Anti-inflammatory effect of Funica Granatum L. in patients with cardiovascular disease

Abstract

Over the last few years, researchers have been studying certain phytochemicals present in different foods and their beneficial effect on people's health; polyphenols being one of the most investigated types of phytochemicals. The “Punica granatum” pomegranate has polyphenols such as: ellagic acid, punicalagin, among the most important; They have been studied in different non-communicable conical diseases such as cardiovascular diseases and cancer. In the present secondary research titled as Critical Review: Anti-inflammatory effect of Punica granatum in patients with cardiovascular disease; whose objective was to know the effect of pomegranate consumption on pro-inflammatory biomarkers, serum lipid levels and blood pressure levels. The clinical question was: Would the consumption of pomegranate (Punica Granatum L.) or its bioactive components produce anti-inflammatory effects in patients with cardiovascular disease? The evidence-based nutrition (NuBE) methodology was used. The search of the scientific literature was carried out in Spanish and English. The databases consulted were SCOPUS, WOS, PUBMED/MEDLINE AND EMBASED. 28 articles were found and 9 were selected, for which the CASPe tool was used. The selected study was “The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: A meta-analysis and systematic review”. The critical commentary revealed that the consumption of substances derived from pomegranate could help reduce inflammatory biomarkers, as well as serum lipid levels and blood pressure. Future studies are necessary to establish a recommended dose, as a complementary aid to pharmacological treatment.

El paciente con Enfermedad Pulmonar Obstructiva Crónica (EPOC), presenta un deterioro en el estado nutricional, calidad de vida, parámetros respiratorios .La presente investigación secundaria titulada como revisión crítica: Impacto de la intervención nutricional con omega 3 en pacientes con EPOC: tuvo como objetivo identificar el posible impacto de la intervención nutricional con el omega 3 en pacientes con EPOC La pregunta clínica fue: ¿ La intervención nutricional basada en dietas con ácidos grasos omega 3 disminuirá la sintomatología respiratoria y estado nutricional del paciente adulto que padece de EPOC? Se utilizó la metodología Nutrición Basada en Evidencia (NuBE). La búsqueda de información se realizó en PUBMED, SCIELO, SCIENCE DIRECT, encontrando 30 artículos, siendo seleccionados 9 que han sido evaluados por la herramienta para lectura crítica CASPE, seleccionándose finalmente el Ensayo Clínico Aleatorizado titulado como Exploración de metabolitos de ácidos grasos poliinsaturados n-6 y n-3 asociados con niveles nutricionales en pacientes con enfermedad pulmonar obstructiva crónica estable grave, el cual posee un nivel de evidencia AII y Grado de Recomendación Fuerte, según lo evaluado por la investigadora. El comentario crítico permitió concluir que dicho estudio clínico, sugiere un impacto del consumo de ácidos grasos poliinsaturados omega 3 y omega 6 sobre la progresión de la enfermedad, nutrición, calidad de vida y parámetros respiratorios en los pacientes con Enfermedad Pulmonar Obstructiva Crónica (EPOC).