Examinando por Autor "Canelo Chavez, Luis Lorenzo"

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    Prevalencia de reacciones adversas en pacientes tratados con L-asparaginasa del servicio de Hematología Pediátrica del HNERM, enero 2018–febrero 2019
    (Universidad Privada Norbert Wiener, 2021-08-12) Canelo Chavez, Luis Lorenzo; Caldas Herrera, Emma
    The objective of this research was to determine the prevalence of adverse reactions to L-asparaginase (L-ASP) in children under 15 with acute lymphoblastic leukemia (ALL) in the pediatric hematology service of the HNERM from January 2018 to February 2019. Methodology: The approach was quantitative, with a basic, descriptive, and retrospective research type. The population consisted of 56 patient clinical records, in which the drug was used 382 times. Results: The prevalence was 3.93%. The most common ADR was erythematous papules, dermal rash, or urticaria (13.33%). The incidence was frequent (86.7%), and 60% of reactions were of mild severity. 100% of reactions were type B ADRs, and 93.3% were to native L-asparaginase. The prevalent regimen and dose was block I and 100 IU SC (20%). The causality of the ADRs, using the Karch and Lasagna Algorithm, was 33.3% mild, 60% moderate, and 6.67% severe. It was also considered possible that ADRs would appear in 53.33% of cases. Conclusion: It is concluded that the prevalence of adverse reactions to L-asparaginase in children under 15 with ALL, in the pediatric hematology service of the HNERM from January 2018 to February 2019, is 3.93%.