Examinando por Materia "Proteína C-Reactiva"

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Acute phase protein alterations in patients with a diagnosis of covid-19 in a polyclinic in Lima, 2020
(Universidad Privada Norbert Wiener, 2023-09-24) Oliva Colan, Ana Rosa; Ascarza Gallegos, Justo Angelo
COVID-19 is a viral disease caused by SARS-CoV-2, which is distributed worldwide and causes high mortality and morbidity rates due to the acute inflammatory processes it induces. This study aims to determine the alterations of acute phase proteins in patients diagnosed with COVID-19 at a polyclinic in Lima, Peru, from April to September 2020. A descriptive cross-sectional study was conducted with 1,393 results, and a sample of 473 patients from the ROAL Polyclinic in Los Olivos district was analyzed. Serum concentrations of COVID-19 patients were evaluated using IgG, IgM, or both rapid tests. The analyzed acute phase proteins included C-reactive protein (CRP), lactate dehydrogenase (LDH), cortisol, and D-dimer. Data analysis and the construction of figures and tables were done using STATA v14.0, with statistical descriptive analysis for estimating frequencies and central tendency measures.
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C-Reactive Protein and Its Relationship with Risk Factors Associated with Metabolic Syndrome in Maintenance Workers Assisted for an Occupational Health Evaluation in 2016
(Universidad Privada Norbert Wiener, 2017-11-10) Vásquez Mosanapón, Juana Iris; Benites Azabache, Juan Carlos
Objective: To establish the relationship between C-reactive protein (CRP) levels and risk factors associated with metabolic syndrome in maintenance workers undergoing Occupational Health assessments in 2016. The study type was quantitative, prospective, cross-sectional, descriptive. Maintenance workers who underwent annual health checks at an occupational health laboratory in 2016 were tested for glucose, HDL cholesterol, triglycerides, and measurements of waist circumference and blood pressure. These results were compared with CRP levels. Regarding the Spearman correlations between CRP and factors associated with metabolic syndrome, a correlation coefficient of 0.190 was observed with a significance of 0.086, indicating no significant relationship with CRP. However, a significant relationship was found between glucose and CRP in this population, with a correlation coefficient of 0.291 and a significance of 0.008. Among the metabolic syndrome factors compared with CRP, glucose was found to have a significant relationship with a correlation coefficient of 0.291 and significance of 0.008.
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Correlation between leukocytes and protein C, reactive in patients hospitalized for Covid-19 at Hospital San José 2020
(Universidad Privada Norbert Wiener, 2022-06-04) Rios Franco, Syntia; Huamán Cárdenas, Victor Raul
The COVID-19 pandemic has affected millions of people and caused hundreds of thousands of deaths worldwide. Pneumonia and severe hypoxemia associated with severe acute respiratory syndrome caused by coronavirus infection (SARS-CoV-2) can lead to acute respiratory distress syndrome (ARDS), which is associated with a high mortality rate. Severe acute respiratory syndrome clinical examinations found leukocytosis with the severity of infection, such as C-reactive protein. Laboratory findings show a positive relationship between the increase in C-reactive protein and leukocytes, which may relate to the severity of the inflammatory condition. Therefore, this project aims to determine the relationship between leukocytes and C-reactive protein. In this study, clinical records were used, meeting the inclusion and exclusion criteria. The method used will be a hypothetical-deductive approach with a quantitative, applied, correlational, cross-sectional, and retrospective design, utilizing SPSS tools, with results indicating a positive correlation between leukocyte levels and C-reactive protein.
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Design of procalcitonin versus markers used for the diagnosis of bacterial sepsis in patients at the Intensive Care Unit of the National Hospital Alberto Sabogal Sologuren, 2015
(Universidad Privada Norbert Wiener, 1905-07-07) Gonzales Vasquez, Jose Marino; Hilario Velasquez, Flor Eduvines; Baltodano Honores, Carlos Alberto
Introduction: Diagnosing sepsis in the Intensive Care Unit remains a major challenge, as it can lead to death due to multiple organ failure. Procalcitonin is a marker used to differentiate bacterial infections from inflammatory processes of other etiologies. The aim of this study was to determine the performance of procalcitonin compared to other markers used to diagnose bacterial sepsis in the Intensive Care Unit of the National Alberto Sabogal Sologuren Hospital in 2015. Methodology: The study was descriptive, comparative, non-experimental, prospective, and cross-sectional. Results: 30 patients from the Intensive Care Unit of the National Alberto Sabogal Sologuren Hospital, with a presumptive diagnosis of sepsis, were studied from January to April 2015. Of these, 26.67% had a positive blood culture, considered the confirmatory test for bacterial sepsis. The performance of the tests was as follows: Procalcitonin (PCT): Sensitivity (S) 87.5%, Specificity (E) 95.45%, Positive Predictive Value (PPV) 87.5%, Negative Predictive Value (NPV) 95.4%. For C-reactive protein (CRP): S 100%, E 0%, PPV 26%, NPV 0%. For the Erythrocyte Sedimentation Rate (ESR): S 100%, E 4.76%, PPV 27.58%, NPV 100%. For white blood cell count: S 75%, E 50%, PPV 35.2%, NPV 84.6%. For neutrophil percentage: S 100%, E 15.78%, PPV 29.63%, NPV 100%. Conclusion: Procalcitonin showed better performance for diagnosing bacterial sepsis compared to other markers used currently in the hospital.
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Relación entre PCR y ferritina en pacientes con eritrocitosis patológica de altura evaluados en la Clínica Ortega, 2022
(Universidad Privada Norbert Wiener, 2025-02-23) Contreras Romero, Monica Marianela; Cossio Villar, Mery Ann
La Eritrocitosis es un tipo de Policitemia donde aumentan los glóbulos rojos como también la hemoglobina, la ferritina es una proteína celular que almacena hierro y permite al organismo utilizar cuando este lo requiera, la Proteína C Reactiva es producida por el hígado y es un indicador de procesos inflamatorios, el objetivo de este estudio es evaluar el tipo de relación que existe entre PCR y la Ferritina en pacientes con eritrocitosis patológica de altura evaluados en la clínica Ortega 2022, en este estudio se recolectaran datos de las historias clínicas de pacientes con EPA de edad comprendidas entre 18 y 90 años durante el año 2022 llevando a cabo un método hipotético-deductivo con un enfoque cuantitativo siendo la investigación de tipo básica o pura.
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Relationship between ferritin and c-reactive protein in children with iron deficiency anemia at the Manchay health center, 2019
(Universidad Privada Norbert Wiener, 2023-06-25) Collantes Rabanal, Delia Bernardita; Suca Cueto, César Eusebio; Borja Velezmoro, Gustavo Adolfo
This research aimed to determine the relationship between ferritin and C-reactive protein in children with iron deficiency anemia, using a deductive-quantitative methodology of a non-experimental type, with observation and documentary analysis techniques. The study was based on 409 results and used Spearman's rho test to determine the relationship between ferritin and C-reactive protein, finding a high positive and statistically significant correlation between both. The male sex (52.8%) had a higher prevalence, and the most affected ages were 2 years (39.1%) and 4 years (33.7%) in females. Both sexes predominantly had mild anemia (74.8%). The study concluded that there is a relationship between ferritin and C-reactive protein, with sex, age, and anemia level not affecting the relationship, making these ideal indicators for the specific diagnosis of iron deficiency anemia.
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Rendimiento diagnóstico de la proteína c reactiva para sepsis neonatal temprana en neonatos del Hospital Luis Heysen Inchaustegui – Chiclayo 2023
(Universidad Privada Norbert Wiener, 2025-08-09) Moreno Chinchay, Natalin Lizbeth; Lopez Bulnes, Jorge Luis
La investigación tuvo como objetivo determinar el rendimiento diagnóstico de la Proteína C Reactiva (PCR) para Sepsis Neonatal Temprana en neonatos del Hospital Luis Heysen Inchaustegui durante el 2023. La metodología utilizada fue de método analítico, enfoque cuantitativo y diseño transversal. La muestra estuvo conformada por 173 neonatos con diagnóstico definitivo de sepsis neonatal temprana descrita en la epicrisis de la historia clínica electrónica y 126 neonatos sanos. Se empleó una técnica de análisis documental por medio de una ficha de recolección de datos, para posterior a ello ser analizados en el programa estadístico RStudio, se crearon gráficos ROC y se calculó el área bajo la curva, utilizando además la prueba de Chi cuadrado y la prueba de la suma de rangos de Wilcoxon y el índice de Youden; considerando significativo un p<0.05. Como resultados, se demostró que la PCR tuvo un buen rendimiento diagnóstico con una sensibilidad del 73% y especificidad de 92.5%, VPP de 87.6% y VPN de 82.5%, hallando además como punto de corte óptimo un PCR ≥0.65 mg/dl con un AUC de 0.828. En relación al sexo se evidenció sensibilidad mayor en varones (83.6 % vs. 58.5%), y una especificidad ligeramente superior en mujeres (93% vs. 91%). En conclusión, la Proteína C Reactiva demostró ser un biomarcador con un buen rendimiento diagnóstico para sepsis neonatal temprana.
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Validity and safety of the results of the qualitative method of serum C-reactive protein, in patients treated in a particular clinic in Lima, 2018
(Universidad Privada Norbert Wiener, 2020-06-16) Meneses Lazón, Alejandro Santiago; Torres Lara, Angel Adolfo; Sandoval Vegas, Miguel Hernán
The most commonly used acute-phase infection or inflammation indicator is C-reactive protein. The most common technique for determining this indicator is the Latex method. The objective of this study was to determine the levels of validity and safety for this test by evaluating the values of these indicators (validity and safety) in a sample of 129 patients treated in a private clinic in Lima in 2018, through a quantitative, descriptive, cross-sectional, and retrospective study. The results for these indicators were evaluated in comparison with C-reactive protein results by turbidimetry to subsequently determine the Sensitivity and Specificity values for validity and Positive and Negative Predictive Values for safety. The results found sensitivity between 61% and 100%, specificity of 100%, a positive predictive value of 100%, and a negative predictive value ranging between 82% and 100%. It was concluded that the results of the qualitative C-reactive protein test are valid and safe.