Marilyn Sayuri; Rivera Lozada de Bonilla, Oriana
    Objective: To systematize the evidence on the effectiveness of mannitol treatment compared to hypertonic saline solution for reducing intracranial pressure in patients with intracranial hypertension. Material and Method: This systematic review is quantitative. Searches were conducted in various databases, from which 10 articles were selected: 3 meta-analysis designs, 5 systematic reviews, and 2 controlled clinical trials. All articles were evaluated using the GRADE system. Results: Of the total 10 articles, 80% (8/10) show that the use of hypertonic saline solution is more effective in treating intracranial hypertension, while 20% (2/10) show that both osmotic agents present heterogeneous results in treating intracranial hypertension. Conclusions: The systematic review provides evidence that 8 out of 10 articles demonstrate that hypertonic saline solution is more effective than mannitol in controlling intracranial pressure, maintaining stable systemic and cerebral hemodynamics, improving relaxation and cerebral perfusion, and reducing secondary sequelae. However, 2 out of 10 articles show that both osmotic agents have heterogeneous results in treating intracranial hypertension.
  • Miniatura
    ÍtemAcceso abierto
    Effectiveness of the use of mannitol versus hypertonic solution in neurocritical patients with brain injuries
    (Universidad Privada Norbert Wiener, 2017-08-05) Maza Chavez, Evelin Flor; Pachas Cordova, Wendy Cecilia; Pérez Siguas, Rosa Eva
    Objective: To analyze and synthesize the evidence on the efficacy of mannitol versus hypertonic solution in neurocritical patients with brain injuries. Materials and methods: This systematic review is observational and retrospective. Searches were conducted across various databases, but finally, articles with full text were selected and critically reviewed, using the GRADE assessment to identify the level of evidence. Results: Of the 10 articles reviewed, 9/10 articles show that the use of hypertonic solution has greater efficacy in managing neurocritical patients with brain injuries, accounting for 90%. Among these, 10% of the articles do not consider the data sufficient to define the efficacy between these treatments. Conclusions: The systematic review demonstrated that hypertonic solution is more effective in neurocritical patients with brain injuries, showing better cerebral perfusion and increasing the survival rate of the neurocritical patient.