Examinando por Materia "Probiotics"

Mostrando 1 - 20 de 31

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Benefits of probiotics in colorectal cancer
(Universidad Privada Norbert Wiener, 2020-12-16) Cotrina Barrios, Leidy Brighity; Dávila Córdova, Jennifer Estefania
The present secondary research entitled as a critical review: “Benefits of probiotics in colorectal cancer”, aimed to identify the benefits of probiotics in patients with colorectal cancer. The clinical question was: Will probiotics produce benefits in adults over 50 years of age who suffer from colorectal cancer? The Evidence-Based Nutrition (NuBE) methodology was used. The information search was carried out in PubMed, Scielo, HINARI and LILACS, finding 31 articles, 5 being selected that have been evaluated by the CASPE critical reading tool, finally selecting the Prospective Controlled Clinical Trial titled “Usage of Probiotics and its Clinical Significance at Surgically Treated Patients Suffering from Colorectal carcinoma” which has a level of evidence I and Grade of Recommendation I, according to the expertise of the researcher. The critical comment allowed us to conclude that there are great benefits of probiotics, since by regulating the intestinal microbiota, they have a positive impact on the health of the patient with colorectal cancer, both at the digestive and extra-digestive levels.
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Critical Review: Effect of Probiotic Consumption on Reducing Insulin Resistance in People with Type 2 Diabetes
(Universidad Privada Norbert Wiener, 2021-07-12) Alzamora Perez, Isis Marinet; Bohórquez Medina, Andrea Lisbet
In the present investigation, the clinical question was answered: Will probiotic supplementation be effective in reducing insulin resistance in adult patients aged 18 to 75 years with type 2 diabetes? The Evidence-Based Nutrition (NuBE) methodology was used. The information search was carried out in PUBMED, MEDLINE, SCIENCE DIRECT, finding 19 articles, 7 being selected that have been evaluated by the CASPE critical reading tool, finally selecting the systematic review article titled "Effects of probiotics in diabetes mellitus type 2: a meta-analysis”, which has a level of evidence AII and Grade of Strong Recommendation, according to the expertise of the researcher. The critical commentary allowed us to conclude that probiotics can have an effect on reducing insulin resistance by improving the insulin resistance index (HOMA-IR).
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Critical review: effect of probiotic supplementation in adult patients with diabetes mellitus II
(Universidad Privada Norbert Wiener, 2022-12-13) Laguna Sánchez, Judith; Inocente Camones, Miguel Angel
Type II Diabetes Mellitus is one of the most prevalent non-communicable diseases worldwide. An appropriate nutritional intervention contributes to mitigating the progression of this chronic disease. This research, titled 'Critical Review: Effect of Probiotic Supplementation in Adult Patients with Type II Diabetes Mellitus,' aimed to identify the benefits of probiotic supplementation in adult patients with Type II Diabetes Mellitus. The Evidence-Based Nutrition (NuBE) methodology was used. Information was searched in PUBMED, COCHRANE, SCIENCE DIRECT, PLOS ONE, DIALNET, and EBSCO, finding 47 articles, of which 9 were selected and evaluated using the CASPE critical reading tool. The randomized clinical trial titled 'Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled study' was chosen, as it has a level of evidence I and a strong recommendation grade. The study concluded that multi-strain probiotic supplementation has beneficial effects on glycemic control in patients with Type 2 Diabetes, particularly in HbA1c levels, making probiotic supplementation a potential complementary treatment for metabolic control of Type 2 Diabetes.
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Critical review: effect of probiotic therapy (lactobacillus) in the treatment of helicobacter pylori
(Universidad Privada Norbert Wiener, 2022-10-07) Montejo Berrios, Marilyn Laura; Bohórquez Medina, Andrea Lisbet
The present investigation seeks to know if supplementation with Lactobacillus improves the treatment of Helicobacter pylori. The applied methodology is based on Evidence-Based Nutrition, for this a search was carried out in databases such as Scopus, Embase, Pubmed/MEDLINE and WOS. After the reading process, 17 articles were selected for evaluation with the CASPE critical reading tool. Finally, according to the level of evidence and degree of recommendation reached, the article “Efficacy of Lactobacillus-supplemented triple therapy for H. pylori eradication: A meta-analysis of randomized controlled trials” was chosen, which according to the evaluation reached a Strong AI level of evidence and recommendation. Through the development of the critical commentary, it is possible to conclude that the use of Lactobacillus improves the eradication rate of Helicobacter pylori and reduces the adverse effects of the treatment. pharmacological triple therapy in this infection.
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Critical review: effect of supplementation with probiotics, prebiotics and/or synbiotics on inflammation in adults with chronic kidney disease
(Universidad Privada Norbert Wiener, 2023-12-05) Pariona Ortega, Delcy Alcira; Bohórquez Medina, Andrea Lisbet
Systemic inflammation and alteration of the intestinal microbiota play an important role in the progression of Chronic Kidney Disease and morbidity and mortality, for this reason the present secondary research entitled “Critical review: effect of supplementation with probiotics, prebiotics and/or "symbiotics in inflammation in adults with chronic kidney disease", aimed to clarify the effect of supplementation with biotics on inflammatory markers in adult patients with chronic kidney disease. Chronic Kidney. The Evidence-Based Nutrition (NuBE) methodology was used. The information search was carried out in databases such as Science Direct, Pubmed (MeSH), Embase, Scopus and Scielo. As a result of this search, 13 articles were selected that were evaluated with the CASPE critical reading tool. For this critical review, the systematic review and meta-analysis titled “Effect of probiotics, prebiotics and synbiotics on uremic toxins, inflammation and oxidative stress in patients on hemodialysis” was chosen, which has a level of evidence AI and grade of evidence STRONG. . The critical review allows us to conclude that supplementation with these biotics helps reduce CRP and IL-6 levels in patients on hemodialysis.
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Critical review: effect of the use of probiotics as a supplement in patients with Alzheimer's
(Universidad Privada Norbert Wiener, 2024-07-11) Cervera Alarcon, Romy Claude; Espinoza Rado, Erika Paola
Alzheimer's AD as a pathology is a degenerative alteration of the central nervous system, which determines a loss of knowledge and reduced cognitive function. Patients with Alzheimer's are at serious risk of developing protein and energy malnutrition, which is associated with increased morbidity and mortality. Some alterations can affect the nutritional status of patients with Alzheimer's, which includes loss of autonomy, disorientation, eating disorders, weight loss and frequent ambulatory activities, and this would lead to progression in the disease. The present review aims to collect information on the use of Probiotics as a supplement in patients diagnosed with Alzheimer's. The clinical question was: What is the effect of using Probiotics through supplements in patients with Alzheimer's? An evidence-based nutrition (NuBE) approach was used. After searching databases such as PUBMED, SCIELO, SCOPUS, SCIENCE DIRECT, 13 articles were found, of which 9 were selected to be evaluated by the CASPE critical reading tool, the selected research was the Randomized Clinical Trial RCT Effect of Probiotics Bifidobacterium Breva in Improving Cognitive Function and Preventing Brain Atrophy in Elderly Patients With Suspected Mild Cognitive Impairment: Results of a Randomized, Double-Blind Study of 24 weeks (PREADVISE) which has a level of evidence AI and Grade of Recommendation I. The critical comment; This study included tests for the timely detection of mild cognitive impairment (MCI) and dementia such as ADAS-jcog and MMSE, which had a positive correlation with respect to supplementation with B. breve MCC1274 in preventing the progression of brain atrophy. After 24 weeks of supplementation, it gives us a broad overview of the nutritional intervention, this research was supported by other results; observational and prospective studies that suggest that the use of Probiotics improves mild cognitive function and the incidence of AD; Likewise, these studies are based more on the benefits of the intestinal microbiota and its relationship with mild cognitive impairment (MCI) and dementia.
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Critical Review: Effects of prebiotics, probiotics and/or synbiotics to improve the intestinal microbiota and the levels of nitrogenous products in patients with CKD.
(Universidad Privada Norbert Wiener, 2022-05-05) Chumpitazi Alcantara, Cynthia Leonor; Dávila Córdova, Jennifer Estefania
Nutritional intervention in patients with CKD to slow the progression of kidney disease has been little studied. However, today more studies are being conducted to generate additional options for patient benefit. The present secondary research, titled Critical Review: Effects of Prebiotics, Probiotics, and Synbiotics to Improve Gut Microbiota and Nitrogenous Product Levels in Patients with CKD, aimed to identify articles that answer the clinical question: Will nutritional intervention with prebiotics, probiotics, and synbiotics improve gut microbiota and nitrogenous product levels in adults with CKD, with or without dialysis? The methodology used was Evidence-Based Nutrition (EBN). Information was searched in PUBMED, MEDLINE, SCIELO, using the CASPE critical reading tool. The final selection was the Randomized Clinical Trial titled Synbiotics Relieving Renal Failure by Improving Gut Microbiology (SYNERGY): A Randomized Trial, which has an A2 level of evidence and a Strong Recommendation Grade, according to the researcher's expertise. The critical commentary concluded that synbiotic therapy helps reduce a specific uremic toxin in patients with CKD and helps regulate gut microbiota.
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Critical review: efficacy of probiotic use for the prevention and control of diarrhea in cancer patients undergoing chemotherapy
(Universidad Privada Norbert Wiener, 2024-07-04) Gómez La Rosa, Jose Antonio Jesús; Bohórquez Medina, Andrea Lisbet
Chemotherapy-induced diarrhea (CID) is a common gastrointestinal adverse reaction after chemotherapy and radiation therapy, negatively affecting the quality of life of cancer patients. Many clinical and preclinical studies show that chemotherapy significantly alters the gut microbiota. Numerous bacteria, called probiotics, have been identified as protectors against tumor genesis. Given their ability to preserve intestinal homeostasis, probiotics have been shown to have a beneficial effect on the appearance and/or severity of diarrhea and also play a protective role against cancer development. This research, titled "Critical Review: Efficacy of Probiotics in Preventing and Controlling Diarrhea in Cancer Patients Undergoing Chemotherapy," aimed to investigate whether probiotics are effective in preventing and controlling diarrhea in cancer patients undergoing chemotherapy.
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Critical review: nutritional intervention with probiotics in patients with dyslipidemia
(Universidad Privada Norbert Wiener, 2023-01-19) Urcuhuaranga Reyes, Wendy Rosario; Dávila Córdova, Jennifer Estefania
The present secondary research titled as a critical review: Nutritional intervention with probiotics in patients with dyslipidemia, aimed to identify the effects of probiotics on the lipid profile in patients with dyslipidemia. The clinical question was: Will nutritional intervention with probiotics improve the lipid profile in adults suffering from dyslipidemia? The Evidence-Based Nutrition (NuBE) methodology was used. An information search was carried out in PubMed, Lilacs, Scielo, Dialnet, Science Direct and 37 articles were found, of which 11 were selected and evaluated by the CASPE critical reading tool, finally selecting the Systematic Review and Meta-analysis titled “The impact of probiotic yogurt consumption on lipid profiles in subjects with mild to moderate hypercholesterolemia: A systematic review and meta-analysis of randomized controlled trials”, which has a level of evidence A II and Grade of Recommendation Strong, according to the researcher's expertise. The critical comment allowed us to conclude that daily consumption of 300 mg of probiotic yogurt, with a maximum dose of 109 cfu and for more than 4 weeks reduces total cholesterol and LDL-C.
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Critical review: nutritional intervention with probiotics to improve the health of adult patients with Type 2 Diabetes Mellitus with comorbidities
(Universidad Privada Norbert Wiener, 2022-11-29) Revilla Peláez, Milagros Elizabeth; Bohórquez Medina, Sofia Lorena
The current secondary research is called critical review: nutritional intervention with probiotics to improve the health of adult type 2 diabetic patients, aimed to determine the Nutritional intervention with probiotic supplements to improve health status (effect on inflammatory markers and homeostasis of glucose) of adult patients with type 2 diabetes mellitus. The clinical question was: Will nutritional intervention with probiotic supplements improve health status (effect on inflammatory markers and glucose homeostasis) of adult patients with type 2 diabetes mellitus? To evaluate articles, the NuBE methodology (Evidence-Based Nutrition methodology) was used. The databases used in the search for articles were: Pubmed/MEDLINE, Science direct, WOS and SCOPUS, where 37 articles were found, 10 were selected that have been evaluated by the CASPE critical reading tool, finally selecting the Randomized Clinical Trial. titled as “Effects of probiotic supplementation on inflammatory markers and glucose homeostasis in adults with type 2 Diabetes Mellitus: Systematic review.”, which has a level of evidence A I and Grade of Strong Recommendation, according to the expertise of the researcher. The critical comment allowed us to conclude that there is sufficient evidence to affirm the beneficial effect of nutritional intervention with probiotics to improve the health of adult type 2 diabetic patients with comorbidities.
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Critical review: probiotic supplementation in the management of overweight or obese patients
(Universidad Privada Norbert Wiener, 2023-01-26) Champa Gonzales, María Julia; Bohórquez Medina, Sofia Lorena
The secondary research titled 'Probiotic Supplementation for the Management of Overweight or Obese Patients' aimed to determine the effect of probiotic supplementation in managing overweight or obese adult patients. The clinical question was: What effect does probiotic supplementation have on managing overweight or obese patients? The Evidence-Based Nutrition (NuBE) methodology was used. Information was searched in PUBMED, SCIELO, and SCIENCE DIRECT, finding 35 articles. After filtering, 16 were selected and evaluated using the CASPE critical reading tool. Finally, a systematic review and meta-analysis of randomized controlled trials titled 'Effects of probiotics on body adiposity and cardiovascular risk markers in overweight and obese individuals' was chosen, possessing an AI level of evidence and a strong recommendation grade. The critical commentary concluded that probiotic supplementation has a modest beneficial effect on body weight and adiposity in overweight and obese individuals, suggesting a potential complementary therapeutic approach.
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Critical review: the effect of glutamine-probiotic supplementation on intestinal permeability of surgical patients with gastrointestinal cancer
(Universidad Privada Norbert Wiener, 2022-03-25) Lo Tayraco, Jessica Alexandra; Bohórquez Medina, Andrea Lisbet
The present secondary research titled as a critical review: The effect of glutamine or probiotic supplementation on the intestinal permeability of surgical patients with gastrointestinal cancer, aimed to determine the effect of glutamine or probiotic supplementation on the intestinal permeability of surgical patients with gastrointestinal cancer. The clinical question was: What is the effect of glutamine or probiotic supplementation on intestinal permeability in surgical patients with gastrointestinal cancer? The Evidence-Based Nutrition (NuBE) methodology was used. An information search was carried out in PUBMED, SCOPUS, SCIENCE DIRECT, where 47 articles were found, of which 5 were selected to be evaluated by the CASPE Critical Reading Tool, finally selecting the Randomized Clinical Trial titled “Addition of probiotics to glutamine therapy as intestinal barrier protection for severe surgical patients”, which has a level of evidence AI and Strong Recommendation Grade, according to the researcher's experience. The critical commentary concluded that the simultaneous administration of probiotics and glutamine has a synergistic and protective effect on intestinal barrier function and in reducing intestinal permeability.
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Effect of probiotic supplementation during pregnancy and maternal-infant health
(Universidad Privada Norbert Wiener, 2022-11-08) Cano Rafael, Yessel; Bohórquez Medina, Andrea Lisbet
The present secondary research titled as a critical review: Effect of probiotic supplementation during pregnancy and maternal-child health, aimed to identify scientific articles of clinical studies related to the topic of Probiotic supplementation during pregnancy and exclusive breastfeeding in neonates. The clinical question was: Can nutritional supplementation with probiotics (Lactobacillus rhamnosuscepa GG and bifidobacteria) in pregnant and lactating mothers improve the health of the mother and newborn? The Evidence-Based Nutrition (NuBE) methodology was used. The information search was carried out in PUBMED, SCIELO, SCIENCE DIRECT, finding 156 articles, 16 being selected that have been evaluated by the CASPE critical reading tool, finally selecting a systematic review titled: Effect of probiotic supplementation in pregnant women: A meta-analysis of randomized controlled trials, which has a level of evidence AII and Grade of Strong Recommendation, according to the expertise of the researcher. The critical comment allowed us to conclude that there is evidence which allows us to affirm the beneficial effect of probiotic supplementation in pregnant women and neonates, which improves the transmission of said probiotic strains, improving the immune response in relation to pathologies, benefiting both.
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Effect of the use of probiotics (lactobacillus rhamnosus and bifidobacterium longum) in the prevention and control of intestinal dysbiosis. Systematic review.
(Universidad Privada Norbert Wiener, 2018-09-24) Vega Bazán, Dayana Joyanne; Bohórquez Medina, Andrea Lisbet
Objective: To determine the effect of probiotics (lactobacillus and Bifidobacterium) for the prevention and treatment of intestinal dysbiosis in adults. Materials and methods: Systematic review, based on the PRISMA statement and Cochrane Rob 2.0 collaboration. A systematic search was conducted in the databases Scopus, Web of Science, Embase, etc. Ten studies were selected for the final sample. The search strategy was 'Probiotics/intestinal dysbiosis/Clinical uses/Risk and safety/lactobacillus rhamnosus/bifidobacterium longum/Use therapeutic/Gut microbiome.' Results: Of the 10 articles, 9 mentioned probiotic treatments for the symptoms of intestinal dysbiosis (IBS and its subtypes), 2 of the 9 trials included FOS (inulin) in their probiotic composition, and 1 article focused on the treatment against diarrhea caused by Clostridium difficile. Seven out of 10 studies showed significant improvements in abdominal pain, abdominal distension, and intestinal permeability (p<0.01; p<0.01; p=0.01), respectively. Conclusion: The use of probiotics, specifically Lactobacillus rhamnosus and Bifidobacterium longum, used in 9 of 10 analyzed articles, reported a significant reduction (p<0.05) in the clinical symptoms typical of intestinal dysbiosis and also showed a preventive effect in individuals with an unaltered microbiota.
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Effect of the use of probiotics in the management of stress and depression in adults
(Universidad Privada Norbert Wiener, 2022-04-28) Uriarte Sánchez, Edward Josehp; Bohórquez Medina, Andrea Lisbet
Probiotics are live microorganisms that provide health benefits. Depression is a very common pathology that could cause emotional as well as physical problems. Recent research has shown a significant bidirectional communication called the gut-brain axis, as well as a relationship between the alteration of the enteric microbiome and psychiatric disorders, which would allow for further studies and the proposal of alternative therapies. The clinical question was: What is the effect of using probiotics in managing stress and depression in adults? The information search was carried out in PUBMED, SCOPUS, SCIENCE DIRECT, and EMBASE, finding 150 articles, of which 21 were selected and evaluated by the CASPE critical reading tool, selecting the Randomized Clinical Trial: “Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota”, which has a level of evidence I and Grade of Recommendation I, according to the researcher's expertise. The critical commentary concluded that the use of probiotics to alleviate depressive symptoms is promising, mainly due to their potential anti-inflammatory effect, but additional double-blind randomized clinical trials and more rigorous studies are needed to support such conclusions.
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Effectiveness of probiotics in preventing and controlling antibiotic-induced diarrhea and Clostridium difficile in pediatric patients
(Universidad Privada Norbert Wiener, 2018-12-12) Palma Barrera, Ines Rosario; Millones Gómez, Segundo Germán
Systematic review of 10 scientific articles selected from databases such as Cochrane, LILACS, Scielo, Medline and Pubmed; They were analyzed according to the GRADE scale; resulting in 70% (n=7/10) indicating that probiotics are effective in the prevention and control of diarrhea due to antibiotics and Clostridium difficile in pediatric patients. 60% reduce the risk of developing diarrheal diseases associated with C. difficile. The probiotics S. boulardii and Lactobscyllus rhamnosus are effective in preventing diarrhea due to antibiotics compared to placebos in hospitalized pediatric patients. It is concluded that 7 of 10 reviewed articles show the effectiveness of probiotics for the prevention and control of diarrhea due to antibiotics and Clostridium difficile in pediatric patients.
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Effectiveness of probiotics in reducing uremic toxins in patients with chronic kidney disease
(Universidad Privada Norbert Wiener, 2019-11-17) Vargas Marcaquispe, Dina; Ibarra Noreña, Haydeé; Pretell Aguilar, Rosa María
OBJECTIVE: Systematize evidence on the effectiveness of probiotics in reducing uremic toxins in patients with chronic kidney disease. MATERIAL AND METHOD: The study is quantitative, with a systematic, observational and retrospective review design; of articles with full text, which identified their grade or quality of evidence according to the Grade System. Likewise, the population was made up of 10 articles that were obtained from the database. Of which 70% are of systematic review design and 30% of randomized clinical trials. RESULTS: Of the 10 articles reviewed, (10/10), 100% demonstrate the effectiveness of probiotics in reducing uremic toxins in patients with chronic kidney disease. CONCLUSIONS: 10 of the 10 articles respond that probiotics are effective in reducing uremic toxins in patients with chronic kidney disease (CKD); helping to slow the progression of kidney disease and improve heart health, as an adjuvant therapy for CKD, because they cost less and are more acceptable in kidney patients.
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Effectiveness of the use of probiotics for the prevention of necrotizing enterocolitis and mortality in preterm infants
(Universidad Privada Norbert Wiener, 2018-07-08) Martin Flores, Dina Isabel; Rondón Zorrilla, Susy Zulema; Perez Siguas, Rosa Eva
Objective: To systematically analyze the evidence on the efficacy of probiotics for the prevention of necrotizing enterocolitis and mortality in preterm newborns. Material and method: Eleven scientific articles on the efficacy of probiotics for the prevention of necrotizing enterocolitis and mortality in preterm newborns were found in the databases Cochrane, Scielo, Lilacs, and Medline/Pubmed. A systematic review was applied, analyzing the studies using the GRADE scale to verify their strength and quality of evidence. Of the 11 articles reviewed, 36% (4/11) correspond to the methodological design of systematic reviews, 55% (6/11) are meta-analyses, and 9% (1/11) is a systematic review and meta-analysis. Results: 82% (9/11) demonstrate the efficacy of probiotics for the prevention of necrotizing enterocolitis and mortality in preterm newborns, and 18% (2/11) show that probiotics prevent only necrotizing enterocolitis. Conclusions: From the 11 articles reviewed, the efficacy of probiotics for the prevention of necrotizing enterocolitis and mortality in preterm newborns is evidenced.
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Efficacy of Probiotics for the Prevention of Diarrhea in Cancer Patients Undergoing Chemoradiation
(Universidad Privada Norbert Wiener, 2019-09-22) Jimenez Barrenechea, Marcia Maricruz; Quispe Lucana, Gianina Raquel; Matta Solis, Eduardo Percy
Objective: Systematize the evidence regarding the effectiveness of probiotics for the prevention of diarrhea in cancer patients undergoing chemoradiation. Materials and Methods: The design used was a retrospective and observational systematic review, which uses a specific method to summarize and synthesize the results of scientific articles. The population was made up of 19 scientific articles whose publication was in scientific databases. Selection criteria were established such as age, degree and quality of evidence, etc., through which 10 articles that represent the sample were selected. Results: In the 10 selected articles, 30% (n=3) were carried out in China, 10% (n=1) in the United Kingdom, 10% (n=1) in Canada, 10% (n=1) in Spain , 10%(n=1) in Slovakia, 10% (n=1) in Germany, 10%(n=1) in Scotland and 10%(n=1) in Thailand. Of which 30% (n=3) were Systematic Review studies, 30% (n=3) Meta-analysis and systematic review, 40% (n=4) Randomized Controlled Trial. Of 10 pieces of evidence, 100% (n=10) affirm that probiotics prevent diarrhea in cancer patients undergoing chemoradiation. Conclusions: There is high-quality evidence on the effectiveness of probiotics in preventing diarrhea in cancer patients undergoing chemoradiation.
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Efficacy of the use of probiotics for the prevention of necrotizing enterocolitis and mortality in premature newborns.
(Universidad Privada Norbert Wiener, 2018-07-08) Martin Flores, Dina Isabel; Rondón Zorrilla, Susy Zulema; Perez Siguas, Rosa Eva
Objective: Systematize the evidence on the effectiveness of oral lactoferrin for the prevention of necrotizing enterocolitis and sepsis in preterm newborns. Materials and Methods: This systematic review consists of 10 scientific articles found on the effectiveness of oral lactoferrin for the prevention of necrotizing enterocolitis and sepsis in preterm newborns, found in the following databases: Lipecs, Lillacs, Scielo, Chrocane, Medline, and Pubmed. Among the evidence, we found experimental research designs, meta-analyses, and systematic reviews, with the articles published in Spanish and English, and no older than ten years. Results: Of the 10 articles reviewed, 90% (9/10) show that the administration of oral lactoferrin in preterm newborns, with very low birth weight and neonates, decreases late-onset sepsis and necrotizing enterocolitis. 10% (1/10) does not show the effectiveness of oral lactoferrin in preterm newborns. Conclusion: The effectiveness of oral lactoferrin for the prevention of necrotizing enterocolitis and sepsis in preterm newborns is evident.