Examinando por Materia "Razón normalizada internacional"

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    Systematic Review on the Influence of Grapefruit Juice on the International Normalized Ratio (INR) in Anticoagulated Patients
    (Universidad Privada Norbert Wiener, 2017-12-20) Vargas Machuca Vera, Luis Enrique; Melgarejo Gonzales, Marycarmen; Benites Azabache, Juan Carlos
    The objective was to establish the influence of grapefruit juice on the international normalized ratio (INR) values in patients using oral anticoagulants. For the systematic review, searches were conducted in PUBMED, LILACS, ESSALUD VIRTUAL LIBRARY, and TRIPDATABASE, which evaluate the influence of grapefruit juice on INR values in patients with oral anticoagulants. A search strategy was developed using keywords, Boolean operators, truncations, among others. Fifteen original articles were found based on the inclusion criteria and risk of bias, with more than 60% adherence to the checklist developed by CASPe. Two articles were selected to carry out the systematic review. In conclusion, grapefruit juice consumption during anticoagulant treatment increases INR values, as it inhibits CYP3A4, altering the metabolism of anticoagulants, although the true clinical effect is often debated. Proper controlled studies are needed to fully determine whether a causal relationship exists.