Examinando por Materia "Enfermedad Hepática Inducida por Sustancias y Drogas"

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    Efecto hepatoprotector del extracto hidroalcohólico de las hojas de Momordica charantia L. "caigua amarga" en ratones, con intoxicación aguda hepática inducida por paracetamol
    (Universidad Privada Norbert Wiener, 2019-04-08) Quispe Toledano, Edwin; Chávez Flores, Juana Elvira
    The pharmacological study was conducted with the objective of determining the hepatoprotective effect of the hydroalcoholic extract of the leaves of Momordica charantia L. (“bitter gourd”) in mice with acute liver intoxication induced by paracetamol, and of identifying the different secondary metabolites present in the plant species through the evaluation of the qualitative phytochemical profile. Our design was experimental. For the phytochemical analysis, the leaves of Momordica charantia L. (“bitter gourd”) were collected. Subsequently, the hydroalcoholic extract was obtained by the filtration method. For the pharmacological study, the hydroalcoholic extract of the leaves of Momordica charantia L. was administered at doses of 200, 400, and 600 mg/kg in mice weighing approximately 28–32 g of body weight. The extract was administered orally for three consecutive days, and on the following day, hepatotoxicity was induced with 600 mg/kg of paracetamol. At the end, all animals were subjected to administration of pentobarbital 6.5% 0.1 mL; sacrifice was carried out by the narcosis method, the livers were isolated, and histopathological studies were performed. Results: In the phytochemical screening, the presence of chemical compounds such as alkaloids, phenolic compounds, flavonoids, and tannins was identified. In the histopathological analysis, evidence of cellular damage at the hepatic level was found in all study groups due to the hepatotoxic action of paracetamol. Conclusions: The plant species possesses secondary metabolites with biological activity. The hydroalcoholic extract of the leaves of Momordica charantia L. (“bitter gourd”), at doses of 200, 400, and 600 mg/kg, did not demonstrate hepatoprotective effect in mice with acute paracetamol-induced intoxication.