Examinando por Materia "Myrtus cheken"

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Acceso abierto
Efecto antiinflamatorio del extracto hidroalcohólico de las hojas de Luma Chequen (Molina) A. Gray “Arrayán” mediante el método de edema subplantar en ratas
(Universidad Privada Norbert Wiener, 2019-12-02) Linares Martínez, Dámaris Rosana; Chávez Flores, Juana Elvira
The objective of this research was to confirm the anti-inflammatory effect of the hydroalcoholic extract from the leaves of Luma chequen (Molina) A. Gray, 'arrayán,' using the subplantar edema method in rats. Materials and methods: Solubility and qualitative analyses were performed. To determine the anti-inflammatory effect, a modified subplantar edema method with a 1% albumin solution was used. 48 albino rats (Holtzman strain), with an average weight of 200-250g, were acclimated for 7 days and randomly distributed into six groups of eight. Afterward, 0.1 mL of a 1% albumin solution was applied to the subplantar area. The hydroalcoholic extract was used at doses of 200, 400, and 600 mg/kg of body weight, and dexamethasone (4 mg/kg) and diclofenac (50 mg/kg) were used as standard drugs. Results: The hydroalcoholic extract showed solubility in distilled water, ethanol, and methanol. The qualitative analysis confirmed the presence of flavonoids, phenols, tannins, alkaloids, coumarins, and steroids and/or triterpenoids. In the anti-inflammatory effect evaluation, the extract at a dose of 200 mg/kg showed an inflammatory inhibition of 82.3% at the sixth hour, which was greater than diclofenac's 77.1% and comparable to dexamethasone's 90.1%. Conclusions: The anti-inflammatory effect of the hydroalcoholic extract from the leaves of Luma chequen (Molina) A. Gray, 'arrayán,' was confirmed. At a dose of 200 mg/kg, its effect was greater than diclofenac's and comparable to dexamethasone.