Examinando por Materia "beta-Lactam Resistance"

Seleccione resultados tecleando las primeras letras
Mostrando 1 - 3 de 3
  • Miniatura
    ÍtemAcceso abierto
    Clinical-epidemiological characteristics of patients hospitalized with urinary tract infections caused by BLEE-producing Enterobacteriaceae at Carlos Lanfranco La Hoz Hospital, 2017
    (Universidad Privada Norbert Wiener, 2019-05-07) Villarreal Guevara, Nathaly Marbelly; Benites Azabache, Juan Carlos
    This research is a descriptive, cross-sectional, and retrospective study. A total of 148 data points from patients were collected, including age, sex, source service, prior antibiotic use, hospitalization time, and the enterobacteria isolated in their urine cultures. The statistical software EpiInfo and Excel were used for frequency analysis and graphical representation. The results showed that the prevalence of patients with UTIs positive for extended-spectrum beta-lactamase (ESBL)-producing enterobacteria was 23.2%. Of the 148 cases, 81.8% were women, the mean age was 49.4 years, 66.2% came from general medicine, the average hospitalization time was 12.3 +/- 13.5 days, and 68.9% of the enterobacteria isolated and positive for ESBL were Escherichia coli. The most frequent comorbidities were diabetes and hypertension, and 26.3% of the patients had received ceftriaxone prior to confirmation of infection by ESBL.
  • Miniatura
    ÍtemAcceso abierto
    Diagnostic performance of chromagar esbl versus the vitek 2 automated system for the phenotypic detection of extended spectrum betal-actamase in urocultures, Lima 2023
    (Universidad Privada Norbert Wiener, 2024-04-28) Tena Contreras, Ruth Araceli; Moya Salazar, Jeel Junior
    Antibiotic resistance in bacteria is a growing public health concern worldwide. A set of factors affects the reduction of antibiotic resistance, with bacteria often showing intrinsic and extrinsic resistance mechanisms to main drugs. One specific type of antibiotic resistance is the production of extended-spectrum beta-lactamases (ESBLs), a resistance mechanism that has emerged as a significant problem in recent years. ESBL production confers resistance to a wide range of beta-lactam antibiotics, and infections caused by ESBL-producing bacteria are associated with increased morbidity, mortality, and healthcare costs. There is currently no consensus on the optimal approach to ESBL detection, as many health centers lack the materials necessary for diagnosis through the mentioned methods. Additionally, the performance of these methods can vary depending on the type of ESBL and the bacterial species being tested. Therefore, there is an important need for continuous evaluation and validation of ESBL diagnostic methods to ensure their accuracy and reliability.
  • Miniatura
    ÍtemAcceso abierto
    Phenotypic and molecular characterization of strains producing extended-spectrum beta-lactamases isolated from pediatric patients, 2018
    (Universidad Privada Norbert Wiener, 2019-07-30) Ancajima Ballena, Maria Elena; Sotelo Alejos, Rocío Maribel; Benites Azabache, Juan Carlos
    The resistance to beta-lactams in the pediatric population has not been previously evaluated in our community. This research aimed to characterize phenotypically and molecularly the extended-spectrum beta-lactamase (ESBL)-producing strains isolated from pediatric patients during the second semester of 2018. The study was prospective, cross-sectional, and descriptive, involving 30 pediatric patient samples. Data analysis was performed using the SPSS v21.0 statistical package, and tables and graphs were created in MS-Excel 2010. ESBL-producing strains were identified using antimicrobial susceptibility methods and CLSI breakpoint criteria, and the genes blaTEM, blaSHV, and blaCTX were characterized using conventional PCR. Most of the samples analyzed were urine (90%), with E. coli (76%) and K. pneumoniae (10%) being the most frequent bacterial agents. E. coli strains presented the blaCTX gene (87%), the blaTEM gene (83%), and the blaSHV gene (74%). Two strains (66.7%) of K. pneumoniae presented the blaCTX and blaTEM genes simultaneously, and two strains (66.7%) of P. mirabilis presented the blaCTX gene. The phenotypic and molecular characteristics of ESBL-producing strains isolated from pediatric patients indicated bacterial resistance, with the blaCTX gene being the most frequently found.