Examinando por Materia "Serum Albumin, Human"

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Acceso abierto
Effectiveness of albumin treatment versus other fluids in patients with sepsis
(Universidad Privada Norbert Wiener, 2018-07-08) Benito Castro, Elizabeth Maria; Norabuena Granda, Marina Alejandra; Calsin Pacompia, Wilmer
Objective: To analyze and systematize the evidence on the effectiveness of albumin treatment versus other fluids in patients with sepsis. Materials and Methods: The design is a systematic review, using the GRADE system. The search was conducted in the following databases: Cochrane, Web of Science, OvidSP, PubMed, clinicaltrials.gov, controlled-trials.com, Medline, Elsevier, Web of Science, Embase. The population consisted of 10 articles, including systematic reviews and study samples. Four studies are clinical trials, three are systematic reviews and meta-analyses, and three are meta-analyses only. Results: Of all the studies, 60% demonstrate the effectiveness of albumin as an intravascular volume expander, decreasing the risk of renal failure, pulmonary edema levels, and significantly reducing extravascular pulmonary water. 30% demonstrate the effectiveness of other fluids as the first line in fluid resuscitation due to their market accessibility. 10% demonstrate the effectiveness of both albumin and other fluids in increasing left ventricular stroke work and systolic volume. Conclusions: Of the 10 articles, 6 demonstrate the effectiveness of albumin in patients with sepsis by reducing mortality rates, 3 demonstrate that other fluids are more effective than albumin because it showed no change in mortality, and 1 demonstrates that both albumin and other fluids are effective in increasing cardiac index.
Acceso abierto
Effectiveness of albumin treatment versus other fluids in patients with sepsis
(Universidad Privada Norbert Wiener, 2018-07-08) Benito Castro, Elizabeth Maria; Norabuena Granda, Marina Alejandra; Calsin Pacompia, Wilmer
Objective: To analyze and systematize the evidence on the effectiveness of albumin treatment versus other fluids in patients with sepsis. Materials and Methods: The design is a systematic review, using the GRADE system. The search was conducted in the following databases: Cochrane, Web of Science, OvidSP, PubMed, clinicaltrials.gov, controlled-trials.com, Medline, Elsevier, Web of Science, Embase. The population consisted of 10 articles, including systematic reviews and study samples. Four studies are clinical trials, three are systematic reviews and meta-analyses, and three are meta-analyses only. Results: Of all the studies, 60% demonstrate the effectiveness of albumin as an intravascular volume expander, decreasing the risk of renal failure, pulmonary edema levels, and significantly reducing extravascular pulmonary water. 30% demonstrate the effectiveness of other fluids as the first line in fluid resuscitation due to their market accessibility. 10% demonstrate the effectiveness of both albumin and other fluids in increasing left ventricular stroke work and systolic volume. Conclusions: Of the 10 articles, 6 demonstrate the effectiveness of albumin in patients with sepsis by reducing mortality rates, 3 demonstrate that other fluids are more effective than albumin because it showed no change in mortality, and 1 demonstrates that both albumin and other fluids are effective in increasing cardiac index.
Acceso abierto
Egg Albumin Germ Tube Test Performance in Identifying Candida Albicans, 2020
(Universidad Privada Norbert Wiener, 2020-03-11) Arenas Pillco, Liliana Veronica; Rosas Paytan, Ruth Victoria; Rojas León, Roberto Eugenio
Candida albicans identification is performed with the germ tube test using human serum, which, despite being accessible, is not biosecure. Various researchers have conducted this test using egg albumin with satisfactory results but did not measure its performance. The aim of this study was to evaluate the performance of the germ tube test with egg albumin in identifying Candida albicans. This was a quantitative, observational, analytical, cross-sectional study conducted at the Norbert Wiener University Laboratory, following INS protocols. The germ tube test was performed using egg albumin from Gallus gallus domesticus, employing 118 Candida albicans strains and 12 non-Candida albicans strains. Sensitivity, specificity, false positives, false negatives, and efficiency were: 95.8%, 100%, 0%, 4.2%, and 96.2%, respectively. The Kappa index was 0.81, indicating high agreement with the reference method. Following SEIMC criteria, it was concluded that the test using egg albumin is acceptable for identifying Candida albicans and is an economical, accessible, and, above all, safe medium for laboratory personnel.