Examinando por Materia "Tejido Linfoide"

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Acceso abierto
Morphological alterations" of the lymphoid series in relation to the degree of severity of covid-19, in patients over 60 years of age, attended at the Laura Esther Rodríguez Dulanto Hospital in Supe Lima, period August - December 2020
(Universidad Privada Norbert Wiener, 2023-10-01) Lozada Guevara, María Nelly; Huamán Cárdenas, Victor Raul
Morphological alterations in the lymphoid series are associated with several factors and foreign agents, such as insecticides, bacteria, fungi, parasites, and viruses. Among the foreign agents mentioned, the most damaging is the SARS-CoV-2 virus, which directly infects the epithelial endothelium of type II pneumocytes in the lungs. There are international and national studies that show how patients with severe illness compared to those with mild illness present a significantly lower lymphocyte count; in severe cases, this is at the expense of CD4+ lymphocytes, CD8+ lymphocytes, and B lymphocytes (CD19+). This essentially reflects lymphopenia caused by the cells responsible for humoral and cytotoxic immunity. This research project will employ a hypothetical inductive method, with a quantitative and applied approach. The experimental design will be observational with a cross-sectional measurement. The aim of this research is to study the "Morphological Alterations" of the Lymphoid Series in relation to the severity of COVID-19 in patients over 60 years old treated at the Laura Esther Rodríguez Dulanto Hospital in Supe - Lima, from August to December 2020. The population will consist of 219 epidemiological records of patients with a positive COVID-19 diagnosis. Data will be collected using the SIS COVID-19 program, laboratory reports such as peripheral blood smear results, antigen tests, medical records from the database, and molecular test results.