Examinando por Materia "Hipoglucemiantes"

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Acceso abierto
Actividad hipoglicemiante y evaluación de la capacidad del extracto etanólico de la semilla de Persea americana Mill "palto" para reducir el daño histológico en células β pancreáticas
(Universidad Privada Norbert Wiener, 2019-06-17) García Chávez, Yelson Néstor; Ortega Ponce, Dany Lizbeth; Chávez Flores, Juana Elvira
The objectives were to determine the hypoglycemic activity and evaluate the capacity of the ethanolic extract from the seed of Persea americana Mill, 'Palto' (avocado), to reduce histological damage in pancreatic β cells. Methodology: The ethanolic extract was obtained by collecting, chopping, and drying the seed. Maceration was performed for 7 days. The Szkudelski method was used, which induces diabetes with alloxan, and the hypoglycemic evaluation was performed using test strips. After the study concluded, the animals were sacrificed, and histological sections of the pancreas were prepared. Results: The seed extract showed solubility in water. Treatment with the 200 mg/kg dose was the most effective in reducing glucose. The histological sections showed that the damage produced by alloxan was minor in the pancreatic β cells of the mice treated with the extract of the species under study. Conclusion: The ethanolic extract of the seed was successfully obtained and the solubility test was performed. The extract applied in mice presents hypoglycemic activity via the Szkudelski method, and it was determined that the seed extract has the capacity to reduce histological damage in pancreatic β cells.
Acceso abierto
Comparación del efecto hipoglucemiante del extracto hidroalcohólico de las hojas Smallanthus Sonchifolius (Poepp) Rob “yacón“ frente a un extracto de libre comercio, en ratones hiperglucémicos
(Universidad Privada Norbert Wiener, 2015) Bello Sánchez, Vanessa Jaqueline; Inche Cabello, Jorge Alberto; Torres Veliz, Ernesto Raúl
The hypoglycemic effect of the hydroalcoholic extract of Smallanthus sonchifolius (Poepp.) H. Rob. (“yacón”) leaves and of a commercially available extract was evaluated on blood glucose levels in male and female mice, both normoglycemic and with hyperglycemia induced by oral glucose overload and alloxan, in order to assess their possible hypoglycemic activity. Blood glucose measurements were taken after fasting at 0, 2, 4, 6, and 24 hours. The analysis of results showed that administration of the hydroalcoholic extract of Smallanthus sonchifolius leaves and of the commercial extract in normoglycemic mice did not produce a statistically significant decrease (p > 0.05) in blood glucose levels; only glibenclamide exhibited this effect at 24 hours. In hyperglycemic mice with oral glucose overload, a statistically significant decrease (p < 0.05) in blood glucose levels was observed with administration of both extracts at 6 hours after the initial measurement. Similarly, in alloxan-induced hyperglycemic mice, a statistically significant decrease (p < 0.05) in blood glucose levels was observed 6 hours after treatment. It is concluded that the extract of Smallanthus sonchifolius leaves and the commercial preparation exhibit hypoglycemic activity under induced hyperglycemia, but do not present hypoglycemic effects under normoglycemic conditions.
Acceso abierto
Efecto de la caigua (Cyclanthera pedata) en personas con diabetes tipo 2 del exfundo Santa Rosa de Lurín, 2012
(Universidad Privada Norbert Wiener, 2013) Charqui Figueroa, Maritza Sheylam; Parreño Tipián, Juan Manuel
A study was conducted on the efficacy of caigua (Cyclanthera pedata) in patients with type 2 diabetes mellitus, with the aim of reducing hyperglycemia levels. The participants were residents of the former Santa Rosa estate (in the district of Lurín) who presented with this disease. This population, due to its engagement in pig farming and the sale of high-fat products, is at high risk of developing other chronic diseases (cardiovascular risk, retinopathy, diabetic nephropathy, etc.). The study included 350 people. Treatment was administered to 37 of them, duly diagnosed with type 2 diabetes mellitus by medical staff. Biochemical determination of glycemia was performed using the enzymatic method, and the Student’s t-test and the Kolmogorov test were applied as statistical methods. For the treatment with caigua, a dose of 20 g in the form of salad was administered once a week for a period of 3 months. At the end of this period, it was observed that the 37 patients included in the study showed a decrease in glucose levels. Laboratory determinations before and after were 142.78 mg/dL and 85.15 mg/dL, respectively. As a control group, 5 patients who abandoned the treatment due to work and other activities were considered. Their glucose levels were measured before and after, showing no decrease when compared to those who adhered to the caigua treatment.
Acceso abierto
Elaboración de una bebida de arándano y efecto de su consumo sobre la glucosa sérica
(Universidad Privada Norbert Wiener, 2021-05-12) Gamarra Espinoza, Gino Francesco; Espinoza Rado, Erika Paola
La presente investigación secundaria titulada como revisión crítica: Efecto del consumo de fructosa en niveles de ácido úrico plasmático en sujetos con posibilidad de enfermedad metabólica, tuvo como objetivo evaluar el efecto de la ingesta de fructosa en los niveles de ácido úrico plasmático en sujetos con posibilidad de enfermedad metabólica. La pregunta clínica fue: ¿El consumo de fructosa ejercerá efecto sobre los niveles de ácido úrico plasmático en sujetos con posibilidad de enfermedad metabólica? Se utilizó la metodología Nutrición Basada en Evidencia (NuBE). La búsqueda de información se realizó en Science Direct, Pubmed, Scielo, Bvs encontrando 17 artículos, siendo seleccionados 12 que han sido evaluados por la herramienta para lectura crítica CASPe, seleccionándose finalmente el Ensayo Clínico Aleatorizado titulado como Postprandial metabolic effects of fructose and glucose in type 1 diabetes patients: a pilot randomized crossover clinical trial, el cual posee un nivel de evidencia A1 y Grado de Recomendación Fuerte, de acuerdo a la expertise del investigador. El comentario crítico permitió concluir que la ingesta de fructosa aumenta las concentraciones de ácido úrico plasmático en pacientes con posibilidad de enfermedad metabólica.
Acceso abierto
Evaluación del efecto hipoglicemiante del extracto etanólico de las hojas de Vallesia dichotoma Ruiz & Pav. "cun cun" en ratones
(Universidad Privada Norbert Wiener, 2022-08-17) Cano Agramonte, Kenyi Ricardo; Chávez Flores, Juana Elvira
The objective was to evaluate the hypoglycemic effect of the ethanolic extract from the leaves of Vallesia dichotoma Ruiz & Pav., 'cun cun,' in mice. Methodology: The plant was collected in the La Primavera human settlement, Piura. A solubility test and a qualitative analysis were performed on the 'cun cun' leaves. A total of 48 mice of the Balbin/C53/CNPB strain were used, with an average body weight between 30–40 g. They were assigned to six groups of eight individuals. The first group was the control, the second was a Glibenclamide standard (5 mg/kg), and the third, fourth, and fifth groups were extracts at concentrations of 50, 100, and 150 mg/kg, all administered orally. Diabetes was induced with Alloxan at 75 mg/kg via intraperitoneal injection. Results: The ethanolic extract was found to be soluble in polar solvents (distilled water, ethanol, and methanol) and to contain flavonoids, phenolic compounds, steroids and/or triterpenes, and alkaloids. The extract at concentrations of 100 and 150 mg/kg had a hypoglycemic effect (p-value < 0.05). Conclusion: The hypoglycemic effect of the ethanolic extract from the leaves of Vallesia dichotoma Ruiz & Pav., 'cun cun,' was confirmed at the 100 mg/kg concentration.
Acceso abierto
Nivel de conocimiento de la acción hipoglucemiante del rambutan (Nephelium lappaceun L.) y uso como terapia complementaria de los pacientes de la botica Capricornio, distrito de San Martin de Porres – Lima, 2022
(Universidad Privada Norbert Wiener, 2022-07-08) Astuhuamán Chávez, Kinverlin Estela; Fernández Huerta de Martínez, Miuren Yvett Catherine; Guadalupe Sifuentes de Posadas, Luz Fabiola
Rambutan is an exotic fruit from Malaysia that is cultivated in the central Peruvian jungle. Metabolites with hypoglycemic activity have been found in its seed and peel. Objective: This study aimed to determine the level of knowledge of the hypoglycemic action of rambutan (Nephelium lappaceum L.) and its use as a complementary therapy for type 2 diabetes among patients of the Capricornio drugstore in the San Martín de Porres district, Lima, in 2022. Methodology: The design was non-experimental, descriptive, cross-sectional, and correlational in scope. A validated data collection instrument was used on a sample of 220 patients who visited the Capricornio drugstore. Results: Positive results were obtained for the four specific hypotheses proposed, so the alternative hypothesis was accepted and the null hypothesis was rejected. Conclusions: The evaluation of patients at the Capricornio drugstore concluded that as knowledge of rambutan's hypoglycemic action increases, the use of complementary therapy also increases, thus confirming the general hypothesis of the study.
Acceso abierto
Problemas relacionados a las nuevas moléculas en pacientes ambulatorios con diabetes mellitus tipo 2, según la clasificación del Segundo Consenso de Granada en la Clínica Internacional; enero 2015–marzo 2017
(Universidad Privada Norbert Wiener, 2019-01-31) Chávez Taype, Katherine; Buitron Arenaza, Rossillo Vanessa; Caldas Herrera, Emma
The objective of this study was to identify drug-related problems (DRPs) associated with new molecules in outpatients with type 2 diabetes mellitus, according to the classification of the Second Granada Consensus, at Clínica Internacional between January 2015 and March 2017. A descriptive, retrospective, and longitudinal study was conducted, with a population of 359 patients and a sample of 172 patients over 35 years of age. Clinical records were reviewed, with emphasis on those receiving treatment with new molecules (Kombiglyze, Onglyza, Trayenta, Toujeo, Jardiance, Victoza, Forxiga, Tresiba), prescribed by the Endocrinology Department. A DRP Identification Form was used to achieve the study objectives. Through pharmacotherapeutic follow-up, a total of 441 DRPs were identified, of which 58.7% (259) corresponded to male patients and 41.3% (182) to female patients. Potential DRPs accounted for 68.9% (304) and actual DRPs for 31.1% (137). Regarding the subtypes of DRPs, those related to necessity (DRP1) represented 15% (66), those related to effectiveness (DRP3) accounted for 5% (22), those related to safety (DRP5) represented 78% (346), and DRP6 accounted for 2% (7).