Examinando por Materia "Pharmacokinetics"

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Acceso abierto
Evaluación y análisis de las interacciones medicamentosas en prescripciones médicas atendidas a pacientes ambulatorios período enero–julio 2021: revisión sistemática
(Universidad Privada Norbert Wiener, 2021-08-04) Cusipuma Lozano, Meylin Liset; Yslache Neyra, Lizbeth Thalia; Torres Veliz, Ernesto Raúl
A drug interaction occurs when the effect of a drug is altered by the administration of another, which can cause adverse reactions, putting the patient's health at risk. The objective of this research was to evaluate and analyze studies of drug interactions in medical prescriptions filled for outpatient patients. The study was basic, descriptive, with a retrospective and cross-sectional directionality. Data were collected from research published over the last 10 years on drug interactions in prescriptions for outpatient patients. The results were analyzed based on severity, type of interaction, type of documentary evidence, and frequency of interaction using a data collection form. Results: The predominant drug interactions by severity were moderate (62.4%). By type of documentary evidence, 'Good' predominated at 50.7%. By type of interaction, pharmacodynamic predominated at 53.6%, and by frequency, the most common was once (46%). Conclusion: It is important that a pharmacist be present in pharmaceutical establishments to detect possible drug interactions.
Acceso abierto
Interacciones medicamentosas potenciales y factores asociados en prescripciones médicas de pacientes del Hospital Hermilio Valdizan periodo 2019–2020
(Universidad Privada Norbert Wiener, 2022-01-17) Gallardo Vivar, Kattya Zenaida; Torres Veliz, Ernesto Raúl
The main objective of this study was to analyze Potential Drug-Drug Interactions (PDDIs) and associated factors in medical prescriptions for patients served at the Hermilio Valdizan Hospital pharmacy from 2019 to 2021. The methodology used a deductive approach, moving from general ideas to specific ones. It had a quantitative approach, with a basic research type, and a descriptive, non-experimental, retrospective, and cross-sectional design. The study population consisted of 73,810 medical prescriptions, from which a sample of 246 was extracted. Inclusion criteria considered prescriptions handled by the Hermilio Valdizan Hospital pharmacy. Data analysis was the study technique, and electronic devices using the platform https://drugs.com/drug_interactions.html were employed as the instrument for medical prescriptions. The variables studied were: number of interactions, severity, type of interaction, number of medications, age, and sex. Results demonstrated that 67.1% of the sample was female and 32.9% was male. Conclusion: 76.83% of the total sample presented pharmacodynamic PDDIs, while 23.17% had pharmacokinetic PDDIs.