Examinando por Materia "Latent Tuberculosis"

Mostrando 1 - 3 de 3

Acceso abierto
Effectiveness of a treatment regimen including bedaquiline for bacteriological conversion at six months in patients with multidrug-resistant tuberculosis
(Universidad Privada Norbert Wiener, 2018-08-26) Lizano Ochoa, Silvia; Zubieta Rosales, Rosa Eliana; Bonilla Asalde, César Antonio
Objective: Systematize the evidence on the effectiveness of the treatment scheme that includes bedaquiline for bacteriological conversion at the sixth month in patients with multidrug-resistant tuberculosis. Materials and Methods: Systematic, observational and retrospective review that synthesizes the results of multiple primary investigations. They are an essential part of evidence-based nursing due to their rigorous methodology, identifying relevant studies to answer specific questions of clinical practice, the search has been restricted to articles with full text, and the selected articles were subjected to critical reading. using the grade system to assign recommendation strength. In the final selection, 10 international research articles were chosen, where we found that 20% (02) corresponds to Italy, 20% (02) South Africa, with 10% (1) France, Belarus, England, China, Canada, India. These were found in the Pubmed database. Among the high evidence articles we find 50% of the countries of India, Canada, China, Italy and England. And with 50% moderate evidence to France, Italy, Belarus, South Africa Results: 100% of the reviewed articles (n=10/10) show that bedaquiline has the potential to achieve high sputum culture conversion rates at the sixth month of treatment in patients with tuberculosis.
Acceso abierto
Effectiveness of isoniazid therapy compared to other therapies in treating latent tuberculosis infection
(Universidad Privada Norbert Wiener, 2019-12-14) Torres Hilario, Zenovia Elena; Sánchez Parinango, Eva María; Pérez Siguas, Rosa Eva
Objective: Systematize the evidence on the effectiveness of Isoniazid therapy in comparison with other therapies for the treatment of latent tuberculosis infection. Material and Methods: It is a systematic review, the articles were subjected to a critical review of the literature, using the Grade evaluation system, thus recognizing the degree of evidence, these studies were found in the databases: PubMed, Science direct, Cochrane , Epistemonikos. Of the 10 articles found, 40% (n= 4/10) are systematic reviews, 10% (n=1/10) are meta-analyses, 30% (n= 3/10) are randomized controlled trials and 20 % (n= 2/10) are a cohort study. Furthermore, these articles come from the USA (60%), followed by Canada (20%), then Australia (10%) and Spain (10%). Results: It was found that 100% (n=10/10) indicate that isoniazid preventive therapy for 6 months is as effective as other therapies for the treatment of infection with latent tuberculosis, however, all other therapies for being shorter showed greater adherence and fewer adverse effects compared to 6 months of isoniazid. Conclusion: The majority of the articles reviewed (10/10) report that isoniazid preventive therapy for 6 months is as effective as other therapies for the treatment of infection with latent tuberculosis, however, the other shorter therapies show greater adherence and fewer adverse effects.
Acceso abierto
Interferon gamma and hematological biomarkers in patients with latent tuberculosis infection care at a health center in Lima - Peru 2020
(Universidad Privada Norbert Wiener, 2023-12-03) Quispe Huamaní, Ross Mery Lady; Astete Medrano, Delia Jessica
Currently, a quarter of the world's population is infected with the Koch bacillus but shows no symptoms. This condition is called latent tuberculosis infection. Objective: To determine the relationship between gamma interferon and hematological biomarkers in patients with latent tuberculosis infection treated at a health center in Lima, Peru, in 2020. Method and Design: Observational, cross-sectional, and correlational study. Results from 133 patients who underwent the QFT-Plus test between January and February 2020 and their hemograms were collected. Additionally, 20 patients with active TB were included as controls. Results: Hemograms of patients with ILTB (33.8%) were compared, finding a statistically significant finding with a p-value < 0.036 in the lymphocytes of male patients with ILTB. Conclusions: Gamma interferon is only related to the absolute lymphocyte count parameter in male patients. Further research is needed to identify other hematological indicators that help differentiate the status or progression of ILTB patients.