Examinando por Materia "Flavonoides"

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Actividad analgésica y antiinflamatoria del extracto hidroalcohólico de las hojas de Passiflora edulis Sims "maracuyá"
(Universidad Privada Norbert Wiener, 2019-03-06) Jalixto Alata, Sonia Carola; Salas Gutierrez, Cristina Angélica; Chávez Flores, Juana Elvira
The species Passiflora edulis Sims, or "maracuyá," is a plant that grows in northern Peru, specifically in the Lima Department, Barranca Province, Supe district, in the Venado Muerto Ravine. This study aimed to evaluate the analgesic and anti-inflammatory activity of the hydroalcoholic extract from the leaves of Passiflora edulis Sims. Methodology: A total of 56 Holtzmann strain rats of different sexes were used for the evaluation of inflammation. The rats were divided into 8 groups of seven animals. Inflammation was induced using the 0.1 mL albumin-induced plantar edema method, and the plantar volume was measured with a plethysmometer every hour for 6 hours. For the analgesic activity evaluation, the 0.8% acetic acid-induced abdominal writhing method was employed. A total of 49 Mus musculus strain mice of different sexes were divided into 7 groups of seven animals. The number of abdominal writhes was individually quantified over a 20-minute period. Results and Conclusion: The results demonstrated anti-inflammatory activity, as the 800 mg/kg hydroalcoholic extract inhibited the development of plantar edema with an effect of 100% within one hour of application, comparable to 4 mg of dexamethasone. The study also showed the analgesic activity of the 400 mg/kg hydroalcoholic extract, which achieved an effect of 70%.
Acceso abierto
Actividad antiulcerosa del extracto etanólico de las hojas de Ficus carica L. "Higo" en ratas
(Universidad Privada Norbert Wiener, 2018-09-17) Abarca Vega, Erika Victoria; Chávez Flores, Juana Elvira
Objective: To determine the antiulcer activity of the ethanolic extract of Ficus carica L. (“Fig”) leaves in rats. An ethanolic maceration of the plant leaves was carried out, followed by solubility testing, preliminary phytochemical analysis, and evaluation of antiulcer activity using the modified Lee (1971) technique at doses of 300, 600, and 800 mg/kg. A total of 60 Holtzman rats were randomly distributed into six groups, induced with gastric ulcer using naproxen 200 mg/kg, with ranitidine 30 mg/kg as the reference drug. The extract was shown to be soluble in methanol, ethanol, and distilled water. The preliminary phytochemical screening revealed the presence of flavonoids, alkaloids, phenolic compounds, and free amino groups. Regarding the antiulcer activity, the most effective treatment was the Ficus carica L. leaf extract at 800 mg/kg, achieving 83.01% inhibition of gastric ulceration, compared with ranitidine, which achieved 73.58% inhibition. These results were obtained using the Marhuenda scale. It was determined that the ethanolic extract of Ficus carica L. leaves at a dose of 800 mg/kg presents antiulcer activity in rats.
Acceso abierto
Actividad cicatrizante del extracto hidroalcohólico de las hojas de Ruellia graecizans Backer (paque-paque) en ratones albinos Mus Musculus CEPA BALB/C53
(Universidad Privada Norbert Wiener, 2020-08-13) Heredia Luis, Nuria Lissbeth; Chávez Flores, Juana Elvira
The objective of this research was to confirm the wound-healing activity of the hydroalcoholic extract from the leaves of Ruellia graecizans Backer, 'paque-paque,' in Balb/C53 strain albino mice (Mus musculus). Methodology: The plant was collected in El Rollo, Cutervo, Cajamarca, at an altitude of 1900 m.a.s.l. Solubility tests and a qualitative analysis were performed on the hydroalcoholic extract. A total of 70 mice with an average body weight of 30-40 g were distributed into seven groups. To determine wound-healing activity, gels with the extract at various concentrations (1%, 2%, 5%, and 10%) were prepared and applied to induced lesions using the method described by Vaisberg et al. (1989). These gels were compared to a standard gel and a control base gel. The results showed that the 10% gel had a healing efficacy of over 80%, comparable to the standard gel. Conclusion: The wound-healing activity of the 10% gel based on the topical application of the Ruellia graecizans Backer 'paque-paque' leaf extract was confirmed.
Acceso abierto
Actividad hipoglicemiante y evaluación de la capacidad del extracto etanólico de la semilla de Persea americana Mill "palto" para reducir el daño histológico en células β pancreáticas
(Universidad Privada Norbert Wiener, 2019-06-17) García Chávez, Yelson Néstor; Ortega Ponce, Dany Lizbeth; Chávez Flores, Juana Elvira
The objectives were to determine the hypoglycemic activity and evaluate the capacity of the ethanolic extract from the seed of Persea americana Mill, 'Palto' (avocado), to reduce histological damage in pancreatic β cells. Methodology: The ethanolic extract was obtained by collecting, chopping, and drying the seed. Maceration was performed for 7 days. The Szkudelski method was used, which induces diabetes with alloxan, and the hypoglycemic evaluation was performed using test strips. After the study concluded, the animals were sacrificed, and histological sections of the pancreas were prepared. Results: The seed extract showed solubility in water. Treatment with the 200 mg/kg dose was the most effective in reducing glucose. The histological sections showed that the damage produced by alloxan was minor in the pancreatic β cells of the mice treated with the extract of the species under study. Conclusion: The ethanolic extract of the seed was successfully obtained and the solubility test was performed. The extract applied in mice presents hypoglycemic activity via the Szkudelski method, and it was determined that the seed extract has the capacity to reduce histological damage in pancreatic β cells.
Acceso abierto
Efecto cicatrizante del gel a base del extracto etanólico del fruto de Vallea stipularis L.f “chuillur” en ratas Holtzman
(Universidad Privada Norbert Wiener, 2025-04-08) Flores Heredia, Rosario Ysabel; Chávez Flores, Juana Elvira
La presente investigación, titulada: “Efecto reparador del gel a base del extracto etanólico del fruto de Vallea stipularis L.f. 'chuillur' en ratas Holtzman”, tuvo como propósito principal verificar la capacidad reparadora del gel formulado con el extracto etanólico del fruto de Vallea stipularis L.f. “chuillur” en ratas de la línea Holtzman. Metodología: Se empleó un enfoque analítico con perspectiva cuantitativa, clasificándose como una investigación de tipo aplicada con diseño experimental. La muestra incluyó ratas Holtzman y el material vegetal considerado fue el fruto de Vallea stipularis L.f. “chuillur”. A partir del fruto, se preparó un extracto etanólico a 70°, seguido de pruebas de solubilidad y análisis cualitativo preliminar. Luego, se elaboró un gel en concentraciones del 0,5; 5 y 10% para evaluar su efecto reparador mediante una técnica de segunda intención, registrando los datos a través de una ficha estandarizada. Resultados: El extracto presentó solubilidad en agua, etanol y metanol. Entre los metabolitos identificados se encontraron flavonoides, compuestos fenólicos y taninos, así como grupos amino libres, triterpenos y esteroides. El gel producido mostró propiedades organolépticas satisfactorias y una estabilidad física adecuada. La actividad cicatrizante fue más notable en las concentraciones de 5 y 10%, evidenciando una regeneración homogénea con un mayor grosor dérmico a través de la formación de capas celulares. Además, se observaron gránulos de queratohialina junto con una unión dermoepidérmica extensa, formación de tejido conectivo y fibras de colágeno. Conclusión: Se verificó que el gel elaborado a base del extracto etanólico del fruto de Vallea stipularis L.f. "chuillur" al 5 y 10% posee un efecto reparador superior al estándar tópico.
Acceso abierto
Estudio botánico, fitoquímico y farmacológico de la actividad cicatrizante de Morus alba L. (mora o morera blanca)
(Universidad Privada Norbert Wiener, 2017-07-11) Cano Kriete, Tania Zulema; Cano Pérez, Carlos Alfredo
The present research encompasses the botanical, phytochemical, and pharmacological study of the wound-healing activity of white mulberry Morus alba Link. In the botanical study, the internal structures of white mulberry (Morus alba) were analyzed through histological sections of the root, stem, and leaves. In the phytochemical study, the powdered sample was used for the hydroalcoholic maceration of white mulberry leaves. Through a phytochemical screening, the chemical compounds of white mulberry were identified. In the pharmacological study, it was ultimately determined that the cream formulated with the dry extract of white mulberry leaves (Morus alba) exhibits wound-healing activity with a therapeutic efficacy percentage similar to other treatments administered topically to albino mice. This pharmacological activity is possibly due to the presence of flavonoids and tannins.
Acceso abierto
Estudio del extracto etanólico de los rizomas de Curcuma longa L. “Cúrcuma” y su actividad antioxidante
(Universidad Privada Norbert Wiener, 2019-03-08) Aliaga Palomares, Ana María; Muñoz Suárez, Liliana Sofía; López Parra, Ronal Rosendo
Objective: To determine the phytoconstituents present in the rhizome of Curcuma longa L. “turmeric” and its antioxidant activity. Materials and Methods: The study was quasi-experimental, descriptive, and cross-sectional. The study species was collected in the district of Kimbiri, Province of La Convención, Cusco. An ethanolic extraction of the dried turmeric rhizomes was carried out in order to perform the qualitative phytochemical analysis, following the methodology proposed by Olga Lock de Ugaz, to determine the phytoconstituents. Dilutions of the dry extract were prepared at concentrations of 5%, 10%, and 20%. Antioxidant activity was evaluated using the DPPH assay (1,1-diphenyl-2-picrylhydrazyl), and the absorption band was measured at 517 nm with a UV-Visible spectrophotometer. These results were analyzed with the statistical software IBM SPSS Statistics version 24.0 and Microsoft Excel 2016. Results: The presence of secondary metabolites such as phenolic compounds, flavonoids, quinones, and coumarins was determined. The antioxidant activity results are presented as the mean inhibition percentage of the ethanolic extract at 5%, 10%, and 20%, which were 81.552%, 82.077%, and 83.742%, respectively, compared with the standard sample of Vitamin C, which showed means corresponding to 5%, 10%, and 20% of 96.258%, 93.313%, and 84.110%, respectively. Conclusion: It was determined that the ethanolic extract of the rhizomes of Curcuma longa L. “turmeric” exhibits antioxidant activity comparable to that of Vitamin C and may be considered a source of natural antioxidants. This activity is attributed to the presence of phenolic compounds and flavonoids.
Acceso abierto
Influencia de la ingesta de flavonoides sobre el riesgo de desarrollar cáncer colorrectal en adultos.
(Universidad Privada Norbert Wiener, 2022-05-30) Hamasaki Matos, Angie Joyce; Bohórquez Medina, Andrea Lisbet
El cáncer colorrectal está clasificado como el tercer cáncer más común y el segundo más mortal en el mundo y componentes dietarios pueden ser factores protectores. Por ello, el presente trabajo académico tiene como objetivo evaluar evidencia actualizada mediante un comentario crítico clínico acerca de la influencia del consumo de flavonoides en la disminución del riesgo de desarrollar cáncer colorrectal en adultos. Para ello, se trabajó en base a las cinco etapas de la NuBE y a través de la herramienta CASPe se procedió a clasificar los artículos científicos según su grado de evidencia. del proceso de revisión y evaluación se seleccionó el artículo Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies. El estudio estructura, describe y analiza la data de manera pertinente para el tipo de estudio que los autores realizan. El análisis estadístico es presentado de manera concisa y precisa lo que permitiría replicar el estudio. la discusión planteada por los autores resalta los principales hallazgos y los pone en contexto comparándolos con trabajos similares anteriormente publicados. Por último, se puede concluir que es necesario generar más evidencia científica de alto nivel que permita extrapolar resultados a la población en general.
Acceso abierto
Revisión critíca: influencia del consumo de flavonoides en el cancer de higado
(Universidad Privada Norbert Wiener, 2021-02-03) Pasco Rosado, Patricia del Carmen; Lozada Urbano, Michelle Fatima
El cáncer de hígado es el sexto tipo de cáncer con mayor índice de mortalidad, siendo el carcinoma hepatocelular el más común representando el 90% de todos los casos, el cual se origina en las células llamadas hepatocitos. La presente investigación secundaria titulada revisión crítica: Influencia del consumo de flavonoides en el cáncer de hígado, planteó como objetivo determinar la influencia del consumo de flavonoides en el cáncer de hígado. La pregunta clínica fue: ¿Cómo influye el consumo de flavonoides en pacientes con afecciones hepáticas y cáncer de hígado? Se utilizó la metodología Nutrición Basada en Evidencia (NuBE). La búsqueda de información se realizó en Pubmed, Scielo, Wiley, Science Direct, Google scholar y Taylor & Francis, encontrando 52 artículos, siendo seleccionados 23 que han sido evaluados por la herramienta para lectura crítica CASPE, seleccionándose finalmente el artículo titulado como Autofagia: un objetivo terapéutico potencial de los polifenoles en el carcinoma hepatocelular, el cual posee un nivel de evidencia A II y grado de recomendación fuerte, de acuerdo a la expertise del investigador. El comentario crítico permitió concluir que los flavonoides tienen efectos antioxidantes, antiinflamatorios, inactivadores de carcinógenos, antiproliferativos, inductores de la detención del ciclo celular, apoptóticos, antiangiogénicos, moduladores de la autofagia y reversión de múltiples fármacos, además, ayudan a prevenir y tratar varios tipos de cáncer incluidos el carcinoma hepatocelular.