Examinando por Materia "Anticoagulants"

Mostrando 1 - 6 de 6

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Effectiveness of anticoagulation methods in the extracorporeal circuit to reduce complications in adult patients with chronic kidney failure undergoing hemodialysis
(Universidad Privada Norbert Wiener, 2019-10-20) Cisneros De La Cruz, Maria Elisvel; Casasola Condor, Cinthya Liz; Pretell Aguilar, Rosa María
Objective: Systematize the evidence on the effectiveness of anticoagulation methods in the extracorporeal circuit to reduce complications in adult patients with chronic renal failure undergoing hemodialysis. Material and Methods: The systematic review of the search has been restricted to articles with full texts, and the 10 selected articles were subjected to a critical reading, using the Grade System evaluation to identify their degree of evidence. These references were found in the following databases: Pubmed, Epistemonikos and Cochrane. The analyzes correspond: 50% systematic reviews, 30% randomized clinical trials, 10% case-control study and 10% cohort study. Having a quality of evidence that is 80% high and 20% moderate. Results: According to the results obtained in the research carried out, 60% (n = 6/10) of the evidence found indicates that the fractionated anticoagulant method is more effective than the conventional anticoagulant method. On the other hand, 30% (n=3/10) mention that both methods of anticoagulants are effective and, finally, 10% (n=1/10) mention that there is a lack of evidence/data that determines the benefit and effectiveness of anticoagulation methods in reducing complications of the extracorporeal circuit. Conclusion: 6 out of 10 evidence indicates that the fractional anticoagulation method is more effective than the conventional anticoagulation method, 3 out of 10 evidence mentions that both anticoagulation methods are effective and 1 out of 10 evidence mentions that the available data do not allow determining which methods of Anticoagulation is more effective than the extracorporeal circuit to reduce complications in adult patients with chronic renal failure undergoing hemodialysis.
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Effectiveness of high-flow central venous catheter sealing with antimicrobials and VS anticoagulants. sealing with anticoagulant in the prevention of infections
(Universidad Privada Norbert Wiener, 2020-02-22) Sosa Vilcachagua, Gladys Alicia; Avila Vargas Machuca, Jeannette Giselle
Objective: Systematize the studies found regarding the difference between sealing with antimicrobial and anticoagulant solutions vs. sealing with anticoagulant for the prevention of high-flow central venous catheter infections. Materials and Methods: the search was restricted to studies of complete accessibility, articles that in total were 10 were classified according to high and moderate quality of evidence, and/or according to the type of study. 20% correspond to meta-analysis studies, 50% to systematic reviews, both types of studies with high evidence and strength of recommendation. 50% corresponds to Spain, 20% corresponds to the US and Chile, 10% corresponds to China. Results: 50% reported that the exclusive use of antibiotics reduces the risk of high-flow catheter infection, 30% reported that the use of antibiotics plus anticoagulant not only reduces the risk of catheter infection but also prevents dysfunctional catheters. and 10% that the use of antibiotics to seal the catheter favors antibiotic resistance. Conclusions: Seals with solutions containing antibiotics and antimicrobials are more effective in preventing high flow catheter infection, but if an anticoagulant is added they are better.
Acceso abierto
Effectiveness of sealing high-flow central venous catheter with antimicrobials and anticoagulants vs sealing with anticoagulant in the prevention of infections
(Universidad Privada Norbert Wiener, 2020-02-22) Piscoya Paulino, Mariela Patricia; Sosa Vilcachagua, Gladys Alicia; Avila Vargas Machuca, Jeannette Giselle
Objective: Systematize the studies found regarding the difference between sealing with antimicrobial and anticoagulant solutions vs. sealing with anticoagulant for the prevention of high-flow central venous catheter infections. Materials and Methods: the search was restricted to studies of complete accessibility, articles that in total were 10 were classified according to high and moderate quality of evidence, and/or according to the type of study. 20% correspond to meta-analysis studies, 50% to systematic reviews, both types of studies with high evidence and strength of recommendation. 50% corresponds to Spain, 20% corresponds to the US and Chile, 10% corresponds to China. Results: 50% reported that the exclusive use of antibiotics reduces the risk of high-flow catheter infection, 30% reported that the use of antibiotics plus anticoagulant not only reduces the risk of catheter infection but also prevents dysfunctional catheters. and 10% that the use of antibiotics to seal the catheter favors antibiotic resistance. Conclusions: Seals with solutions containing antibiotics and antimicrobials are more effective in preventing high flow catheter infection, but if an anticoagulant is added they are better.
Acceso abierto
Effectiveness of unfractionated heparins versus low-molecular-weight heparins for the prevention of coagulation in patients with renal insufficiency undergoing hemodialysis.
(Universidad Privada Norbert Wiener, 2018-11-04) Rosado Gereda, Johana Lizbeth; Vicente Velasquez, Víctor Andrés; Borda Izquierdo, Alejandro
Objective: A systematic review of ten scientific articles was conducted, with a publication date of less than ten years, from the following databases: Scielo, Pubmed, Epistemonikos, Medline, and Google Scholar. Of the selected articles, 20% were systematic reviews and meta-analyses, 40% were randomized clinical trials, 20% cohort studies, and 20% case-control studies. The overall quality of evidence was high in 70% of the articles and moderate in 30%. The studies originated from the following countries: USA (30%), Canada (20%), Brazil (10%), Austria (10%), Israel (10%), Poland (10%), and the UK (10%). The GRADE system was used to identify the level of evidence. Results: According to the findings, 60% (n = 6/10) indicated that both heparins are equally effective in preventing coagulation in patients with renal failure undergoing hemodialysis. 30% (n = 3/10) suggested that low-molecular-weight heparin is more effective than unfractionated heparin, and 10% (n = 1/10) indicated that unfractionated heparin is more effective than low-molecular-weight heparin. Conclusions: Unfractionated heparin is as effective as low-molecular-weight heparin in preventing coagulation in patients with renal failure undergoing hemodialysis treatment.
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Efficacy of citrate compared to heparin in sealing catheters in patients with hemodialysis
(Universidad Privada Norbert Wiener, 2018-03-25) Peralta Rojas, María Consuelo; Lino Perez, Jhomnela Pilar; Rivera Lozada de Bonilla, Oriana
Methodology: the study was a Systematic Review of 10 articles whose search has been restricted to articles with full text, and the selected articles were subjected to critical reading, using the evaluation of the GRADE system to identify the quality of evidence and strength of recommendations . Results: The results obtained from the reviews show that of the total of 10 scientific articles reviewed, 20% (n=2/10) report that the use of citrate is effective compared to heparin, greater survival of the catheters, has a profile more favorable side effect. 60% (n=6/10) indicate that citrate and heparin are similar as anticoagulant in the sealing of catheters, the use of sodium citrate does not present clear advantages in the complications of infections compared to sodium heparin. 20% (n=2/10) report that there is no difference between citrate and heparin. Conclusion: it was concluded that heparin and citrate are effective in sealing catheters, there were no significant differences. In this sense, more comparable research studies are necessary to be able to discuss and conclude which recommendations should be transferred into clinical practice in hemodialysis.
Acceso abierto
Systematic Review on the Influence of Grapefruit Juice on the International Normalized Ratio (INR) in Anticoagulated Patients
(Universidad Privada Norbert Wiener, 2017-12-20) Vargas Machuca Vera, Luis Enrique; Melgarejo Gonzales, Marycarmen; Benites Azabache, Juan Carlos
The objective was to establish the influence of grapefruit juice on the international normalized ratio (INR) values in patients using oral anticoagulants. For the systematic review, searches were conducted in PUBMED, LILACS, ESSALUD VIRTUAL LIBRARY, and TRIPDATABASE, which evaluate the influence of grapefruit juice on INR values in patients with oral anticoagulants. A search strategy was developed using keywords, Boolean operators, truncations, among others. Fifteen original articles were found based on the inclusion criteria and risk of bias, with more than 60% adherence to the checklist developed by CASPe. Two articles were selected to carry out the systematic review. In conclusion, grapefruit juice consumption during anticoagulant treatment increases INR values, as it inhibits CYP3A4, altering the metabolism of anticoagulants, although the true clinical effect is often debated. Proper controlled studies are needed to fully determine whether a causal relationship exists.