Critical review: relationship between serum vitamin D levels and breast cancer risk.

Abstract

Breast cancer is currently the cancer that affects women with the highest prevalence, positioning itself as the type of cancer with the highest mortality rate worldwide. On the other hand, vitamin D is one of the micronutrients with various fundamental metabolic and physiological functions in some organs of the human body, such as the liver, heart, lungs, intestines, bones, and mammary glands, where it acts as a vitamin receptor. D (VDR). In addition, it exerts immunomodulatory and antiproliferative effects, therefore, evidence-based research is required to analyze the importance of this vitamin in the prevention, development, as well as treatment of breast cancer. By virtue of the above, the present research: “critical review: Relationship between serum levels of vitamin D and the risk of breast cancer”, aimed to identify the relationship between serum levels of vitamin D and the risk of breast cancer. . Therefore, the following research question was asked: “Are low levels of vitamin D related to an increased risk of breast cancer in adult women?” The search for scientific articles was carried out in five scientific bases, SCOPUS, PUBMED, EMBASE, WEB OF SCIENCE, SCIENCE DIRECT. 121 articles were found, of which 23 were selected by carrying out the evaluation, and selection of the article for the critical comment, which is a systematic review and meta-analysis titled: “Vitamin D and breast cancer: A systematic review and meta-analysis of observational studies”, with the highest level of evidence and recommendation (I and I respectively). After analyzing the selected article, by writing the critical comment, it can be concluded that 25 (OH) D deficiency was directly related to breast cancer and that sun exposure can help prevent breast cancer. more efficient than ingesting it through food supplements.

Se utilizó la metodología Nutrición Basada en Evidencia (NuBE) para el desarrollo del presente trabajo. La búsqueda de información se realizó en Medline y Cochrane, encontrando 62 artículos, siendo seleccionados 6 que han sido evaluados por la herramienta para lectura crítica CASPE. El comentario crítico permitió concluir que la suplementación de 3 g de ácidos grasos omega-3 de origen marino no mejoró los indicadores nutricionales y desenlaces clínicos en este grupo de pacientes adultos con cáncer colorrectal.