Examinando por Materia "Soy, Adipokines Adiponectin, Systematic review, Meta-analysis"

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    Systematic review and meta-analysis of randomized, controlled trials on the effects of soy and soy products supplementation on serum adiponectin levels
    (Elsevier Ltd, 2022-07-07) Mahmudiono, Trias; Khaydarov, Nodirjon Kadirovich; Jasim, Saade Abdalkareem; Hammid, Ali Thaeer; Failoc-Rojas, Virgilio E.; Shalaby, Mohammed Nader; MehranNouri, Behrooz Jannatg; Abdulmnannan Fadel j
    “ackground and aims: Our aim in this meta-analysis was to determine the effect of soy and soy product supplementation on serum adiponectin levels. Method: A systematic search was conducted using Medline (PubMed and Web of Science), Scopus, and Cochrane Library for eligible trials up to August 2020. A random-effects model was used to pool calculated effect sizes. Results: Seven trials were included in the overall analysis. Our analysis showed that soy and soy product supplementation did not significantly affect adiponectin concentrations (WMD ¼ 0.77 mg/ml, 95% CI: 0.61, 2.15, P ¼ 0.27) in comparison with a placebo. The between-study heterogeneity was high (I2: 68.2%, P ¼ 0.004). Subgroup analysis, based on participants’ health status and duration of the supple- mentation, could not detect the potential source of the observed heterogeneity. In addition, subgroup analysis showed that the effect was not statistically significant in all subgroups. Conclusion: Overall, soy and soy product supplementation did not change the circulatory adiponectin levels. In addition, the results were not affected by the participant's health status and duration of sup- plementation. However, further studies are needed to confirm the present results“