Examinando por Materia "Sepsis"

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Digital morphometry and positional parameters of monocytes in patients with sepsis in the laboratory of a level III-1 hospital in Lima, January - June 2024
(Universidad Privada Norbert Wiener, 2023-12-03) Ramos Rojas, Mady Canelú; Avelino Callupe, Paul Fortunato
In sepsis, monocyte numbers increase, resulting in monocytosis, which is morphologically evident as enlarged cells with vacuoles and finer chromatin in peripheral smear analysis. However, some alterations are undetectable through microscopic observation, requiring novel methods like digital image processing. This method enhances information retrieval by allowing the scientific visualization of numerous digital images, enabling the study of hematological alterations related to specific diseases.
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Effectiveness of activating a sepsis code to reduce in-hospital mortality in patients with severe sepsis/septic shock
(Universidad Privada Norbert Wiener, 2020-08-02) Loayza Goicochea, Oscar Roger; Pretell Aguilar, Rosa María
Objective: Systematize the available evidence on the effectiveness of activating a sepsis code to reduce in-hospital mortality in patients with severe sepsis/septic shock. MATERIALS AND METHODS: The type of research is quantitative, the design is a systematic review of 10 articles that were obtained from the following databases: Pubmed, Biomedcentral, Sciencedirect, Medintensiva, Scielo. Of the 10 articles reviewed and analyzed, 50% (n= 5/10) are Quasi-experimental, 40% (n= 4/10) Cohort and 10% (n=1/10) are systematic reviews. According to the quality of the evidence, it was found to be 90% moderate and 10% high. According to the recommendation strength it is 90% weak and 10% strong. According to the country where the investigations were carried out, they correspond to Spain 70%, the United States 20% and Cuba 10%. Results: According to the review, it is evident that 100% of the articles (n = 10/10) indicate that the implementation of the sepsis code is effective in reducing in-hospital mortality in patients with severe sepsis and septic shock. Conclusion: It is concluded that 10 of 10 evidence reviewed and analyzed demonstrate that the activation of a sepsis code is effective in reducing in-hospital mortality in patients with severe sepsis/septic shock.
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Effectiveness of early administration of antibiotic therapy to decrease mortality in patients with severe sepsis in emergency.
(Universidad Privada Norbert Wiener, 2021-03-07) Causillas Acevedo, Fraxides; Medina Julon, Luz Anita; Uturunco Vera, Milagros Lizbeth
Introduction: According to the World Health Organization (WHO), approximately 31 million people suffer from an episode of sepsis each year. Of these, approximately 6 million people die from sepsis. In low- and middle-income countries, the burden of sepsis is higher and represents one of the main causes of maternal and neonatal death. (5) In Peru, there are no systematized national epidemiological data on morbidity and mortality associated with sepsis. In primary studies carried out in different hospitals in Peru, it was determined that the mortality rate associated with sepsis varies from 25.3% to 40%, increasing according to the risk factors associated with each population studied.(6)
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Effectiveness of early goal-directed therapy compared to usual care to reduce mortality in patients with severe sepsis in critical units
(Universidad Privada Norbert Wiener, 2019-12-01) Méndez Altamirano, Iraida; Jáuregui Mendoza, Javier Enrique; Bonilla Asalde, César Antonio
Objective: Systematize evidence on the effectiveness of early goal-directed therapy compared to usual care to reduce mortality in patients with severe sepsis in critical units. Material and Methods: retrospective, quantitative observational systematic review, subject to critical analysis, using the Grade evaluation system, located in the database: Sciencedirect, PubMed, Researchgate, Epistemonikos and Scielo. Of 10 articles selected and systematically reviewed, 100% are of high quality as described: 90% are meta-analysis, 10% are systematic review. The results of the systematic review carried out in the research are from the countries of China, Italy, Iran, Korea and the United States. Results: Of the evidence found, 70% indicate that early goal-directed therapy is more effective than usual care in reducing mortality in patients with severe sepsis in critical units while 30% indicate the opposite. Conclusions: In 7 of the 10 articles reviewed it is evident that early goal-directed therapy is effective in reducing mortality in patients with severe sepsis in critical units. On the other hand, 3 of the 10 articles reviewed point out the opposite.
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Effectiveness of early goal-directed therapy versus usual care to reduce mortality in patients with severe sepsis
(Universidad Privada Norbert Wiener, 2019-02-17) Ramírez Carrasco, Aydeé; Vergara Guerra, Cynthia; Remuzgo Artezano, Anika
Material and Methods: Systematic observational and retrospective review, with critical reading and using the GRADE evaluation method in order to identify the degree of evidence of the articles published in several databases: Scielo, PubMed, Sciencedirect, Epistemonikos, Researchgate. Of the 10 articles systematically reviewed: 90% (n= 9/10) are meta-analyses, 10% (n= 1/10) are randomized controlled trials and were carried out in the countries of China (40%), then the United States. United States (20%), England (20%), Italy (10%) and Iran (10%). Results: 60% indicate that early goal-directed therapy is similar in effectiveness to usual care in reducing mortality in patients with severe sepsis. 40% indicate that early goal-directed therapy is more effective than usual care in reducing mortality in cases of severe sepsis. Conclusion: Early goal-directed therapy has similar efficacy to usual care in reducing mortality in cases of severe sepsis.
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Effectiveness of oral lactoferrin for the prevention of necrotizing enterocolitis and sepsis in preterm infants.
(Universidad Privada Norbert Wiener, 2018-07-08) Alcántara Segovia, Julie Stefany; Quispe Quispe, Luzmila Elvira; Pretell Aguilar, Rosa Maria
Objective: Systematize the evidence on the effectiveness of oral lactoferrin for the prevention of necrotizing enterocolitis and sepsis in preterm newborns. Materials and Methods: This systematic review consists of 10 scientific articles found on the effectiveness of oral lactoferrin for the prevention of necrotizing enterocolitis and sepsis in preterm newborns, found in the following databases: Lipecs, Lillacs, Scielo, Chrocane, Medline, and Pubmed. Among the evidence, we found experimental research designs, meta-analyses, and systematic reviews, with the articles published in Spanish and English, and no older than ten years. Results: Of the 10 articles reviewed, 90% (9/10) show that the administration of oral lactoferrin in preterm newborns, with very low birth weight and neonates, decreases late-onset sepsis and necrotizing enterocolitis. 10% (1/10) does not show the effectiveness of oral lactoferrin in preterm newborns. Conclusion: The effectiveness of oral lactoferrin for the prevention of necrotizing enterocolitis and sepsis in preterm newborns is evident.
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Effectiveness of oral lactoferrin for the prevention of necrotizing enterocolitis and sepsis in preterm newborns.
(Universidad Privada Norbert Wiener, 2018-07-08) Quispe Quispe, Luzmila Elvira; Pretell Aguilar, Rosa Maria
Objective: To systematize the evidence on the effectiveness of oral lactoferrin for the prevention of necrotizing enterocolitis and sepsis in preterm newborns. Materials and Methods: This systematic review consists of 10 scientific articles found on the effectiveness of oral lactoferrin for the prevention of necrotizing enterocolitis and sepsis in preterm newborns. The articles were found in the following databases: Lipecs, Lillacs, Scielo, Chrocane, Medline, and Pubmed. The evidence found includes experimental research designs, meta-analyses, and systematic reviews. The articles are published in Spanish and English, with no more than ten years of age. Results: Of the 10 articles reviewed, 90% (9/10) show that the administration of oral lactoferrin in very low birth weight preterm newborns decreases late-onset sepsis and necrotizing enterocolitis. And 10% (1/10) does not show the effectiveness of oral lactoferrin in preterm newborns. Conclusions: The effectiveness of oral lactoferrin for the prevention of necrotizing enterocolitis and sepsis in preterm newborns is evident.
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Effectiveness of the antimicrobial-impregnated central venous catheter to prevent bloodstream infections in critical care patients
(Universidad Privada Norbert Wiener, 2018-12-16) Ramirez Espinoza, Leslie Massiel; Vera Escorza, Delia; Uturunco Vera, Milagros Lizbeth
Objective: Systematize the evidence on the effectiveness of the central venous catheter impregnated with antimicrobials to prevent bloodstream infection in patients in critical units. Material and Methods: Systematic observational and retrospective review, subjected to critical reading and using the GRADE evaluation system to identify the degree of evidence of the articles published in the following databases: PubMed, Epistemonikos, Sciencedirect, Scielo, Researchgate. Of the 10 articles systematically reviewed, 50% (n= 5/10) are meta-analyses, 30% (n= 3/10) are randomized controlled trials, and 20% (n= 2/10) are cohort studies. and come from the countries of England (30%), the United States (20%), followed by China (10%), Malaysia (10%), Brazil (10%), Holland (10%), and Spain (10%).Results: 100% (n=10/10) (15,16,17,18,19,20,21,22,23,24) indicate that the central venous catheter impregnated with antimicrobials is effective for prevent bloodstream infection in patients in critical units. Conclusion: The study concludes that the central venous catheter impregnated with antimicrobials is effective in preventing bloodstream infection in patients in critical units. Because the nurse is in constant vigil, supervision, prevention in care and security.
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Efficacy of central venous catheters impregnated with antiseptics and/or anti-bacterials for the prevention of bloodstream infections in patients across different services
(Universidad Privada Norbert Wiener, 2018-07-07) Cajo Luque, Carla Roxana; Castro Lecca, Jose Luis; Gamarra Bustillos, Carlos
Objectives: Determine the effectiveness of the central venous catheter impregnated with antiseptics and/or antimicrobials in preventing bloodstream infections in patients. Methodology: The systematic review of the 9 scientific articles found on the effectiveness of the central venous catheter impregnated with antiseptics and/or antimicrobials in the prevention of bloodstream infections in patients, were found in the following databases Cochrane, Lilacs, Scielo , Medline Pubmed, all of them were analyzed according to the Grade scale to determine their strength and quality of evidence. Results: Of the 9 articles reviewed, 56% (5/9) show the effectiveness of the central venous catheter impregnated with antiseptics and/or antimicrobials in preventing blood flow. While 33% (3/9) show that it is not effective, 11% (1/9) are indifferent to the study carried out. Conclusions: Of the 9 articles reviewed, 56% (5/9) show the effectiveness of the central venous catheter impregnated with antiseptics and/or antimicrobials in preventing blood flow.
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Efficacy of the bundle in reducing mortality in patients with severe sepsis in critical units.
(Universidad Privada Norbert Wiener, 2018-07-08) Poma Suarez, Rosa Elena; Carranza Manco, Alexis Armando; Glenni Garay, Zarely Zabeli
"Systematic review, subjected to critical reading and using the GRADE evaluation system to identify the level of evidence of articles published in the following databases: PubMed, Sciencedirect, Redalyc, Scielo, Researchgate, Epistemonikos. Of the 10 articles systematically reviewed, 20% (n=2/10) are systematic reviews, 10% (n=2/10) are meta-analyses, and 70% (n=7/10) are cohort studies, originating from the countries of the United States (20%), Brazil (20%), China (20%), followed by Italy (10%), Australia (10%), France (10%), and the Netherlands (10%). 100% (n=10/10) indicate that the bundle is effective in reducing mortality in patients with sepsis in critical care units. Conclusion: The bundle is effective in reducing mortality in patients with sepsis in critical care units."
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Efficacy of the need to use an adequate strategy for the identification of a patient with sepsis in the prehospital setting.
(Universidad Privada Norbert Wiener, 2021-01-06) Tello Rodriguez, Iris Nadia; Torres Arce, Fiorella Geraldinne; Matta Solis, Hernan Hugo
Objective: Analyze and systematize the evidence on the effectiveness of the need for an appropriate strategy to identify patients with sepsis in the prehospital environment. Materials and Methods: Systematic, observational, and retrospective review of a quantitative type, subjected to critical selection, using the GRADE evaluation system to identify the degree of evidence, found in the following databases: Sciencedirect, Pubmed, Dialnet, Redalyc, Scielo, Cochrane, Researchgate, Elsevier, Wiley Online Library, EBSCO, Epistemonikos. Of the 10 articles systematically reviewed, 90% are of high quality, as described below: 60% (n= 6/10) are systematic reviews, 10% (n= 1/10) are randomized controlled trials, and 30% (n= 3/10) are cohort studies. According to the results of the systematic review carried out in this study, the studies come from the United Kingdom (40%), followed by Australia (10%), England (10%), USA (10%), Germany (10%), Canada (10%), and the Netherlands (10%). Results: Additionally, of the evidence found, 90% (n= 9/10) indicate that it would be effective to have an appropriate strategy for identifying sepsis patients in the prehospital environment. Conclusion: An appropriate and effective strategy is necessary to identify sepsis patients in the prehospital environment.
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Efficacy of the use of adhesives with chlorhexidine for central venous catheters, in the prevention of bacteremia in patients in intensive care units
(Universidad Privada Norbert Wiener, 1905-07-09) Caballero Malaver, Mónica Elena; Samanamú Mauricio, Gabriela Cecilia; Gómez Gonzales, Walter Edgar
Objective: Determine the effectiveness of the use of chlorhexidine dressings for central venous catheters, for the prevention of bacteremia in patients in intensive care units. Materials and methods: Systematic Review, observational and retrospective research design, the search has been restricted to articles with full text, and the selected articles were subjected to a critical reading according to the degree of evidence that synthesizes the results of 01 Meta-analysis and 03 scientific articles that demonstrate the powerful bactericidal activity of the use of dressings with Chlorhexidine for central venous catheters as a preventive measure against bloodstream infections. Results: 1 meta-analysis and 3 articles were chosen in which we found that 50% (02) correspond to the United States with 25% (01), we find France and Israel with 25% (01) respectively. Of the total number of articles analyzed, 100% affirm the effectiveness of the use of dressings with chlorhexidine for CVC in the prevention of bacteremia and infections. The meta-analysis included 9 primary studies that showed a significant reduction in the incidence of infections due to colonization of the central venous catheter as well as bloodstream infection. A randomized trial demonstrated that the use of dressings impregnated with Chlorhexidine gel decreases the rate of CRF in ICU patients with a central venous catheter. A prospective comparative trial provided excellent results of bactericidal and antimicrobial action of the use of transparent dressings impregnated with CHG and finally a randomized controlled study was carried out in a pediatric cardiac intensive unit where gluconate sponge impregnated with chlorhexidine is safe and significantly reduces rates. of CVC colonization in infants and children after cardiac surgery. Conclusion: It was evident in the reviewed research that there is effectiveness in the use of adhesives with chlorhexidine for venous catheters in the prevention of bacteremia since it reduces the percentages of bacteremia associated with central venous catheters, therefore reducing hospital stay, deaths and costs. .
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EFICACIA DEL BUNDLE PARA DISMINUIR LA MORTALIDAD EN LOS PACIENTES CON SEPSIS SEVERA EN UNIDADES CRTICAS
(Universidad Privada Norbert Wiener, 2018-07-08) Carranza Manco, Alexis Armando; Glenni Garay, Zarely
Revisión sistemática, sometidos a le lectura crítica y utilizando el sistema de evaluación GRADE para la identificación del grado de evidencia de los artículos publicados en las siguientes bases de datos: PubMed, Sciencedirect, Redalyc, Scielo, Researchgate. Epistemonikos. De los 10 artículos revisados sistemáticamente, el 20% (n= 2/10) son revisión sistemática, el 10% (n= 2/10) son metaanálisis y 70% (n= 7/10) son estudios de cohorte y proceden de los países de Estados unidos (20%), Brasil (20%), China (20%) seguida de Italia (10%), Australia (10%), Francia (10%) y Holanda (10%). El 100% (n=10/10) señalan que el bundle es eficaz para disminuir la mortalidad en los pacientes con sepsis en unidades críticas. Conclusión: El bundle es eficaz para disminuir la mortalidad en los pacientes con sepsis en unidades críticas.
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Evidence on nursing interventions for the prevention of bacteremias in patients with central venous catheters
(Universidad Privada Norbert Wiener, 2017-12-03) Montalvo Huamaní, Elida Silvia; Quispe Mozombite, Katherine Fiorella; Matta Solis, Hernán Hugo
Objectives: To systematize the evidence on nursing interventions for the prevention of catheter-related bacteremia in patients with central venous catheters in the intensive care unit. Materials and Methods: This is an observational and retrospective systematic review, which focused on systematic reviews with full-text articles. These articles were selected after being critically assessed using the GRADE evaluation system to determine their level of evidence. Results: The review observed that hand hygiene is the primary intervention, with an effectiveness rate of 40% (4), followed by 30% (3) indicating that the use of chlorhexidine in dressing changes improves the effectiveness of prevention, 20% (2) finding that the timing of dressing changes is effective, and 10% (1) indicating that the maintenance of lumen patency is important. A total of 100% of the studies confirmed that nursing interventions are effective in preventing bacteremia. Conclusions: Of the 10 articles reviewed, 40% (4) identified hand hygiene as the primary intervention, demonstrating the effectiveness of nursing care for patients with central venous catheters in the intensive care unit.
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Evidence on nursing interventions for the prevention of bacteremias in patients with central venous catheters
(Universidad Privada Norbert Wiener, 2017-12-03) Montalvo Huamaní, Elida Silvia; Quispe Mozombite, Katherine Fiorella; Matta Solis, Hernán Hugo
Objectives: To systematize the evidence on nursing interventions for the prevention of catheter-related bacteremia in patients with central venous catheters in the intensive care unit. Materials and Methods: This is an observational and retrospective systematic review, which focused on systematic reviews with full-text articles. These articles were selected after being critically assessed using the GRADE evaluation system to determine their level of evidence. Results: The review observed that hand hygiene is the primary intervention, with an effectiveness rate of 40% (4), followed by 30% (3) indicating that the use of chlorhexidine in dressing changes improves the effectiveness of prevention, 20% (2) finding that the timing of dressing changes is effective, and 10% (1) indicating that the maintenance of lumen patency is important. A total of 100% of the studies confirmed that nursing interventions are effective in preventing bacteremia. Conclusions: Of the 10 articles reviewed, 40% (4) identified hand hygiene as the primary intervention, demonstrating the effectiveness of nursing care for patients with central venous catheters in the intensive care unit.
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Immature platelet fraction and thrombocytopenia in patients with sepsis care at the San José del Callao hospital-Peru, period january to april 2024
(Universidad Privada Norbert Wiener, 2023-12-03) Chambi Cunga, Isabel Rosa; Astete Medrano, Delia Jessica
Thrombocytopenia is defined as a reduction in the number of circulating platelets in the blood, leading to a platelet count of less than 150,000/μl. This condition can result in potentially severe hemorrhagic complications. Therefore, there is a clear need for extensive research analyzing the relationship between immature platelet fraction and thrombocytopenia in patients with sepsis treated at the San José Hospital in Callao. The purpose of this study is to identify possible correlations, establish patterns, and provide a more comprehensive approach for managing and treating patients with thrombocytopenia caused by sepsis in this hospital setting.
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Índice neutrófilo/linfocito y procalcitonina en pacientes con sepsis del Hospital Nacional Guillermo Almenara Irigoyen, Lima-2023
(Universidad Privada Norbert Wiener, 2025-02-09) Pillco Quispe, Fray Richard; Huamán Cárdenas, Víctor Raúl
El proyecto de investigación llevado a cabo, tuvo por objetivo “Determinar la relación entre los niveles del índice neutrófilo/linfocito y los niveles de procalcitonina en pacientes hospitalizados con sepsis en el Hospital Nacional Guillermo Almenara Irigoyen, Lima 2023”. El método de investigación utilizado, fue hipotético deductivo; con un enfoque cuantitativo y nivel correlacional. Además, el diseño utilizado fue el no experimental. La población de estudio estuvo constituida por 120 historias clínicas de pacientes con diagnóstico de sepsis, para la muestra se consideró 91 historias clínicas.
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Microbiological profile and resistance of blood infections in patients of the Nuevo Chimbote hospital, 2023 – 2024
(Universidad Privada Norbert Wiener, 2024-07-20) Colchado Delgado, Damarys Mahanaim; Astete Medrano, Delia Jessica
Objective: To determine the microbiological profile and antimicrobial resistance of microorganisms isolated from the bloodstream of ICU patients at the "Eleazar Guzmán Barrón" Regional Hospital in Nuevo Chimbote, January-December 2023, and January-March 2024. Materials and Methods: The study is non-experimental, retrospective and prospective, quantitative in approach, and applied in type, with a census sample comprising the entire study population. Results: 42 positive samples were found from 32 patients, representing 4% positivity. An increase was observed in patients aged 57, with the predominant sex being male (59.4%). Among microbial species, Staphylococcus epidermidis was the most prevalent, causing 31.3% of the cases. Enterobacter spp. showed 50% resistance to cefotaxime, oxacillin, levofloxacin, and amoxicillin-clavulanic acid. Klebsiella pneumoniae showed resistance to ceftriaxone and cefepime (86% in both cases) and complete resistance (100%) to ampicillin-sulbactam. Pseudomonas aeruginosa was resistant to ceftriaxone and rifampicin (88% in both). Staphylococcus epidermidis showed 30% resistance to ciprofloxacin, cefotaxime, ceftriaxone, and cefuroxime. Staphylococcus aureus showed 20% resistance to ceftriaxone and cefuroxime and 60% resistance to gentamicin. Conclusion: A diverse microbiological profile was found in bloodstream infections in ICU patients at Nuevo Chimbote Hospital, with a prevalence of both gram-positive and gram-negative bacteria. Antimicrobial resistance was observed in several pathogens.
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Neutrophil/Lymphocyte index and procalcitonin index in patients with sepsis hospitalized in a private clinic, Lima 2021
(Universidad Privada Norbert Wiener, 2023-05-07) Limaymanta Cárdenas, Milagros del Rosario; Avelino Callupe, Paul Fortunato
Sepsis is one of the leading causes of high hospitalization rates and mortality in intensive care units for both adults and newborns. Sepsis diagnosis is often delayed due to symptom similarities with other conditions. Various diagnostic methods, such as procalcitonin levels and blood culture (hemoculture), are used, but not all healthcare centers have access to these tests due to shortages of materials and high costs. Thus, there is a need to explore the neutrophil/lymphocyte ratio as a low-cost alternative and easy-to-access marker for presuming sepsis diagnosis.
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Relación entre los índices plaquetarios y los niveles de dímero D en pacientes con sepsis en el Hospital PNP Luis N. Sáenz, 2024
(Universidad Privada Norbert Wiener, 2025-12-04) Vino Sánchez, Martha María; Huamán Cárdenas, Víctor Raúl
La sepsis es un síndrome clínico complejo asociado con alta mortalidad y desregulación de la coagulación, en el que los índices plaquetarios y el dímero D han sido propuestos como posibles biomarcadores de pronóstico. El objetivo del presente estudio fue determinar la relación que existe entre los índices plaquetarios y los niveles de dímero D en pacientes con sepsis. Se realizó un estudio cuantitativo, retrospectivo y transversal en una muestra de 83 pacientes hospitalizados con diagnóstico de sepsis entre enero y julio de 2024. Se analizaron el recuento plaquetario, el volumen plaquetario medio (VPM), la amplitud de distribución plaquetaria (PDW), el plaquetocrito (PCT) y los niveles de dímero D. Para el análisis de la asociación se utilizó la correlación de Spearman. Los resultados mostraron correlaciones muy fuertes y significativas (p < 0,001) entre los índices plaquetarios y el dímero D: recuento plaquetario (Rho = –0,865), VPM (Rho = 0,819), PDW (Rho = 0,818) y PCT (Rho = –0,816). Estos hallazgos evidencian que la disminución del número y masa plaquetaria, junto con la mayor heterogeneidad y tamaño de las plaquetas, se asocian a un incremento de la actividad trombótica reflejada en el dímero D. En conclusión, los índices plaquetarios, obtenidos de un hemograma rutinario, muestran una estrecha relación con el dímero D en pacientes con sepsis, lo que resalta su aplicabilidad clínica como predictores indirectos de la desregulación hemostática en esta condición.