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    Immunophenotypic profile of breast cancer and its relationship with serum CA 15-3 level, Arzobispo Loayza National Hospital, 2024
    (Universidad Privada Norbert Wiener, 2024-07-21) Zanabria Villar, Nathaly Esther; Cabrejos Chilge, Gabriel Emigdio
    Introduction: Breast cancer constitutes a global health problem. In Peru, it is the second most frequent cancer among women. According to the expression of immunohistochemical markers, we can know four subtypes (Luminal A, Luminal B, HER2 positive, and triple-negative), which, together with the serological value of the tumor marker CA 15-3, helps detect recurrent breast cancer and monitor the treatment of women with advanced breast cancer. Objective: To analyze the relationship between the immunophenotypic profile of breast cancer and the serum level of CA 15-3 in patients treated at the Hospital Nacional Arzobispo Loayza, 2019. Materials and Methods: A correlational, non-experimental, quantitative, basic, observational cross-sectional study. The study population consisted of clinical histories of patients with a positive breast cancer diagnosis with their respective immunophenotypic profile and serum CA 15-3 results, treated at the Hospital Nacional Arzobispo Loayza from January 1 to December 31, 2019. Data were collected on a previously designed form and analyzed using statistical programs (SPSS version 2023, Kolmogorov-Smirnov normality test, Spearman's Chi-Squared test). Results: 44.29% of women had the Luminal A subtype, 27.14% Luminal B, 14.29% triple-negative, and 14.29% HER2. Additionally, 88.57% had a normal serum CA 15-3 level, and 11.43% had an elevated level. Conclusions: No significant differences were found between the immunophenotypic profile of breast cancer and serum CA 15-3 levels, according to Spearman's Rho (P > 0.05).