Examinando por Materia "Pomegranate"

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Acceso abierto
Anti-inflammatory effect of Funica Granatum L. in patients with cardiovascular disease
(Universidad Privada Norbert Wiener, 2021-12-20) Marca Lizama, Silvia Lucía; Bohórquez Medina, Sofia Lorena
Over the last few years, researchers have been studying certain phytochemicals present in different foods and their beneficial effect on people's health; polyphenols being one of the most investigated types of phytochemicals. The “Punica granatum” pomegranate has polyphenols such as: ellagic acid, punicalagin, among the most important; They have been studied in different non-communicable conical diseases such as cardiovascular diseases and cancer. In the present secondary research titled as Critical Review: Anti-inflammatory effect of Punica granatum in patients with cardiovascular disease; whose objective was to know the effect of pomegranate consumption on pro-inflammatory biomarkers, serum lipid levels and blood pressure levels. The clinical question was: Would the consumption of pomegranate (Punica Granatum L.) or its bioactive components produce anti-inflammatory effects in patients with cardiovascular disease? The evidence-based nutrition (NuBE) methodology was used. The search of the scientific literature was carried out in Spanish and English. The databases consulted were SCOPUS, WOS, PUBMED/MEDLINE AND EMBASED. 28 articles were found and 9 were selected, for which the CASPe tool was used. The selected study was “The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: A meta-analysis and systematic review”. The critical commentary revealed that the consumption of substances derived from pomegranate could help reduce inflammatory biomarkers, as well as serum lipid levels and blood pressure. Future studies are necessary to establish a recommended dose, as a complementary aid to pharmacological treatment.
Acceso abierto
Revisión crítica: efecto de la suplementación con granada (punica granatum) en los marcadores metabólicos de pacientes con enfermedad hepática esteatósica asociada a disfunción metabólica
(Universidad Privada Norbert Wiener, 2025-11-13) Chambi Quispe, Liz Vanessa; Bohórquez Medina, Andrea Lisbet
La enfermedad hepática esteatósica asociada a disfunción metabólica (MASLD) constituye un desafío sanitario global para el cual no existe un tratamiento farmacológico estándar, impulsando la exploración de alternativas nutracéuticas. Esta revisión crítica evaluó, mediante metodología de Nutrición Basada en la Evidencia (NuBE), el efecto de la suplementación con granada rica en punicalaginas y antocianinas, sobre los parámetros metabólicos en pacientes con enfermedad hepática esteatósica asociada a disfunción metabólica. Tras una búsqueda sistemática en múltiples bases de datos, que arrojó 1098 artículos, se seleccionaron 10 estudios para su evaluación crítica con la herramienta CASPe. El análisis identificó que un ensayo clínico aleatorizado y doble ciego, con nivel de evidencia BI y Grado de Recomendación FUERTE, demostró que el extracto de cáscara de granada mejora factores de riesgo del síndrome metabólico. En conclusión, la suplementación exhibe un potencial hepatoprotector y una significativa reducción de la rigidez hepática, atribuidos principalmente a su potente capacidad antioxidante y antiinflamatoria. Sin embargo, la evidencia actual es insuficiente para recomendarla como terapia única, siendo necesarios estudios de mayor duración y poder estadístico para definir su rol en el manejo clínico de la MASLD.