Introduction: Iron deficiency anemia is a public health problem that affects a high percentage of children under 5 years of age worldwide. This condition is characterized by a deficiency of iron in the blood, which can cause various symptoms such as fatigue, pallor, shortness of breath and learning disabilities. Objective: "To determine how knowledge about anemia is related to adherence to treatment in mothers of children under 5 years of age with iron deficiency anemia who are seen in the pediatrics service". Methodology: Our research will employ an applied methodology, using a quantitative approach and a nonexperimental cross-sectional design. We will collect data from 109 mothers of children under 5 years of age by administering two questionnaires, one indigenous and one universal, which have been validated and tested as reliable. Once the questionnaires are completed, the data will be collected, coded and recorded in a data matrix. Statistical analysis will be performed using SPSS 26.0 software, employing both descriptive and inferential techniques. Spearman's Rho test will be used to validate and verify the hypotheses of the study, allowing us to draw accurate conclusions about the measurement of variables.