Examinando por Materia "Vitamin D"

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Critical review: effect of vitamin d on multiple sclerosis management.
(Universidad Privada Norbert Wiener, 2022-04-21) Infantes Vilca, Edwin Ronald; Bohórquez Medina, Andrea Lisbet
Recent studies indicate that multiple sclerosis has been increasing worldwide, being the main cause of neurological disability in young adults. The objective of this critical review was to know the effect of vitamin D supplementation in the management of patients with multiple sclerosis. Through the principles of evidence-based nutrition (NuBE), a bibliographic search was carried out with MeSH and DeCS descriptors and related terms, in the Scopus, Embase, Web of Science, Pubmed and Cochrane databases. After the CASPE critical reading analysis, the article was selected: “Effectiveness of vitamin D supplementation in the management of multiple sclerosis: A systematic review”, which presents a level of IA evidence and a strong recommendation grade. The analysis allows us to conclude that, although the vitamin presents positive effects as part of the treatment of multiple sclerosis, it is still not conclusive given the heterogeneity of the studies; however, it is observed that supplementation is very favorable in those who have the vitamin D levels at the lower limit, therefore, it is important to analyze vitamin D levels in patients with multiple sclerosis.
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Critical review: effect of vitamin d supplementation in tuberculosis patients
(Universidad Privada Norbert Wiener, 2022-04-19) Asmad Asmat, Teresa de Jesús; Bohórquez Medina, Andrea Lisbet
Tuberculosis is an infectious disease transmitted via the respiratory system. This secondary research, titled "Effect of vitamin D supplementation in tuberculosis patients," aimed to determine the nutritional effects of oral supplementation in tuberculosis patients. Clinical studies on the efficacy of vitamin D supplementation in tuberculosis patients were reviewed using the Evidence-Based Nutrition (NuBE) methodology. The search for information was conducted in PUBMED, MEDLINE, SCIELO, SCOPUS, SCIENCE DIRECT, with 96 articles found. Twenty articles were selected and evaluated using the CASPE critical reading tool, with one article selected that provided evidence in response to the clinical question, having an evidence level I and recommendation grade I, according to the researcher’s expertise. The critical commentary concludes that tuberculosis is relevant for research by nutritional health professionals and others, as it helps understand various publications on vitamin D supplementation in tuberculosis patients worldwide and nationally.
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Critical review: Effect of vitamin D supplementation on the health of women with polycystic ovary syndrome
(Universidad Privada Norbert Wiener, 2023-03-02) Ruesta Gutierrez, Marysabel del Pilar; Bohórquez Medina, Andrea Lisbet
Polycystic ovary syndrome (PCOS) is characterized as a hormonal disorder with dermocosmetic, endocrinometabolic, and gynecological manifestations, affecting 10% of women of reproductive age worldwide. Vitamin D is a nutrient considered a steroid hormone with a similar action to progesterone, and its deficiency may be associated with gynecological diseases. The present secondary research titled 'Critical Review: Effect of Vitamin D Supplementation on the Health of Women with Polycystic Ovary Syndrome' aimed to evaluate the effects of vitamin D supplementation in women with PCOS. The Evidence-Based Nutrition (NuBE) methodology was used. Information was searched on Google Scholar, Dimensions, and Elsevier, and the database was obtained from PubMed, Science Direct, Oxford Academic Journals, and Scielo, resulting in 61 articles, of which 19 were selected and critically evaluated using the CASPe tool. The meta-analysis 'Vitamin D Supplementation in the Treatment of Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Clinical Trials' was chosen, which has a level of evidence AI and a strong recommendation grade, according to the researcher's experience. The critical review concluded that vitamin D supplementation is beneficial for the health of women with PCOS. Further research with larger sample sizes and extended study periods is needed to strengthen the results found in this meta-analysis.
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Critical review: effect of vitamin d supplementation on the susceptibility and / or evolution of acute respiratory infections in people over 18 years old
(Universidad Privada Norbert Wiener, 2022-07-13) Palma Gutierrez, Edgardo Jhoffre; De León Delgado, Joel
Serum vitamin D deficiency has been reported to be significantly associated with poor outcomes in acute respiratory infections (incidence and severity). However, the results and outcomes of vitamin D supplementation in clinical trials have been heterogeneous. The information search was carried out in the Medline and Cochrane databases, finding 20 articles on the topic, 8 articles were selected that were evaluated by the CASPE critical reading tool, finally selecting the clinical trial titled: “High Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial”, which has a level of evidence I and a Strong recommendation grade, according to the researcher's expertise. The critical comment allowed us to conclude that supplementation with 100,000 IU of vitamin D monthly for 12 months reduced the incidence of acute respiratory infections in the operated population.
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Critical review: relationship between serum vitamin D levels and breast cancer risk.
(Universidad Privada Norbert Wiener, 2021-07-13) Morales Rios, Edith Jacinta; Bohórquez Medina, Sofia Lorena
Breast cancer is currently the cancer that affects women with the highest prevalence, positioning itself as the type of cancer with the highest mortality rate worldwide. On the other hand, vitamin D is one of the micronutrients with various fundamental metabolic and physiological functions in some organs of the human body, such as the liver, heart, lungs, intestines, bones, and mammary glands, where it acts as a vitamin receptor. D (VDR). In addition, it exerts immunomodulatory and antiproliferative effects, therefore, evidence-based research is required to analyze the importance of this vitamin in the prevention, development, as well as treatment of breast cancer. By virtue of the above, the present research: “critical review: Relationship between serum levels of vitamin D and the risk of breast cancer”, aimed to identify the relationship between serum levels of vitamin D and the risk of breast cancer. . Therefore, the following research question was asked: “Are low levels of vitamin D related to an increased risk of breast cancer in adult women?” The search for scientific articles was carried out in five scientific bases, SCOPUS, PUBMED, EMBASE, WEB OF SCIENCE, SCIENCE DIRECT. 121 articles were found, of which 23 were selected by carrying out the evaluation, and selection of the article for the critical comment, which is a systematic review and meta-analysis titled: “Vitamin D and breast cancer: A systematic review and meta-analysis of observational studies”, with the highest level of evidence and recommendation (I and I respectively). After analyzing the selected article, by writing the critical comment, it can be concluded that 25 (OH) D deficiency was directly related to breast cancer and that sun exposure can help prevent breast cancer. more efficient than ingesting it through food supplements.
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Critical review: relationship between serum vitamin D levels and survival of patients with colorectal cancer
(Universidad Privada Norbert Wiener, 2022-10-18) Gonzalez Huamani, Jose Smith; Palma Gutiérrez, Edgardo Jhoffire
An information search was carried out in the Medline and Cochrane databases, finding 60 articles, 6 being selected, which have been evaluated by the CASPE critical reading tool, finally the selected article allowed us to conclude that there is a significant association between the highest concentrations. high levels of vitamin D in the blood and better survival in patients with colorectal cancer.
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Critical review: Supplementation of vitamin D and its analogs in the reduction of secondary hyperparathyroidism in patients with CKD.
(Universidad Privada Norbert Wiener, 2020-12-18) Meza Pérez, Karina Lisbeth; Bohórquez Medina, Andrea Lisbet
The following secondary research work called a critical review: Supplementation of vitamin D and its analogues in the reduction of secondary hyperparathyroidism presented in patients with CKD, aims to determine whether treatment with doses of vitamin D and its analogues reduces secondary hyperparathyroidism ( HPTS). The clinical question posed was: Will vitamin D supplementation (ergocalciferol, cholecalciferol and analogues) reduce secondary hyperparathyroidism in Men and Women over 18 years of age who suffer from secondary hyperparathyroidism with CKD? The Evidence-Based Nutrition (NuBE) methodology was taken as a reference. Various sources of information were collected in Pubmed, Scielo, finding 29 articles, 15 being selected whose analysis was carried out by the CASPE critical reading tool, the double-blind RCT titled as High doses of cholecalciferol alleviate the progression of hyperparathyroidism in patients with CKD in stages 3 and 4: result of a controlled, randomized, double-blind 12-week study, finding a level of evidence B I with a grade of recommendation strong, according to the researcher's evaluation.
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Critical review: The effect of cholecalciferol supplementation improves vascular function in adult patients with chronic kidney disease.
(Universidad Privada Norbert Wiener, 2022-05-25) Ríos Barbarán, Martín; Dávila Córdova, Jennifer Estefania
Chronic kidney disease (CKD) is a public health problem of global relevance; since it is related to the increased risk of cardiovascular disease as kidney failure progresses, vitamin D deficiency is associated with mortality in patients with CKD, which could mitigate the risk of cardiovascular disease in CKD. The present secondary research entitled: Critical review: The effect of cholecalciferol supplementation improves vascular function in adult patients with chronic kidney disease", aimed to know the effect of cholecalciferol supplementation in improving vascular function in adult patients with chronic kidney disease. The clinical question was: Does the effect of cholecalciferol supplementation improve vascular function in adult patients with Chronic Kidney Disease? The Nutrition Based on Evidence (NuBE) methodology was used. The information search was performed in PUBMED and COCHRANE, finding 37 articles, of which 11 were selected and evaluated by the critical reading tool CASPE. Finally, the Randomized Clinical Trial entitled "A randomized trial of vitamin D supplementation on vascular function in CKD" was selected, which has an AI level of evidence and Strong Grade of Recommendation, according to the researcher's expertise. The critical commentary allowed to conclude that the use of cholecalciferol supplements improves vascular function through endothelial function indicators and circulating biomarkers, with cholecalciferol supplementation being considered as a nutritional treatment to positively improve in adult patients with chronic kidney disease; at the same time, it is proposed to continue carrying out clinical studies in which the number of participants is greater and the intervention period similar to the selected clinical trial.
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Critical review: vitamin D supplementation on plasma calcidiol levels and survival in colorectal cancer patients.
(Universidad Privada Norbert Wiener, 2022-09-06) Puente Villena, Diego Alberto; Bohórquez Medina, Andrea Lisbet
Secondary research titled: Critical review: “Vitamin D supplementation on plasma calcidiol levels and survival in patients with colorectal cancer.” We aimed to identify the effect that vitamin D supplementation has on plasma calcidiol levels and survival in patients with colorectal cancer. The clinical question was: Does vitamin D supplementation increase plasma vitamin D levels and improve survival rate in patients with colorectal cancer? The Evidence-Based Nutrition methodology was used. The information search was carried out in Science Direct, Pubmed, Splingerlink, Lilacs, Latindex and Scielo, finding 60 articles, 15 being selected that have undergone exhaustive selection with the CASPE tool such as “the effect of vitamin D supplementation on survival in patients with “colorectal cancer: systematic review and meta-analysis of randomized controlled trials.” which met the expectations of the objectives proposed herein, and also obtained a STRONG recommendation grade and A1 level of evidence. Vitamin D supplementation at doses of 2000 IU to 4000 IU showed improvements in plasma calcidiol levels and overall survival and relapse-free survival rates in patients with colorectal cancer.
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Effect of oral vitamin d supplementation on survival of adult colorectal cancer patients.
(Universidad Privada Norbert Wiener, 2020-12-11) Julca Rupay, Marlene Rosario; Palma Gutiérrez, Edgardo Jhoffire
This critical review aimed to analyze the effect of oral vitamin D supplementation and its role in the survival of adult patients with colorectal cancer. The clinical question was: Does oral vitamin D supplementation increase survival time in adult patients with colorectal cancer? The Evidence-Based Nutrition (NuBE) methodology was used. Information was searched in Medline, Wiley Online Library, HINARI, Scielo, and Redalyc, finding 225 articles, of which 6 were selected and evaluated using the CASPE critical reading tool. The randomized clinical trial titled 'Effect of high-dose vs. standard-dose vitamin D3 supplementation on progression-free survival in patients with advanced or metastatic colorectal cancer: The SUNSHINE randomized clinical trial' was chosen, possessing a level of evidence I and a strong recommendation grade. The critical commentary concluded that high-dose vitamin D improved survival in colorectal cancer patients compared to those who consumed the standard dose. Further studies are needed to extrapolate these results to the general population.
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Effect of Vitamin D on Glycemic Status in Patients with Type 2 Diabetes
(Universidad Privada Norbert Wiener, 1905-07-09) Bautista Herrera, Roberto Carlos; Benites Azabache, Juan Carlos
Introduction: A search for scientific articles with a randomized clinical study design was conducted in databases such as PUBMED, TRIPDATABASE, SciELO, BVS, LILACS, and GOOGLE SCHOLAR, aiming to evaluate the effect of vitamin D on glycemic status in patients with type 2 diabetes. Only articles meeting the inclusion criteria and indexed from 2010 to 2016 in English, Spanish, and Portuguese were included. A search strategy was established for each information source. Objective: To determine the effect of vitamin D on the glycemic status of patients with type 2 diabetes. Results: 50 articles were selected for evaluation. After applying the inclusion criteria and checking for bias, 3 articles were chosen for a systematic review. Conclusion: Vitamin D administration significantly improves glucose control in patients with type 2 diabetes by lowering blood glucose levels, demonstrating safety and efficacy.
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Effectiveness of supplementation with vitamin D plus calcium for the prevention of fractures in older adults.
(Universidad Privada Norbert Wiener, 2018-08-04) Santa Cruz Saavedra, Grace Vanessa; Prado Vidal, Rosaura Micaela; Avila Vargas Machuca, Jeannette Giselle
Objective: To systematically analyze the available evidence from studies on the effectiveness of vitamin A and iron supplementation in the prevention of anemia in children under 5 years of age. Materials and Methods: The systematic review of 10 scientific articles found on the effectiveness of vitamin A and iron supplementation in the prevention of anemia in children under 5 years of age was conducted using the following databases: Cochrane, Lilacs, Scielo, Medline, PubMed. All articles were analyzed according to the grading scale to determine their strength and quality of evidence. Results: 90% (9/10) demonstrate the effectiveness of vitamin A and iron supplementation in preventing anemia in children under 5 years of age, while 10% of the reviewed articles conclude that more studies are needed to demonstrate the effectiveness of vitamin A and iron supplements in preventing anemia in children under 5 years of age. Conclusions: Of the 10 articles systematically reviewed, 9 articles show the effectiveness of vitamin A and iron supplementation in preventing anemia in children under 5 years of age, while 2 articles conclude that larger population studies are needed to demonstrate the effectiveness of vitamin A and iron supplementation in preventing anemia.
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Effectiveness of vitamin d supplementation in patients with covid 19
(Universidad Privada Norbert Wiener, 2022-05-16) Sanchez Gaspar, Marco Antonio; Bohórquez Medina, Andrea Lisbet
Nutritional intervention, specifically vitamin D supplementation in the intensive care unit, helps prevent complications associated with critically ill COVID-19 patients, according to clinical studies. This secondary study, titled "Effectiveness of Vitamin D Supplementation in Critically Ill COVID-19 Patients," was classified as a critical review based on its methodological structure. Its purpose was to analyze the effectiveness of vitamin D supplementation concerning primary outcomes (mortality) and secondary outcomes (morbidity, infection, inflammatory status, days on mechanical ventilation, nutritional support, polypharmacy, hospital stay, and hospital costs). The clinical question was: What is the effectiveness of vitamin D supplementation in critically ill patients with COVID-19 regarding the reduction of mortality, morbidity, infection, inflammatory status, days on mechanical ventilation, nutritional support, polypharmacy, hospital stay, and hospital costs? For the methodological development, evidence-based nutrition (EBN) guidelines were followed. Subsequently, to carry out the bibliographic search, the following scientific databases were used: PubMed, Science Direct, and Clinical Trials; a total of 22 clinical studies were selected, with 10 articles meeting the eligibility criteria, which were critically evaluated by the researcher using the CASPE tool. Finally, the RCT “Vitamin D Supplements, COVID-19, and Disease Severity: A Meta-analysis” was selected, which has a level 2 evidence and a strong recommendation grade, according to the researcher’s criteria. The critical review concluded that vitamin D supplementation is effective in reducing days on mechanical ventilation and hospital stay in critically ill COVID-19 patients.
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Effectiveness of vitamin D supplementation in the prevention of respiratory infections in children.
(Universidad Privada Norbert Wiener, 2018-08-04) Chu Ugaz, Martha Yuliana; Avila Vargas Machuca, Jeannette Giselle
Objective: To systematically analyze the available evidence from studies conducted on the effectiveness of vitamin D supplementation in preventing respiratory infections in children. Material and Method: The systematic review of 10 scientific articles was analyzed according to the GRADE scale to determine their strength and quality of evidence; 80% (8/10) correspond to the methodological design of methodological review; 10% (1/10) to meta-analysis and clinical studies, respectively. Results: Of the articles reviewed, 70% show the effectiveness of vitamin D supplementation in preventing respiratory infections in children; 20% do not provide evidence of the effectiveness of vitamin D in preventing respiratory infections in children, and 10% state that further studies are needed to investigate the effects of vitamin D supplementation in preventing respiratory infections. Conclusions: Of the 10 articles systematically reviewed, 7 provide evidence of the effectiveness of vitamin D supplementation in preventing respiratory infections in children; 2 do not provide evidence of the effectiveness of vitamin D in preventing respiratory infections in children, and 1 study concludes that larger studies are needed to investigate the effects of vitamin D supplementation in preventing respiratory infections.
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Effectiveness of vitamin D supplementation to prevent osteopenia in premature newborns
(Universidad Privada Norbert Wiener, 2018-11-24) Albornoz Paredes, Erika Rocio; Cerna Portal, Lily Yovanna; Avila Vargas Machuca, Jeannette Giselle
The constant investigation of the 24 scientific articles found on the effectiveness of the use of vitamin D supplement to prevent osteopenia in premature newborns, after applying the selection criteria (8 repeated) by title relevance, 10 articles were included for the study, were found in the following database Pubmed, Cochrane, Medline, Scielo, which were analyzed according to the Grade scale to determine their strength and quality of evidence. RESULT: A total of 9 articles were obtained from the research, representing 90% (9/10) of the methodological design of methodological review and 1% (1/10) of meta-analysis. Of the 10 articles systematically studied, 100% managed to demonstrate the effectiveness of the use of vitamin D supplement to prevent osteopenia in premature newborns. CONCLUSIONS: It is obtained that of the 10 articles systematically analyzed, 100% identify the effectiveness of the use of vitamin D supplement to prevent osteopenia in premature newborns.
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Nutritional supplementation with vitamin d in immunosuppressed tuberculosis patients
(Universidad Privada Norbert Wiener, 2023-06-08) Castillo Rodríguez, Martin Hernán; Bohórquez Medina, Andrea Lisbet
Nutritional intervention is important for the recovery of malnourished patients with tuberculosis and those immunosuppressed. The objective was to identify the nutritional improvement variables due to vitamin D supplementation (micronutrient) in patients with tuberculosis and immunosuppressed individuals. The methodology used was Evidence-Based Nutrition (NuBE). The evidence and information were explored in PUBMED, MEDLINE, SCIELO, SCOPUS, and SCIENCE DIRECT databases. For the critical review, an article with a randomized, double-blind, placebo-controlled trial titled "Efficacy of Vitamin D Supplementation for Preventing Pulmonary Tuberculosis and Mortality in HIV: A Randomized, Double-Blind, Placebo-Controlled Trial" was selected. It has an AI level of evidence and a strong recommendation grade, according to the researcher’s expertise. The critical review concluded that the randomized double-blind trial is useful in answering the question and shows sufficient evidence that vitamin D supplementation has little significant effect, with similar results in the placebo-controlled groups.
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Revisión crítica: efecto de la suplementación de vitamina d en los niveles de calcitriol de pacientes adultos con enfermedad renal
(Universidad Privada Norbert Wiener, 2025-05-15) Castillejo Julca, Fabby Sonia; Ponce Castillo, Melissa
La investigación secundaria presente que lleva por título revisión crítica: Efecto de la suplementación de vitamina d en los niveles de calcitriol de pacientes adultos que presentan enfermedad renal (ER), tuvo como meta identificar el efecto de la intervención en los parámetros de resultados a través de la revisión bibliografía. Tuvo por objetivo identificar el vacío de conocimiento y valorar el efecto que tiene la suplementación mediante vitamina D en los niveles de calcitriol. La pregunta de índole clínico fue: ¿Cuáles es efecto de la suplementación de vitamina D en los niveles de calcitriol de pacientes adultos con enfermedad renal? Se empleó la metodología Nutrición Basada en Evidencia (NuBE). Se seleccionaron 11 de los 31 artículos encontrados con la ayuda de información en MEDLINE, PUBMED, SCIENCE DIRECT, SCIELO y SCOPUS, y se valoraron mediante lectura crítica CASPE, eligiendo el Ensayo Clínico Aleatorizado titulado como "Colecalciferol versus ergocalciferol para la reposición de 25-hidroxivitamina D (25(OH)D) en la enfermedad renal crónica: un ensayo clínico aleatorizado", que, conforme a la experiencia del investigador, tiene un Grado de Recomendación I y un Nivel de Evidencia B. El comentario crítico llevó a concluir que los hallazgos relacionados a los niveles totales de 25-hidroxivitamina D (25(OH)D) a las 12 semanas, el grupo de colecalciferol tuvo un mayor aumento en los niveles totales de 25(OH)D a comparación con el grupo de ergocalciferol (45.0 ng/ml vs 30.7 ng/ml, p<0.01). No obstante, a las 18 semanas (6 semanas después de suspender el tratamiento), no fueron encontradas significativas diferencias entre los grupos en el cambio de los niveles totales de 25(OH)D (22.4 ng/ml vs 17.6 ng/ml, p= 0,17). En cambio, en la hormona paratiroidea (PTH) el grupo de colecalciferol mostró una mayor reducción media en los niveles de PTH en comparación con el grupo de ergocalciferol (-15,3 pg/ml vs 2,3 pg/ml, p=0,14 en el análisis de rango).
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Revisión crítica: impacto de los niveles de vitamina d en el paciente pediátrico con leucemia
(Universidad Privada Norbert Wiener, 2025-03-26) Escobedo Vara, Anderson Jose; Bohórquez Medina, Andrea Lisbet
La leucemia es una clase de cáncer que repercute en los glóbulos blancos y puede ser particularmente difícil de tratar en los pacientes de temprana edad. La suplementación con vitamina D ha tenido un impacto sobre los niveles sanguíneos de vitamina D en niños con leucemia. La investigación presente con título de revisión crítica: “Impacto de los niveles de vitamina D en pacientes pediátricos con leucemia” cuyo objetivo era realizar una apreciación crítica profesional fundamentada en el estudio de investigaciones científicas y estudios clínicos relacionados con entender la correlación entre los niveles de vitamina D y el progreso de la leucemia en niños. El interrogante del análisis clínico consistió en: ¿Cuál es el impacto de la vitamina D y su suplementación en niños con leucemia? La metodología de Nutrición Basada en Evidencia (NuBE) fue utilizada. La evaluación de la información se realizó en PUBMED, COCHRANE, SPRINGER, SCOPUS, OVED, SCIENCIE DIRECT, BASE (Bielefeld Academic Search Engine). Se lograron 32 artículos, de los cuales se escogieron 15 para ser evaluados mediante la realización de la lectura crítica CASPE. Finalmente, se eligió el metanálisis o revisión sistemática titulado “Are Pediatric Cancer Patients a Risk Group for Vitamin D Deficiency? A Systematic Review” que presenta rango de evidencia “AI” y Grado de Recomendación “Fuerte”, de acuerdo a la experiencia del investigador. El análisis crítico concluyó que la carencia de vitamina D es frecuente entre los pacientes pediátricos con leucemia. Aunque no hay estudios de gran magnitud que confirmen la efectividad de suplementar con vitamina D para mejorar los resultados en el tratamiento del cáncer, existe una elevación notable entre niveles adecuados de vitamina D y un pronóstico más optimista.