Examinando por Materia "Polypharmacy"

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Asociación entre depresión y la enfermedad de Parkinson: casos y controles en el hospital San Juan de Lurigancho, 2026
(Universidad Privada Norbert Wiener, 2026-04-20) Figueroa Merino, Milagros Margot; Chucas Ascencio, Luis Alberto
Objetivo: Determinar la asociación entre la depresión y la enfermedad de Parkinson (EP) en pacientes atendidos en el Hospital de San Juan de Lurigancho durante 2026, identificando factores sociodemográficos y clínicos asociados, calculando la prevalencia diferencial entre casos y controles, y estableciendo la magnitud de dichas asociaciones. Metodología: Estudio de método hipotético-deductivo, observacional analítico de casos y controles (n=164: 82 casos con depresión BDI-II ≥14, 82 controles BDI-II <14), con corte transversal y componente retrospectivo en población adulta con EP confirmada. Se recolectaron datos sociodemográficos (edad, sexo, etc.) y clínicos (tiempo de enfermedad, comorbilidades, polifarmacia, Hoehn-Yahr) vía ficha de recolección de datos y cuestionario BDI-II validado; el análisis incluyó pruebas bivariadas (x²), regresión logística multivariable (OR IC95% y p<0.05). Resultados principales: Se encontró una asociación estadísticamente significativa entre la depresión y la enfermedad de Parkinson (x² = 19,82, p = 0,003), con prevalencia en casos vs. controles. En el análisis bivariado, se asociaron con depresión el estado civil casado, la presencia de comorbilidades y la polifarmacia de 3 fármacos. En la regresión logística, permanecieron asociadas independientemente las comorbilidades de un trastorno (OR=0,53; IC 95%: 0,15–0,74; p=0,001), la polifarmacia de 3 fármacos (OR=0,41; IC 95%: 0,22–0,99; p=0,026) y el estado civil casado (OR=1,66; IC 95%: 0,78–3,31; p=0,015). Conclusión principal: Existe fuerte asociación entre depresión y progresión de EP, mediada por factores clínicos modificables, justificando cribado sistemático con BDI-II y optimización farmacológica para mejorar el manejo integral en contextos hospitalarios peruanos.
Acceso abierto
Consecuencias de la polifarmacia en adultos mayores con enfermedades crónicas del asentamiento humano San Benito, Lima – 2023
(Universidad Privada Norbert Wiener, 2023-09-21) Burga Linares, Lourdes Lizet; Zarate Suarez, James; Respicio López, Patricia Milagros
The present research aimed to determine the consequences of polypharmacy in older adults with chronic diseases in the San Benito Human Settlement, Lima, 2023. Methodology: Deductive method, quantitative approach, applied type, non-experimental design, sample of 120 older adults with chronic diseases and under polypharmacy, survey as a technique, and questionnaire as an instrument. Results: The most common undesired effects were gastrointestinal disorders at 60.0%; in the medication errors dimension, 33.3% of respondents reported almost always interrupting their medication and only taking it when they feel unwell; in the self-medication dimension, 51.7% self-medicate when they do not achieve the desired effect from the prescribed medication; in the healthcare costs dimension, 40.0% of respondents stated that due to a lack of medication in public hospitals, they are forced to purchase it in private establishments; and finally, in the quality of life dimension, 36.7% opined that polypharmacy prevents them from carrying out their daily tasks. Conclusion: The consequences of polypharmacy affect the physical, psychological, and economic health of the elderly population; it was evidenced that 49% of respondents experienced consequences due to polypharmacy.
Acceso abierto
Factores clínico-demográficos asociados a la enfermedad renal crónica en adultos mayores polimedicados del Hospital Nacional Arzobispo Loayza – 2025
(Universidad Privada Norbert Wiener, 2026-05-29) Barreda Gutiérrez, Karoline Alejandra; Lopez Bulnes, Jorge Luis
El presente estudio tuvo como objetivo determinar los factores clínico-demográficos asociados a la enfermedad renal crónica en adultos mayores polimedicados atendidos en el Hospital Nacional Arzobispo Loayza durante el año 2025. Se empleó un enfoque cuantitativo, tipo aplicado, diseño no experimental de corte transversal y nivel correlacional. La muestra estuvo conformada por 152 historias clínicas seleccionadas mediante muestreo no probabilístico por conveniencia. Se utilizó análisis documental con ficha estructurada, procesada en STATA v.17 mediante estadística descriptiva, Chi-cuadrado y regresión de Poisson con enlace logarítmico para estimar razones de prevalencia con IC al 95%. Los resultados evidenciaron predominio del grupo etario de 70–79 años (46.71%), sexo femenino (51.97%) y nivel educativo primario (47.37%). El 60.53% presentó síndrome metabólico y el 65.79% polifarmacia, con mayor frecuencia en estadio 3 de ERC (56.6%). En el análisis multivariado, la polifarmacia severa (RP=2.21; p=0.002), la diabetes mellitus (RP=1.76; p=0.018) y la dislipidemia (RP=1.58; p=0.043) resultaron factores independientemente asociados. Se concluye que la polifarmacia severa constituye el principal factor asociado a la ERC en esta población, seguida de la diabetes mellitus y la dislipidemia.
Acceso abierto
Factores que influyen en la depresión en pacientes geriátricos de larga estancia
(Universidad Privada Norbert Wiener, 2017-08-24) Cancio Nuñez, Virginia Estefania; Cordero Bravo, María Del Carmen; Gómez Gonzales, Walter Edgar
Objetivo: Sistematizar las evidencias sobre los factores que influyen en la depresión en pacientes geriátricos de larga estancia. Resultados: Los artículos encontrados 14 de ellos señalan que los factores que influyen en la depresión del adulto mayor son: 1.- Factor socio demográficos (sexo femenino, instrucción primaria incompleta, analfabetismo, duelo, enfermedades crónicas degenerativas, ingreso a la residencia, miedo a la muerte, trastornos neurológicos y psiquiátricos, estado civil, niveles altos de ansiedad, institucionalizados menos de 1 año), 2.- Factor Económicos: bajo ingreso económico, tipo de hogar, pobre soporte social, dependencia económico3.- Factor ABVD: dependencia funcional, sedentarismo, mujeres parcialmente dependientes, dependencia de algunas de las ABVD, polifarmacia, incontinencia urinaria, caídas, trastorno del sueño. Conclusión: Los factores socios demográficos, económicos y los de ABVD descritos en los resultados influyen en la depresión del adulto mayor. El mismo proceso de institucionalización ha sido documentado por algunos autores como desencadenante de procesos depresivos así algunos autores plantean como la institucionalización en residencias se asocian a factores que favorecen la aparición de cuadros o síntomas depresivos y que pueden dar lugar a un aumento de la prevalencia de este proceso.
Acceso abierto
Interacciones medicamentosas potenciales asociados a polifarmacia en prescripciones de pacientes de la Unidad de Cuidados Intensivos de la Clínica San Pablo, febrero–abril 2021
(Universidad Privada Norbert Wiener, 2021-10-04) Huayta Pillco, Fiorela; Torres Veliz, Ernesto Raúl
This research aimed to determine the relationship between polypharmacy and the presence of potential drug interactions by evaluating prescriptions for patients in the Intensive Care Unit of a local clinic. A descriptive, prospective, and correlational study was conducted, using a data collection form as the instrument. The Micromedex database was used to evaluate pharmacotherapy, and the Pearson's Chi-squared test and Spearman's Rho Correlation Coefficient were used for hypothesis testing. A total of 283 prescriptions were evaluated, with 51.9% containing 6 to 10 medications. The most common comorbidity was arterial hypertension (46.3%), and 57.6% of the patients were aged between 50 and 69. Regarding interaction frequency, 46.6% of prescriptions had 1 to 5 interactions, followed by 35.4% with 6 to 10 interactions. The most frequent therapeutic group involved was opioid analgesics (22.6%). The most predominant type of interaction was pharmacodynamic (66%), and 61.8% had a major severity level. Finally, it was determined that polypharmacy is significantly related to the presence of potential drug interactions.
Acceso abierto
Interacciones medicamentosas potenciales en prescripciones médicas con polifarmacia del área de Medicina Interna en los pabellones 2-I y 3-I del Hospital Nacional Arzobispo Loayza Cercado de Lima, 2021
(Universidad Privada Norbert Wiener, 2022-06-09) Ramirez Gonzales, Katherine Geraldine; Vilcapoma Peña, Henrry Ademir; Ramos Jaco, Antonio Guillermo
The objective of this research was to determine the characteristics of potential drug-drug interactions (PDDIs) in medical prescriptions with polypharmacy in the internal medicine area (wards 2-I and 3-I) of the Arzobispo Loayza National Hospital. The study was descriptive, cross-sectional, with a quantitative approach, and was conducted from November to December 2021. A total of 220 medical prescriptions were analyzed using the UpToDate and Drugs.com databases to identify potential PDDIs. A total of 1,270 PDDIs were found and characterized. The interactions were pharmacodynamic (78.27%) and pharmacokinetic (21.63%). By severity, 10.31% were minor, 74.65% were moderate, 15.04% were major, and none were contraindicated. The most frequent medication combinations were dimenhydrinate/tramadol (32) and enoxaparin/losartan (32). The most frequent therapeutic groups were cardiovascular medications (18.3%) and gastrointestinal medications (14.3%). In conclusion, 95.5% of medical prescriptions with polypharmacy presented potential drug-drug interactions.
Acceso abierto
Interacciones medicamentosas relacionadas a la polifarmacia psiquiátrica en usuarios adultos del Instituto Nacional de Salud Mental de Lima 2021
(Universidad Privada Norbert Wiener, 2022-10-07) Oropeza Garay, Shulen Liuva; Guerrero García, Esther Doris; Alvarado Chávez, Britt
Objective: "To determine the relationship between psychiatric polypharmacy and drug interactions in adult users of the National Institute of Mental Health in Lima, 2021." Method: Deductive with a quantitative approach, basic study, non-experimental, descriptive, correlational, retrospective, and cross-sectional. The technique used was observation, and the instrument was a data collection form. Results: The study evaluated 300 medical prescriptions. Of the patients, 51% were aged 18 to 39 years, and 40% were aged 40 to 59 years; 56% were male, and 44% female. Regarding the number of psychotropic drugs prescribed, 86% were prescribed 4 to 5 psychotropic drugs, and 11% were prescribed between 6 and 7. Additionally, 42.3% had indications every 12 hours, and 57.3% had treatments lasting 1 to 2 months. The most prevalent type of polypharmacy was adjuvant polypharmacy (72.7%), followed by total polypharmacy (10.3%) and multiclass polypharmacy (7.7%). The most frequent therapeutic groups were antidepressants (37.7%) and antipsychotics (33.7%). Regarding drug interactions, 51% had 1 to 3 interactions, 35% had 4 to 6 interactions, and 3.3% had more than 10 interactions. Of these, 52.3% were synergistic drug interactions, and 45.7% were pharmacokinetic interactions affecting metabolism. Severe drug interactions were observed in 81% of cases, while 18% were moderate. Regarding documentation, 75.7% presented suspicious or fair evidence, while 12.7% had probable or good evidence. Conclusion: It was determined that there is a significant relationship between psychiatric polypharmacy and drug interactions in adult users of the National Institute of Mental Health in Lima, 2021.
Acceso abierto
Patologías hepáticas y su relación con la polifarmacia en adultos mayores que se atienden en una clínica privada de Surco, 2022
(Universidad Privada Norbert Wiener, 2023-02-16) Isidro Duran, Marlene; Rosales Santivañez, Mida Eusebia; Oyarce Alvarado, Elmer
The objective of this research was to determine the relationship between polypharmacy and liver pathologies in older adults treated at a private clinic in Surco in 2022. Methodology: A quantitative approach was used with a correlational and retrospective design. A sample of 141 medical records of patients over 60 years of age was collected. The results obtained through statistical tests (Chi-square, Phi, and Cramer’s V) demonstrated a strong correlation between polypharmacy and liver pathologies in older adults at the private clinic in Surco. Therefore, it is concluded that polypharmacy is significantly related to liver pathologies in these patients. Furthermore, it is important to highlight that the simultaneous treatment of multiple pathologies with the use of medications in older adults often results in negative side effects on certain organs. For this reason, proper care and supervision by healthcare professionals are necessary to prevent potential health problems related to polypharmacy in these patients. The results of this research are relevant for improving medical care and preventing health issues associated with polypharmacy in older adults.
Acceso abierto
Polifarmacia con relación al tratamiento de las infecciones respiratorias agudas en adultos mayores que acuden a la Botica Kerofarma. Distrito de Bellavista, Callao, Perú. Agosto-diciembre, 2023
(Universidad Privada Norbert Wiener, 2025-01-15) Bautista Chancos, Yessica; Sanchez Davila, Florile; Parreño Tipián, Juan Manuel
The objective was to identify the relationship between polypharmacy with the treatment of acute respiratory infections in older adults who go to the Kerofarma pharmacy in the Bellavista Callao district, Peru. August-December 2023. Methods: The study had a quantitative approach, cross sectional, non-experimental design, descriptive correlational scope, basic type, hypothetical deductive method, sample: 183 older adults, the data were collected through a survey with the use of a questionnaire, the hypothesis was tested using Chi square analysis. Results: Demographic data: 49.7% were between 60-65 years old; Regarding polypharmacy due to adverse reactions, 60.7% presented itching or skin rash, 67.2% had burning and/or stomach pain; sleep disturbances 63.3%; In self-medication, 68.3% were on their own initiative; In medication errors, 68.9% used medications only when they felt bad. In pharmacological treatment they used: beta-lactams 33.9%; macrolides 15.8%; sulfamethoxazole and trimethoprim 19.1%; ibuprofen 30.1%; metamizole 16.4%; paracetamol 19.1%; diclofenac 38.3%; prednisone 21.9%; dexamethasone 44.3%; ambroxol 26.2%; dextromethorphan 30.1%; chlorphenamine 32.8%; cetirizine 37.2%; salbutamol 25.1%; clenbuterol 30.1%. 12.6% consumed between 5 to 6 medications; between 3-4 medications 4.4% and between 7-9 medications 2.7%. There was no significant difference between polypharmacy with the treatment of acute respiratory infections in older adults (p>0.05). Conclusion: There is no relationship between polypharmacy and the treatment of respiratory infections, since if polypharmacy increases it could increase adverse reactions, self-medication, medication errors, consequences in daily activities and reduce the effectiveness of the treatment of infections. acute respiratory.
Acceso abierto
Polifarmacia e interacciones farmacológicas en adultos mayores atendidos en el departamento de medicina del Hospital Militar Central Coronel Arias Schreiber, Lima 2024
(Universidad Privada Norbert Wiener, 2025-06-02) Arce Tarazona, Soreli Soledad; Cabanillas Mejía, Jesús José; Muñoz Jáuregui, Manuel Jesús
The present work had the objective: "To determine the relationship between polypharmacy and drug-drug interactions in older adults treated in the Department of Medicine of the Coronel Arias Schreiber Central Military Hospital, Lima 2024". Being the methodology, this basic research was based on the quantitative approach and the hypothetical-deductive method. Its methodological design corresponded to a non-experimental and retrospective study with cross-sectional and correlational level, the population object of analysis consisted of 130 Pharmacotherapeutic Monitoring Forms. To obtain the results, the Cramer's V statistical test was used, obtaining the following: It shows that there are a greater number of pharmacotherapeutic monitoring forms with patients in the age range of 60 to 70 years (36.9%) and that the most present sex was male with 71.5%. Regarding polypharmacy, more patients were found to have excessive polypharmacy, at 74.6%. On the other hand, regarding the drug-drug interactions dimension based on severity, the highest severity was found, at 71.5%. Regarding the level of documentation dimension, the moderate level was most prevalent, at 76.9%. In the interaction mechanism dimension, pharmacodynamic interactions were more common in older adults than pharmacokinetic interactions (54.6% vs. 45.4%). Regarding hypothesis testing, the relationship and high intensity of the association between the polypharmacy variable and the drug-drug interactions variable were confirmed, with a p-value of 0.000 < 0.05 and a Cramer's V value of 0.776 (greater than 1). It was concluded that there was a correlation between polypharmacy and drug-drug interactions in older adults.
Acceso abierto
Polifarmacia riesgo de la medicación en el adulto mayor
(Universidad Privada Norbert Wiener, 2018-11-04) Sanchez Chipana, Maria Carolina; Torres Avalos, Edith; Calsin Pacompia, Wilmer
Objetivo: Analizar y sistematizarlas evidencias sobre la polifarmacia es el mayor riesgo de la medicación en el adulto mayor. Material y Métodos: Las revisiones sistemáticas son una forma de investigación que recopila y proporciona un resumen sobre un tema específico (orientado a responder a una pregunta de investigación); se deben realizar de acuerdo a un diseño preestablecido. Es una Revisión sistemática de 10 artículos seleccionados, mediante la base de datos Pubmed, Open Access, Researchgate, Wiley Online Lybrary, Online Library, Scielo, Epistemonikos y EBSCO. Los 10 artículos seleccionado son investigaciones cuantitativas, 40% (4) son revisión sistemática, 30% (3) son de cohorte, 20% (2) caso control y 10%(1) es transversal. Resultados: En esta revisión sistemática, según las evidencias encontradas se concluye que el mayor riesgo de la medicación en el adulto mayor es la polifarmacia que representa el 100% (16 - 25), seguida de la edad el 80% (17 -24), el género 50% (19 - 23), luego son los trastornos psiquiátricos, las comorbilidades, la situación funcional, cognición y el uso de medidas no farmacológicas. Conclusión: La polifarmacia es el mayor riesgo de la medicación en el adulto mayor, seguida de la edad, el género, los trastornos psiquiátricos, las comorbilidades, la situación funcional, cognición y el uso de medidas no farmacológicas.
Acceso abierto
Polifarmacia y adherencia terapéutica en paciente adulto mayor con hipertensión arterial atendidos en el Hospital de Ventanilla Callao- 2024
(Universidad Privada Norbert Wiener, 2025-09-16) Quinteros Pizarro, Milena Soledad; Yerren Acosta, Elizabeth Veronica; Parreño Tipián, Juan Manuel
As a general objective, this research considered determining the relationship between polypharmacy and therapeutic adherence in older adults with arterial hypertension treated at the Ventanilla – Callao hospital in 2024. In relation to its methodology, it revealed a hypothetical deductive method with a quantitative and basic approach. It had a non-experimental-cross sectional design with a correlational scope. The instrument was a questionnaire with 10 multiple choice questions and an 8 item Morisky-Green test. A survey was applied as a technique, while the sample was composed of 217 older adults. The results showed a high and significant positive correlation between polypharmacy and therapeutic adherence Rho 0.861, as well as with the behavioral Rho 0.803, cognitive Rho 0.807, and psychological Rho 0.811 dimensions. A moderate positive association was also found for polypharmacy and contextual barriers Rho 0.750. lastly, the relationship was high and positive for the number of medications, safety, and relevance of the medication with said adherence Rho 0.866. The conclusion stated that, in older adults, high polypharmacy leads to low therapeutic adherence, by virtue of the fact that, as the quantity of medication intake increases, the probability of the not correctly following their medical prescription is greater. Therefore, this polypharmacy is causing these older adults to have adverse reaction, medication exchanges, and even complications with their memory and ability to understand, hindering the respective adherence.
Acceso abierto
Polifarmacia y calidad de vida en adultos de la tercera edad en el grupo 18 y 19 del primer sector del distrito de Villa el Salvador – Lima Metropolitana, 2021–2022
(Universidad Privada Norbert Wiener, 2022-07-09) Aguilar Chávez, Ronald Javier; Candela Rodríguez, Cecilia Lorena; León Apac, Gabriel Enrique
The objective of this report was to identify the relationship between polypharmacy and quality of life in older adults in groups 18 and 19 of the first sector of the Villa el Salvador district, Metropolitan Lima, from 2021 to 2022. Method: A quantitative approach was used, with a basic type, a non-experimental design, and a correlational level. A sample of 280 adults over 60 years old who consumed more than three medications was obtained. A questionnaire with questions about polypharmacy and quality of life was administered via a survey. SPSS Version 25.0 was used for statistical analysis, and the Chi-squared test of independence was performed at a 5% significance level. Result: Regarding the general hypothesis, it was observed that polypharmacy is related to quality of life because the p-value is less than 0.05 (p=0.000). Conclusion: It was established that a relationship exists between polypharmacy and quality of life in older adults in groups 18 and 19 of the first sector of the Villa el Salvador district, Metropolitan Lima, from 2021 to 2022.
Acceso abierto
Polifarmacia y calidad de vida en adultos mayores con enfermedades cardiovasculares atendidos en la botica Familia y Salud, San Juan de Miraflores, Lima 2025
(Universidad Privada Norbert Wiener, 2025-11-19) Andía Quispe, Julia; Andamayo de Castillo, Diana Esmeralda
Polypharmacy is common in older adults with cardiovascular comorbidities and is associated with adverse reactions, hospitalizations, and impaired quality of life. In Peru, self-medication, fragmented access to medications, and poor coordination between healthcare levels exacerbate this problem, especially in populous districts such as San Juan de Miraflores. Objective: To determine the relationship between polypharmacy and quality of life in older adults with cardiovascular diseases treated at the aforementioned pharmacy. Materials and methods: A quantitative, basic, non-experimental, cross-sectional, and correlational study was conducted in 81 adults aged ≥60 years. An ad hoc polypharmacy questionnaire and the SF-12 were administered. Descriptive analyses and association tests (χ², ANOVA) were performed, with a significance level of 0.05. Results: A total of 40.7% of participants presented polypharmacy. Quality of life was mostly low (49.4%) or below average (44.4%). A statistically significant inverse relationship was demonstrated between the number of medications taken and quality of life (p=10.079; p=0.039). Conclusion: It is concluded that polypharmacy had a negative and multifactorial impact on the well-being of the population studied, mediated by adverse effects and a deterioration in daily functioning.
Acceso abierto
Polifarmacia y Calidad de vida en usuarios adultos mayores de boticas del Cercado de Lima, Lima 2023
(Universidad Privada Norbert Wiener, 2024-07-12) Mescua Villalva, Yanela Beatriz; Pope Guido, Catherine Stephany; Caldas Herrera, Emma
The objective of this study was to evaluate the relationship between polypharmacy and quality of life in elderly users of pharmacies in Cercado de Lima, Lima, 2023. A hypothetical-deductive, quantitative, applied, non-experimental, correlational study was conducted using a questionnaire administered to 286 elderly adults selected through systematic probabilistic sampling. For statistical analysis, SPSS version 25.0 was used, and the chi-square test of independence was employed at a significance level of 5% to test the hypotheses. The results indicate that polypharmacy was present in 66.1% of the sample, and quality of life was fair in 52.1%. Polypharmacy was found to be related to quality of life, with a p-value less than 0.05." (p=0.000); likewise, a relationship was found between polypharmacy and quality of life at the level of the Physical Component (p=0.000) and the Mental Component (p=0.000). It is concluded that there is a significant relationship between polypharmacy and quality of life in elderly users of pharmacies in Cercado de Lima, Lima 2023.
Acceso abierto
Polifarmacia y factores asociados en el tratamiento de la COVID-19 en adultos de la Urbanización San Germán-La Victoria-Lima-2022
(Universidad Privada Norbert Wiener, 2023-02-02) Lipa Chavez, Nahayomi Solange; Mendoza Salcedo, Rildo Romario; Rojas Wisa, Oscar Favio
The objective of this study is to determine the relationship between polypharmacy and associated factors in the treatment of COVID-19 in adults from the San Germán Urbanization - La Victoria - Lima. Method: A quantitative approach, basic type, non-experimental design, and correlational level were used. The sample consisted of 293 citizens aged 25 to 44 years. Data collection was carried out using the survey technique, and statistical analysis was performed with SPSS Version 25.0 and the Spearman Correlation Coefficient, indicating the feasibility of continuing the research work. Result: Polypharmacy is related to the associated factors since the p-value is less than 0.05 (p-value = 0.000). Conclusion: The relationship between polypharmacy and associated factors in the treatment of COVID-19 in adults from the San Germán Urbanization - La Victoria - Lima - 2022 was determined.
Acceso abierto
Polifarmacia y riesgo de caídas en adultos mayores atendidos en un centro de rehabilitación de Lima 2025
(Universidad Privada Norbert Wiener, 2026-04-20) Quispe Lipa, Silvia; Sifuentes Pérez, Megaly; Arrieta Córdova, Andy Freud
Introducción: Las caídas en personas mayores constituyen un problema de salud pública por su frecuencia, consecuencias funcionales y costos. En rehabilitación, la estratificación del riesgo mediante desempeño de equilibrio–marcha es clave; sin embargo, la contribución de la polifarmacia a dicho riesgo en servicios locales de Lima no ha sido cuantificada. Objetivo: Determinar la relación entre la polifarmacia y el riesgo de caídas en adultos mayores atendidos en un centro de rehabilitación de Lima. Material y métodos: Estudio aplicado, observacional, correlacional de corte transversal. Se realizó un censo de 125 adultos ≥60 años. La polifarmacia se definió por el registro total de fármacos prescritos o de venta libre usados en los últimos 7 - 14 días, dicotomizada en sí (≥5) / no (<5). El riesgo de caídas se estimó con la escala Tinetti/POMA (total 0–28: <18 alto, 19–23 moderado, ≥24 bajo) y subescalas con clasificación binaria (Equilibrio <10/16 = déficit; Marcha <9/12 = déficit). Se recolecto variables sociodemográficas y clínicas. Se realizo análisis descriptivos y bivariados (chicuadrado/Fisher). Resultados: Se identificó una asociación significativa entre la polifarmacia y la dimensión marcha (x² = 54,192; p = 0,000). Este resultado indicó que el nivel de polifarmacia estuvo relacionado con la presencia o ausencia de alteración en la marcha de los adultos mayores evaluados. Conclusión: Existió asociación significativa entre la polifarmacia y la dimensión marcha del riesgo de caídas en adultos mayores.
Acceso abierto
Polimedicación y adherencia al tratamiento antihipertensivo en adultos mayores que acuden al centro de atención primaria III San Isidro, Lima 2025
(Universidad Privada Norbert Wiener, 2025-08-14) Yuyali Sulca, Jorge Luis; Collantes Llacza, Adela Marlene
Objective: This investigation fulfills the objective of determining the relationship of polypharmacy with adherence to antihypertensive treatment in older adults who attend San Isidro´s primary care center III. Methodology: A questionnaire is used to evaluate polypharmacy and the test "the Adherence in Chronic Diseases Scale" (ACDS) to measure adherence that were applied to a sample of 331 patients from the Primary Care Center III San Isidro, Lima, with the objective of obtaining results through a non-experimental design of a descriptive correlational type. Results: It was found that there is a significant inverse relationship between polypharmacy and adherence to antihypertensive treatment with a p value of 0.000. Regarding the specific objectives, it was found that there is a significant inverse relationship between; Polypharmacy and adherence to the dosage regimen, polypharmacy and self-adjustment of medication dose, both with a p value of 0.000, polypharmacy and patient attitude with a p value of 0.002, and between polypharmacy and physician-patient communication with a p value of 0.017. Conclusions: There is a significant inverse relationship between polypharmacy and adherence to antihypertensive treatment (p = 0.000 < 0.050; r = - 0.280) in older adults attending the San Isidro Primary Care Center III, Lima.
Acceso abierto
Relación entre polifarmacia y reacciones adversas medicamentosas en pacientes hospitalizados en el servicio de cirugía de tórax, corazón y vascular periférica, del Hospital Edgardo Rebagliati Martins–EsSalud en el periodo de marzo–mayo de 2013
(Universidad Privada Norbert Wiener, 2014) Luis Ricra, Luz Marlene; Torres Veliz, Ernesto Raúl
This study monitored adverse drug reactions (ADRs) in hospitalized patients from the Thoracic, Cardiac, and Peripheral Vascular Surgery Service at Hospital Edgardo Rebagliati Martins–EsSalud between March and May 2013. It was designed as an observational, cross-sectional, descriptive, and prospective study, including 127 patients. The objectives were to examine the relationship between polypharmacy and ADRs, to identify ADRs according to sex and age, and to determine the pharmacological groups and specific drugs most frequently involved. ADRs were classified according to severity and the affected organ system, and causality was assessed. The results indicated that men between 56 and 74 years were the most affected. The pharmacological groups most frequently associated with ADRs were nitrates, statins, loop diuretics, and NSAIDs, with the most implicated drugs being isosorbide, atorvastatin, furosemide, metamizole, diclofenac, and paracetamol. Moderate reactions were predominant, and the majority of ADRs were classified as probable according to causality assessment. The most affected organ systems were cardiovascular and gastrointestinal, with additional metabolic disorders observed. In conclusion, ADRs were more common in older male patients receiving multiple medications, underscoring the need for pharmacovigilance and preventive strategies in surgical hospital services.