Critical review: perioperative immunomodulatory enteral nutrition in patients with gastric cancer.

Abstract

The fifth most common neoplasm in Latin America is gastric cancer, which unfortunately compromises the absorption of nutrients and negatively impacts the immune system. The objective of this research was to carry out a critical review on whether enteral nutrition through the perioperative immunomodulatory diet will be beneficial in patients with gastric cancer. The Evidence-Based Nutrition (NuBE) methodology was used. The information search was carried out in Science Direct, Pubmed, Springer, 13 articles were selected that have been evaluated by the “Critical Appraisal Skills Program Spain Caspe” tool for critical reading, where finally a systematic review and meta-analysis titled as Impact of Preoperative Immunomodulatory Nutrition in Outcomes of Patients Undergoing Surgery for Gastrointestinal Cancer, a Systematic Review and Meta-analysis, which has a level of evidence A I and a Strong recommendation grade, according to the researcher's expertise. The critical commentary allowed us to conclude that immunomodulatory enteral nutrition is beneficial in patients with gastric cancer and that there is sufficient evidence to answer this question.

Se ha reportado que la deficiencia sérica de vitamina D se asocia de forma significativa a malos resultados en infecciones respiratorias agudas (incidencia y severidad). Sin embargo, los resultados y desenlaces de la suplementación con vitamina D en ensayos clínicos han sido heterogéneos. La búsqueda de información se realizó en las base de datos Medline y Cochrane, encontrando 20 artículos sobre el tema, siendo seleccionados 8 artículos que fueron evaluados por la herramienta para lectura crítica CASPE, seleccionándose finalmente el ensayo clínico titulado como: “High Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial”, la cual posee un nivel de evidencia I y grado de recomendación Fuerte, de acuerdo a la expertise del investigador. El comentario crítico permitió concluir que la suplementación con 100,000 UI de vitamina D mensual durante 12 meses redujo la incidencia de infecciones respiratorias agudas en la población intervenida.