Effectiveness of induced hypothermia in neuroprotection of the newborn with hypoxic-ischemic encephalopathy.

Abstract

Objective: To systematize and evidence the efficacy of kidney transplantation in the reduction of the risk of graft loss for survival in pediatric patients. Materials and Methods: The study is quantitative, with a systematic review design. The population consisted of 39 articles that were reviewed, and 10 scientific articles were selected as the sample. Of these, 20% (n=2/10) were systematic reviews, 10% (n=1/10) were systematic review and meta-analysis, and 70% (n=7/10) were cohort studies. According to the quality of evidence, 30% was rated as high and 70% as moderate. In terms of the strength of recommendations, 30% were strong and 70% were weak, based on the country where the research was conducted. Results: The reviewed articles show that 40% (n=4/10) indicate the efficacy of renal replacement therapy in the risk of graft loss for survival in pediatric patients. Another 40% (n=4/10) state that it is partially effective, and 20% (n=2/10) state it is not effective. Conclusion: It is concluded that 40% (n=4/10) indicates that renal replacement therapy is partially effective in the risk of graft loss for survival in pediatric patients.

Revisión Sistemática observacional y retrospectivo, en la selección definitiva se eligieron 10 artículos y revisiones sistemáticas y meta análisis, el 20% (02) corresponden a Uruguay, con un 20% (02) a Canadá, igualmente con un 20% (02) a China, con un 10% (01) a Australia, con un 10% (01) Argentina, Con un 10% (01) Inglaterra y un 10% (01) a Brasil respectivamente. Resultados: De artículos y revisiones sistemáticas analizados el 100% afirma que la hipotermia inducida es eficaz en la neuro protección del recién nacido con HIE. En la reducción del riesgo de muerte o discapacidad importante del desarrollo neurológico con un porcentaje del 100%. La hipotermia redujo el riesgo de muerte o discapacidad mayor del neurodesarrollo a los 18 meses en recién nacidos HIE moderada y HIE grave se expresa en un 30 % y un aumento en la tasa de supervivencia con función neurológica normal en un 100% Conclusiones: Se evidenció en las investigaciones revisadas que existe eficacia de la hipotermia inducida en la neuroprotección del recién nacido con HIE. Se mostró eficacia en cuanto a reducción del riesgo de muerte en recién nacidos con esta patología y disminución de los daños neurológicos post terapia de hipotermia inducida.