Examinando por Materia "Rasgo Drepanocítico"

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Hierro sérico y capacidad total de fijación de hierro en una población de niños portadores de drepanocitosis en el distrito del Carmen – Chincha, 2019
(Universidad Privada Norbert Wiener, 2019-06-24) Martínez Pino, Wendi Patricia; Sanchez Torres, Yhojana Vanessa; Parreño Tipián, Juan Manuel
Individuals carrying sickle cell disease or the sickle cell trait (HbAS) are apparently healthy persons who have inherited only one mutant gene from one parent and can transmit it to subsequent generations. Objective: To evaluate serum iron and total iron-binding capacity in a population of children carrying the sickle cell trait in the district of El Carmen–Chincha, 2019. Methods: This is a descriptive, cross-sectional, and prospective study. The sample included 209 Afro-Peruvian schoolchildren of both sexes, aged 3–12 years. Participants were randomly selected. Informed consent was obtained from parents or legal guardians, and venous blood samples were collected. A data collection instrument was designed and applied to the population. Hemoglobin electrophoresis was used to determine sickle cell status, the Ferrozine method for serum iron, and a direct colorimetric method for total iron-binding capacity. Results: The proportion of children carrying the sickle cell trait was 5.7%. Seven positive cases were observed in the 9–12 years age group, representing the highest percentage, with six females and six males. The mean values for serum iron and total iron-binding capacity were 34.93 µg/dL and 334.44 µg/dL, respectively. Conclusion: The proportion of children with the sickle cell trait was relatively low compared to the total population and was not associated with age or sex. Serum iron and total iron-binding capacity values were within normal standards.