Examinando por Materia "Olanzapine"

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    Effectiveness of quetiapine compared to olanzapine in the decrease of adverse reactions in patients with schizophrenia in the emergency service.
    (Universidad Privada Norbert Wiener, 2018-11-25) Pacheco Pariona, Haydeé; Villanueva Sandoval, Diana Carolina; Rivera Lozada de Bonilla, Oriana
    Objective: Systematize the evidence on the effectiveness of quetiapine compared to olanzapine in reducing adverse reactions in patients with schizophrenia in the emergency department. Materials and Methods: Quantitative study with a systematic review design, the search of 80 was restricted to full-text articles, and the 10 selected articles underwent critical reading, using the GRADE assessment to identify their level of evidence. Results: In the final selection, 10 articles were chosen, with 70% being clinical trials and 30% systematic reviews, 80% of them from Spain, and 20% from Berlin. Conclusions: It was evidenced in 60% of the studies that quetiapine is more effective than olanzapine due to the improvement of cognitive function, reaction quality/attention, shorter interruption time, fewer movement disorders, slight weight gain, fewer parkinsonian effects, and better tolerance; while olanzapine produces weight gain, insulin resistance, metabolic effects, extrapyramidal effects, increased cholesterol and triglycerides, and QT wave alterations.