Examinando por Materia "Stomach"

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    Seguridad y actividad antiulcerosa de la savia liofilizada de la musa acuminata colla (plátano de seda) en ratas inducidas a úlcera gástrica e in vitro
    (Universidad Privada Norbert Wiener, 2017) Tasayco Yataco, Nesquen José; Chávez Flores, Juana Elvira
    The objective was to determine to the extent that the lyophilized sap of Musa acuminata Colla affects the safety and antiulcer activity in rats induced gastric ulcer and in vitro. Safety was evaluated at single dose in albino mice and at repeated doses for 28 days in Holtzmann rats. Anti-ulcer activity was evaluated in rats induced gastric ulcer with indomethacin 80 mg / kg orally. In the in vitro study the activity against Helicobacter pylori was evaluated. Results; The mean lethal dose was 10000 mg / kg, the repeated dose toxicity test showed no toxic symptoms or significant changes in hematological parameters and blood chemistry. The 800 mg/Kg dose in the antiulcer activity produced 86% inhibition compared to the control group which obtained 65% inhibition; The activity against Helicobacter pylori at concentrations of lyophilized sap of 1000 ug / mL, 500 ug / mL, 250 ug / mL and 125 ug / mL was found to be inactive, antiulcer activity is probably due to the presence of tannins, alkaloids and flavonoids. Concluding that lyophilized sap of Musa acuminata Colla has been shown to be safe and have antiulcer activity in rats but have no in vitro activity against Helicobacter pylori.