Examinando por Autor "Jaramillo Briceño, Marilú Ricardina"

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Actividad antimicótica "in vitro" del aceite esencial del fruto maduro de Schinus molle L. (molle) frente a cepa de Candida albicans ATCC 10231
(Universidad Privada Norbert Wiener, 2019-07-09) Zambrano Ospinal, Agar Leonor; Jaramillo Briceño, Marilú Ricardina
This study was developed with the objective of evaluating the in vitro antifungal activity of the essential oil (EO) from the mature fruit of Schinus molle L. (Molle) against the Candida albicans ATCC 10231 strain. Methodology: The methodology used was experimental, explanatory, quantitative, and applied. The fruit was collected in the Huamanga province (Ayacucho). The essential oil (EO) was extracted by steam distillation. The antifungal activity was evaluated using the Kirby-Bauer method (disk diffusion). The strain was seeded on 18 plates with Sabouraud Dextrose Agar at a turbidity of 0.5 McFarland. The EO was evaluated at concentrations of 40%, 60%, 80%, and 100%, using Fluconazole 25 µg as a positive control and dimethyl sulfoxide as a negative control. The inhibition zones were measured with a digital vernier caliper at 24, 48, and 72 hours. Results: The EO of Schinus molle L. showed inhibition halos of 6 mm at 40 and 60%, 9.7 mm at 80%, and 12.3 mm at 100%. It is concluded that the EO at 40 and 60% presented no activity, but at 80 and 100% it presented antifungal activity against the Candida albicans ATCC 10231 strain.
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Buenas prácticas de almacenamiento para la correcta conservación del producto farmacéutico en las boticas de Bellavista Callao 2021
(Universidad Privada Norbert Wiener, 2021-10-06) Cuya Taipe, Mary Luz; Pajuelo Lopez, Jaime Enrique; Jaramillo Briceño, Marilú Ricardina
The objective of this research was to evaluate whether Good Storage Practices (GSP) are applied for the proper conservation of pharmaceutical products in drugstores in the Bellavista district of Callao, 2021. Methodology: A deductive method with a quantitative approach was applied. The study was also basic and had a descriptive, longitudinal, and prospective level. Results: The average compliance with GSP among the drugstores regarding the quality assurance system was 18.00% (LOW) on the first visit, 27.00% (LOW) on the second, and 35.00% (LOW) on the third. For facilities and distribution, concerning location and required areas, compliance was 40.00% (LOW) on the first visit, 47.00% (LOW) on the second, and 50.00% (MEDIUM) on the third. For documentation (official books, SOPs, etc.), compliance was 29.00% (LOW) on the first visit, 39.00% (LOW) on the second, and 54.00% (MEDIUM) on the third. For human resources (knowledge, understanding, and compliance with the GSP Manual), it was 23.00% (LOW) on the first visit, 35.00% (LOW) on the second, and 36.00% (LOW) on the third. It is worth noting that the drugstores did not have temperature-sensitive products and thus did not require refrigeration or freezer units. Conclusion: The evaluated points of GSP in the five pharmaceutical establishments (drugstores) had a compliance of 27.50% (LOW) on the first visit, 37.00% (LOW) on the second, and 43.75% (LOW) on the third. However, it is important to highlight that they showed a progressive improvement in GSP compliance.
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Características clínicas y epidemiológicas en pacientes con diagnóstico COVID-19 del centro de emergencias San Pedro del distrito Chorillos, Lima Metropolitana, 2021
(Universidad Privada Norbert Wiener, 2022-04-28) Becerra Guevara, Liliana; Castro Delgado, Karen Lisset; Jaramillo Briceño, Marilú Ricardina
The objective of this study was to determine the relationship between clinical and epidemiological characteristics in patients with a COVID-19 diagnosis at the San Pedro Emergency Center in the Chorrillos district. Method: This study used a quantitative approach, with an applied type, a non-experimental design, and a correlational level. The population was composed of 214 epidemiological forms from patients with a positive COVID-19 diagnosis, and a sample of 179 forms was considered. The instruments used were epidemiological and laboratory forms that were adapted for the research. For statistical analysis, SPSS Version 25.0 and the Chi-squared test of independence were used at a 5% significance level. Results: In the analysis of the relationship between clinical and epidemiological characteristics, the p-value (p = 0.013) was found to be less than 0.05, leading to the rejection of the null hypothesis and the acceptance of the alternative hypothesis. At a 95% confidence level, it is concluded that a relationship exists between the clinical and epidemiological characteristics in patients with a COVID-19 diagnosis at the San Pedro Emergency Center in the Chorrillos District, Metropolitan Lima, from February to July 2021.
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Cumplimiento del protocolo para COVID-19 durante la dispensación de medicamentos a pacientes atendidos en boticas de la avenida Los Postes – San Juan de Lurigancho, febrero 2021
(Universidad Privada Norbert Wiener, 2021-10-06) Cruz Bello, Jhoselin Sommer; Pacheco Ventura, Alex; Jaramillo Briceño, Marilú Ricardina
A person has a high probability of contracting the virus if they inhale droplets released by an individual infected with COVID-19. It is therefore recommended to maintain a minimum interpersonal distance of one meter. The objective of this study was to determine the degree of compliance with the COVID-19 protocol during the dispensing of medications to patients served in pharmacies located on Avenida Los Postes in the district of San Juan de Lurigancho. The research applied an inductive method with a quantitative approach. It was classified as basic research and corresponded to a non-experimental design. The results indicated that 67.7% of the personnel correctly performed the reading of the medications prescribed in the medical prescription; 8.2% complied with checking and verifying that the medications were in good condition; 10.4% complied with providing the patients with relevant information when dispensing the medications; 72.0% complied with the correct use of face masks; 98.9% complied with delimiting the dispensing area; and 96.4% complied with providing sanitary hygiene information. In conclusion, it was determined that the degree of compliance with the COVID-19 protocol during the dispensing of medications to patients in pharmacies on Avenida Los Postes in San Juan de Lurigancho was significant, as 60.2% of the personnel adhered to the protocol.
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Determinación de nitritos y nitratos en hamburguesas de carne expendidas en el mercado Huamantanga – Puente Piedra, junio–diciembre 2019
(Universidad Privada Norbert Wiener, 2021-01-30) Navarro Agapito, Juan; Jaramillo Briceño, Marilú Ricardina
The objective of this research was to determine the content of nitrites and nitrates in the highest-demand meat hamburgers sold at the Huamantanga Market in Puente Piedra, between June and December 2019. The methodology was descriptive-comparative with a quantitative approach. 30 samples of the highest-demand meat hamburgers, acquired from stalls at the Huamantanga Market, were analyzed. The instrument used for the quantitative analysis was the UV spectrophotometer, at a wavelength of 538 nm, according to NTP-ISO 2918 ("Meat and meat products, Determination of nitrite content") and NTP-ISO 3091 ("Meat and meat products. Determination of nitrate content"). Results showed that the San Fernando brand hamburgers had an average content of 9.10 ppm for nitrites and 53.30 ppm for nitrates, while the El Gordito brand contained an average of 4.51 ppm for nitrites and 26.42 ppm for nitrates. It was concluded that the concentration of nitrites and nitrates in the highest-demand meat hamburgers sold did not exceed the values set by the Codex Alimentarius (125 ppm for nitrites and 500 ppm for nitrates), with both brands presenting values below the maximum permissible limit.
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Efectos adversos de edulcorantes no calóricos en mujeres embarazadas, 2021
(Universidad Privada Norbert Wiener, 2022-04-27) Limaymanta Yupanqui, Dennis; Escobar Escobar, Miriam; Jaramillo Briceño, Marilú Ricardina
The objective of this study was to examine the available evidence on the adverse effects of non-caloric sweeteners in pregnant women through a systematic review, applying a descriptive, cross-sectional study methodology. From a total of 184 articles, 15 were selected using the PRISMA algorithm (identification, screening, eligibility, inclusion) as the instrument. The search, which was validated by expert judgment, was conducted in databases such as PubMed, Ebsco, MedLine, Lilacs, Scielo, Scopus, and Google Scholar using the keywords "Adverse effects of non-nutritive sweeteners in pregnant women." The selected articles met the inclusion criteria and addressed the PICO question. It is concluded that the topic of non-caloric sweeteners is controversial. Therefore, the information compiled in this systematic review aims to present a panorama that helps to understand the results of studies that provide greater knowledge about the effects of non-caloric sweetener consumption during pregnancy in humans.
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Evaluación de la calidad de los envases de plástico usados en la industria farmacéutica
(Universidad Privada Norbert Wiener, 2021-08-13) Andrade Huallpa, Mercedes Belen; Jaramillo Briceño, Marilú Ricardina
This research was developed with the objective of describing the analyses performed to evaluate the quality of plastic containers used in the pharmaceutical industry. Materials and methods: This research is of a basic, descriptive, comparative, and quantitative type, with a non-experimental design based on a review of bibliographic information. The instrument was validated by three experts, and tables and graphs in Excel were used for the statistical analysis. Results: The quality characteristics of plastic containers used in the pharmaceutical industry were evaluated through dimensional analysis, functional analysis, performance analysis, and identification analysis. Conclusions: Based on the reviewed research, the majority of plastic containers used in the pharmaceutical industry comply with the required characteristics, and the analyses performed to evaluate their quality are dimensional analysis, functional analysis, performance analysis, and identification analysis.
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Factores socioeconómicos y automedicación en los pobladores de la Asociación de Vivienda Miramar de Chuquitanta – distrito San Martin de Porres – Lima Metropolitana, en el primer semestre del 2021
(Universidad Privada Norbert Wiener, 2022-04-27) Calero Cisneros, Beatriz Yolanda; Hoyos Perez, Maleni Yecit; Jaramillo Briceño, Marilú Ricardina
Self-medication is a public health problem that affects the global population and can carry potential risks, such as incorrect treatment choices, adverse drug reactions, or the masking of a serious illness with future complications. The objective of this research was to determine the relationship between socioeconomic factors and self-medication among residents of the Miramar de Chuquitanta Housing Association in the San Martín de Porres district of Metropolitan Lima, during the first half of 2021. Methodology: The research type was basic, hypothetical-deductive, with a quantitative approach, and a non-experimental, descriptive, correlational, cross-sectional, and prospective design. The sample consisted of 260 residents, and information was collected using a survey. Results: 75% of respondents self-medicated. Of these, 38.46% were adults aged 29 to 38, 42.31% were male, 36.54% had a completed secondary education, 46.54% were self-employed, 33.85% had a medium monthly income, and 50.38% reported poor health. 71.92% had knowledge of self-medication, and 70.00% considered the practice to be effective. The most frequent reasons for self-medication were economic reasons (23.46%) and difficulty accessing a medical appointment (20.38%). The most used drugs were anti-inflammatories (37.31%) and anti-influenza drugs (16.92%). Conclusion: It was determined that socioeconomic factors have a significant relationship with self-medication.
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Nivel de conocimiento de farmacovigilancia y práctica de notificación de reacciones adversas a medicamentos por el personal sanitario del Hospital de Sandia, 2021
(Universidad Privada Norbert Wiener, 2021-08-09) Pacori Huamantupa, Andy; Jaramillo Briceño, Marilú Ricardina
Pharmacovigilance is a discipline that ensures patient safety related to medication use through a set of systemic processes. However, in Peru, adverse drug reaction (ADR) reporting activities in hospitals are very limited due to a lack of knowledge about pharmacovigilance. Objective: To establish the relationship between the level of knowledge of pharmacovigilance and the practice of ADR reporting among healthcare personnel at the Sandia Hospital in 2021. Methods: This was a descriptive, correlational, prospective, and cross-sectional study with a quantitative and basic approach. A questionnaire was used for data collection, and a representative sample of 80 professionals was included. Results: The sample consisted of 12.5% doctors, 31.3% nurses, 12.5% obstetricians, 28.8% nursing technicians, and 2.5% pharmaceutical chemists and dentists, with a predominance of females at 65%. The most common age range and years of experience were 31–40 years and 1–5 years, both with 37.5%. The level of knowledge of pharmacovigilance was regular (76.3%), while the practice of ADR reporting was low (56.3%). The p-value was 0.023. Conclusion: The variables are significantly related.
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Nivel de conocimiento de la actividad antimicrobiana de la mezcla de los aceites esenciales de Dysphania ambrosioides(paico) y Mentha spicata (hierbabuena) frente a bacterias tipificadas, Huaycán – Lima, 2021
(Universidad Privada Norbert Wiener, 2023-07-22) Quispe Guzman, Nelson Martin; Jaramillo Briceño, Marilú Ricardina
The general objective was to determine the level of knowledge about the antimicrobial activity of the essential oil mixture of Dysphania ambrosioides (paico) and Mentha spicata (spearmint) against standardized bacteria in Huaycán – Lima 2021. Methodology: The deductive method was used, with a quantitative approach, basic type, and non-experimental design. The sample consisted of 100 residents who attended the Central Market No. 3 on Av. 15 de Julio A.H. Huaycán Zone J. The data collection technique was a survey, and the measurement instrument was a questionnaire. Data analysis was performed using SPSS version 26. Results: The level of knowledge about the antimicrobial activity of the essential oil mixture of paico and spearmint against Escherichia coli was at a low level for 56% of respondents, and the level of knowledge about its activity against Staphylococcus aureus was at a low level for 39% of respondents. Conclusion: It was determined that 43% of the interviewed residents had a medium level of knowledge about the antimicrobial activity of the essential oil mixture of Dysphania ambrosioides (paico) and Mentha spicata (spearmint) against standardized bacteria in Huaycán – Lima 2021.
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Nivel de conocimiento del almacenamiento domiciliario de medicamentos en los adultos mayores durante la pandemia, Callao 2021
(Universidad Privada Norbert Wiener, 2021-10-07) Berrocal Maqui, Georgina Elizabeth; Jaramillo Briceño, Marilú Ricardina
Storage is a relevant element to ensure that medicines preserve their physicochemical characteristics and maintain their therapeutic efficacy. The objective was to evaluate the level of knowledge about home storage of medicines among older adults during the pandemic, Callao 2021, in its three dimensions: temperature, humidity, and light exposure. The methodology was descriptive, applied, with a quantitative approach, non-experimental cross-sectional design, and involved the participation of 191 older adults through the application of a previously validated questionnaire via Google Forms. Results: The evaluation of the level of knowledge considering environmental conditions such as temperature, humidity, and light exposure showed the following results: the level of knowledge about the storage temperature of medicines was medium (60.2%); the level of knowledge about conservation humidity was high (50.8%); and the level of knowledge about light exposure of medicines was high (64.9%). On average, a medium level (49.7%) was found. Conclusion: The level of knowledge about home storage of medicines among the older adult population during the pandemic, Callao 2021, was medium, with 49.7%.
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Reacciones adversas asociadas al uso de anticonceptivos hormonales en usuarias que acuden a boticas Arcángel Rafael, 2021
(Universidad Privada Norbert Wiener, 2021-10-05) Barrientos Fernandez, Eusebia Docila; Gonzalo Chillihuani, Livia; Jaramillo Briceño, Marilú Ricardina
The objective of this research was to determine how adverse reactions are related to the use of hormonal contraceptives in female users visiting Arcángel Rafael Drugstores in 2021. The research methodology used a quantitative approach, with an applied type, a correlational level, and a cross-sectional non-experimental design. The population consisted of female users who purchased hormonal contraceptive products at Arcángel Rafael Drugstores from January to June 2021. The sample was a non-probabilistic convenience sample of 100 female users. Data collection was carried out using a survey technique with two questionnaires: one to measure the frequency of adverse reactions and another to determine the duration of use of hormonal contraceptives. Data analysis was performed using SPSS for both descriptive and inferential analysis. The main result was a moderate positive correlation between the two variables, with a Spearman's correlation coefficient (rho) of 0.220 and a bilateral significance level of 0.028, confirming that a significant relationship exists. It was concluded that there is a significant relationship between adverse reactions and the use of hormonal contraceptives in female users visiting Arcángel Rafael Drugstores in 2021.
Acceso abierto
Validación de aptitud del método microbiológico de recuento y microorganismos específicos para sulfametoxazol + trimetoprima en tableta recubierta
(Universidad Privada Norbert Wiener, 2020-08-05) Ysuhuailas Suárez, Elizabeth Maricarmen; Simbron De La Cruz, Marco Ernesto; Jaramillo Briceño, Marilú Ricardina
This thesis examined two combinations of active pharmaceutical ingredients that produce a synergistic antimicrobial effect against various test microorganisms. The objective was to validate the suitability of the microbiological method for microbial count and specific microorganisms in coated tablets of Sulfamethoxazole + Trimethoprim, applying both the direct inoculation and membrane filtration methods in accordance with the official standards of the United States Pharmacopeia (USP 42). The results demonstrated that the direct inoculation method, using neutralizing broth medium, was the most appropriate, as it produced more accurate and precise microbial counts across the three test batches. The results complied with the established parameters, meeting the requirements for suitability, growth promotion, and strain standardization, thus validating the microbiological test. On the other hand, the membrane filtration method yielded limited recovery due to the amount of supernatant generated by the sample when diluted with the culture medium, making it unsuitable for solid products. In conclusion, the direct inoculation method proved suitable for microbial count and specific microorganism analyses, while the membrane filtration method was not appropriate for microorganism recovery in coated tablets.