Examinando por Materia "Phoradendron"

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Acceso abierto
Evaluación de la actividad cicatrizante del extracto etanólico de las hojas de Phoradendron peruvianus (Eichler) "tullma" en ratas Holtzman
(Universidad Privada Norbert Wiener, 2020-08-26) Torres Contreras, Ruth; Molina Campos, Sendy Bell; Chávez Flores, Juana Elvira
Skin lesions are a significant problem today. Wound-healing treatments are often scarce and expensive, so this research aims to encourage the development of natural, accessible, and reliable treatments for the population. The objective was to evaluate the wound-healing activity of the ethanolic extract from the leaves of Phoradendron peruvianus (Eichler), 'Tullma,' in Holtzman rats. The study sample was the ethanolic extract from the leaves of Phoradendron peruvianus (Eichler). A total of 48 Holtzman rats were assigned to six work groups. Method: The modified Vaisberg et al. (1989) method for second-intention wounds was adapted and used for this study. Results: According to the diameter of the wound closure on the rats' backs, the group treated with the 5% gel showed a healing activity of 59%. In the histopathological evaluation of the healing tissue, 87.5% of the group treated with the 5% gel showed complete healing, compared to Contractubex, which showed 63%. Conclusion: The extract did show wound-healing activity, both in wound closure and in the histopathological study, with the group treated with the 5% gel showing a higher percentage compared to the positive control.
Acceso abierto
Evaluación de la actividad cicatrizante y toxicidad dérmica del gel a base del extracto etanólico de la corteza de Calycophyllum spruceanum (Benth.) Hook. f. ex K. Schum “capirona” en ratas albinas Holtzman
(Universidad Privada Norbert Wiener, 2021-03-12) Gamboa Ortiz, Milagros Ruth; Miranda Rivera, Estefani Samantha; Chávez Flores, Juana Elvira
The use of medicinal plants is important due to their low cost. Materials and Method: The plant species was collected in Ucayali, Peru. An ethanolic extraction of the bark of Calycophyllum spruceanum (Benth) Hook. f. ex Schum. was performed. The wound-healing activity was assessed using the Vaisberg et al. technique, for which three gels based on the plant species were prepared at concentrations of 1,2, and 4%. These were compared with two standard groups: a 10% gel (containing plant strain extract, sodium heparin, and allantoin) named "Contratubex," and a control group. Dermal toxicity was determined using the Contero R technique, where a single oral and dermal dose of 5000 mg/kg of the extract was administered to rats. Results: Qualitative analysis determined that the extract is soluble in distilled water and contains primary and secondary metabolites, such as flavonoids and tannins. Regarding wound-healing activity, the 1% concentration gel achieved the highest healing efficacy of 90%. In the toxicological evaluation, no rat showed dermal toxicity. Conclusion: It was determined that the ethanolic extract from the bark of Calycophyllum spruceanum (Benth) Hook. f. ex Schum. does present wound-healing activity in rats and does not possess dermal toxicity via topical administration.