Examinando por Materia "Oenothera"

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    PublicaciónAcceso abierto
    Estudio de estabilidad de las formulaciones crema y gel elaborados con la fracción polar del extracto alcohólico de las hojas de Oenothera rosea L´Her. ex Aiton "chupasangre"
    (Universidad Privada Norbert Wiener, 2018-06-09) Bellodas Castillo, Ronald Martín; Cano Salvador, Fanny Chris; Nué Martinez, Jorge Jonathan
    This study conducted an accelerated stability study of two semi-solid pharmaceutical formulations—cream and gel—prepared with the polar fraction of the alcoholic extract from the leaves of Oenothera rosea L'Her. ex Aiton, "Chupasangre." The Peruvian regulations in force, according to Ministerial Resolution (R.M.) 805-2009-MINSA, were used for this study, evaluating the organoleptic characteristics (appearance, color, odor), viscosity, pH, the quantification of flavonoids as an indicator of extract concentration, and the microbial limit, based on climatic zone IVa. The results of the accelerated stability study for both pharmaceutical forms demonstrate that both products maintained the microbiological quality parameters. However, for the physicochemical parameters, only the cream showed conservation within the product specifications, while the gel suffered degradation at the end of the study.
  • Miniatura
    PublicaciónAcceso abierto
    Evaluación del perfil de seguridad de irritación dérmica in vitro mediante el método HET-CAM. y actividad cicatrizante de formulaciones magistrales elaboradas con el extracto hidroalcohólico de las hojas de chupasangre (Oenothera rosea Ait.)
    (Universidad Privada Norbert Wiener, 2021-11-09) Suárez Becerra, Ronal Elgar; Manyari Pérez, Lizeth Judith; Cárdenas Orihuela, Robert Armando
    The objective of this study was to evaluate the dermal irritation safety profile in vitro using the HET-CAM method and the wound-healing activity of magistral formulations prepared with the hydroalcoholic extract from the leaves of Oenothera rosea Ait. ('Chupa Sangre'). This was done through an experimental prospective method, developed in the laboratory of the Faculty of Pharmacy and Biochemistry at Wiener University. Method: The HET-CAM method was employed to evaluate irritant activity, and incised wounds on albino rats were used to determine wound-healing activity. The presence of secondary metabolites was determined in the plant species. Gels at concentrations of 1% and 0.5% were prepared, demonstrating that they are mild irritants (I.I. 2.66 and 4.38). For the wound-healing activity, four working groups, each consisting of 8 rats, were formed. The results demonstrated that the 0.5% and 1% concentrations presented good wound-healing performance; however, the positive control achieved better healing. Conclusion: The hydroalcoholic extract from the leaves of Oenothera rosea Ait., 'Chupa Sangre,' presents a good safety profile and wound-healing activity.