Examinando por Autor "Chávez Fernández, Ana María"

Mostrando 1 - 8 de 8

Acceso abierto
Actividad anticonvulsivante del extracto hidroalcoholico de raíz de Valeriana pinnatifida R. & P. "Valeriana"
(Universidad Privada Norbert Wiener, 2018-11-24) Anco Maximiliano, Yanet Soleda; Chávez Fernández, Ana María
Valeriana pinnatifida is a native plant of the Valerianaceae family, endemic to Peru, which grows on rocky slopes in the Andes. Traditionally, it has been used as a sedative, hypnotic, and tranquilizer. This study was initiated to analyze the metabolites present in the plant, determine its acute toxicity, and evaluate its anticonvulsant effect. The research was quasi-experimental. For the phytochemical study, a hydroalcoholic extract was obtained from the root of Valeriana pinnatifida R. & P., "valeriana," via maceration. Acute toxicity was determined at a limit dose of 2000 mg/kg using the OECD 423 protocol. The anticonvulsant effect was evaluated using an experimental model of pentylenetetrazol (PTZ)-induced seizures in mice. Five groups of six albino mice of the C53/CNPB strain were used: group 1 (saline control), group 2 (PTZ 80mg/kg), group 3 (diazepam 5mg/kg + PTZ), group 4 (EHVP 300mg/kg + PTZ), and group 5 (EHVP 400mg/kg + PTZ). The treatments were administered orally 30 minutes before the induction of seizures with PTZ. The results identified the secondary metabolites alkaloids and terpenes. The toxicity study showed a significant variation in the weight of the mice. The 300 mg/kg dose demonstrated a statistically significant anticonvulsant activity compared to the control group in terms of seizure severity and mortality. It is concluded that the hydroalcoholic root extract of Valeriana pinnatifida R. & P., "valeriana," at a concentration of 300 mg/kg, exhibits an anticonvulsant effect.
Acceso abierto
Análisis bacteriológico del agua de la fuente de abastecimiento y de jeringa triple de las unidades dentales de clínicas odontológicas en Tarma (Junín), período octubre 2012–febrero 2013
(Universidad Privada Norbert Wiener, 2013) Liñán Trujillo, José Luis; Reynozo Gálvez, Cecilia Elisa; Chávez Fernández, Ana María
In the determination of the bacteriological quality of the water from the supply source and the three-way (air–water) syringe used in the dental units of dental clinics in the city of Tarma (Junín), sampling was conducted in 25 dental clinics with continuous service, for a total of 30 water samples: 5 from the supply source and 25 from the three-way syringe. Counts were made of heterotrophic bacteria, total coliforms, thermotolerant coliforms, Escherichia coli and the presence of Pseudomonas aeruginosa, using the membrane filtration method based on Standard Methods for the Examination of Water and Wastewater (AWWA, APHA and WEF), and following the guidelines of the Peruvian Ministry of Health (MINSA) Regulation on Water Quality for Human Consumption. Culture media and glassware were prepared and sterilized at Félix Mayorca Soto Hospital. The analysis of potable water samples was carried out in the laboratory of the Pharmacy technical programme at Instituto Santa Lucía in the city of Tarma (Junín). At all times, the work was supported by specialized professionals in the Clinical Laboratory area. It was observed that the five supply-source water samples showed absence of total coliforms, thermotolerant coliforms, Pseudomonas aeruginosa, Escherichia coli, and fewer than 500 CFU of heterotrophic bacteria. In contrast, analysis of the 25 three-way syringe water samples showed the presence of total coliforms in 88% of the dental offices, fecal coliforms in 32%, heterotrophic bacteria in 20%, Pseudomonas aeruginosa in 16%, and Escherichia coli in 8%. Therefore, only three water samples from the dental clinics complied with the parameters established by MINSA.
Acceso abierto
Análisis fisicoquímico en condiciones normales y de estabilidad acelerada de amoxicilina tabletas recubiertas de fiable y dudosa procedencia en el Cercado de Lima, diciembre de 2012
(Universidad Privada Norbert Wiener, 2013) Santiago Valverde, Frank Eleazar; Torres Aguirre, Milagros Jacqueline; Chávez Fernández, Ana María
The increasing commercialization of adulterated medicines and the lack of adequate regulatory control in the Peruvian pharmaceutical market represent a risk to patient health. This study aimed to contribute to the control and sanitary surveillance of amoxicillin film-coated tablets. Amoxicillin was selected as the study sample because it is classified as an essential medicine. Three main aspects were evaluated. First, the origin of the medicines was analyzed using checklists based on Supreme Decrees No. 014-2011/SA and No. 016-2011/SA. Second, the physicochemical properties of medicines from both reliable and questionable sources were assessed according to the Amoxicillin Tablets monograph and general chapters <905> and <1151> of the United States Pharmacopeia (USP 35). Third, the stability behavior of amoxicillin was evaluated under partial accelerated stability conditions following Health Directive No. 031-MINSA/DIGEMID. The results showed that the sample from a reliable source complied with all requirements of the Supreme Decrees. Questionable source samples 2 and 3 met the requirements of Supreme Decree No. 016-2011/SA, while sample 1 did not. Furthermore, the establishments from which questionable samples were collected failed to comply with Supreme Decree No. 014-2011/SA. All samples, however, complied with USP 35 acceptance criteria and the national directive regarding physicochemical quality and stability. In conclusion, although amoxicillin marketed in both pharmaceutical and non-pharmaceutical establishments met physicochemical quality standards and demonstrated stability under accelerated conditions, non-pharmaceutical establishments failed to comply with current Peruvian regulatory requirements.
Acceso abierto
Caracterización del consumo de medicamentos; automedicación responsable, automedicación y autoprescripción en usuarios de boticas ubicadas en San Juan de Lurigancho 2016–2017
(Universidad Privada Norbert Wiener, 2018-04-03) Calla Calla, Hermelinda María; Rosales Zurita, Verónica Vilvia; Chávez Fernández, Ana María
Irresponsible self-medication and self-prescription practices have increased among users of drugstores, becoming a public health problem. In Peru, regarding the use of health services, pharmacies and drugstores constitute the preferred places of care (MINSA 2013). The WHO advised that countries’ health policies should take responsible self-medication into account and seek ways to optimize its use with over-the-counter medicines under the supervision of a pharmacist. In our context, the practice of responsible self-medication is infrequent; however, its dissemination could reduce the overload in hospitals and health centers. For all the reasons stated, this research was considered important. It is concluded that 6.2% of drugstore users practice responsible self-medication, while 23.5% only self-medicate, and 70.3% self-prescribe. It is recommended to inform drugstore users, using simple language, about the existence of two groups of medicines established by law, and to provide education on when a condition should be considered minor and why. These tasks fall primarily on the expert in medicines, the pharmacist, since drugstores are the first places people go when they become ill.
Acceso abierto
Evaluación microscópica, rotulado y peso promedio de cápsulas de Spirulina platensis de dudosa procedencia comercializadas en las Galerías Capón Center, Hierba Santa 1 y 2 del distrito de Lima y La Victoria, Lima 2015–2016
(Universidad Privada Norbert Wiener, 2017-11-13) Pariona Puma, Gina Janina; Mansilla Salvatierra, Elizabeth; Chávez Fernández, Ana María
The objective of this study was to determine, through microscopic evaluation, labeling analysis, and average weight testing, the presence of Spirulina platensis in capsules of dubious origin marketed in Capón Center and Hierba Santa 1 and 2 galleries, in the districts of Lima and La Victoria (2015–2016). The study also assessed compliance with labeling requirements according to current legal regulations and pharmacopeia recommendations for average weight. This explanatory, observational, cross-sectional, descriptive, and comparative study first conducted a microscopic evaluation of Samples of Dubious Origin (SDO) compared with a standard, where 8.3% showed non-compliance. Second, labeling was evaluated in both reliable and dubious origin capsules based on Supreme Decree N°016-2011-SA and amendments, where 91.7% showed non-compliance and only 8.3% (SDO7) complied. Verification of the RUC number in SUNAT revealed that 50% of manufacturers were not registered, including SDO7. Finally, average weight evaluation according to official pharmacopeia references showed that 16.7% (SDO2 and SDO8) did not comply. In conclusion, none of the evaluated Spirulina platensis capsule samples fully complied with all established requirements.
Acceso abierto
Interacciones medicamentosas potenciales en pacientes con cáncer de mama del servicio de medicina paliativa del Instituto Nacional de Enfermedades Neoplásicas
(Universidad Privada Norbert Wiener, 2017) Barrios Jara, Elizabeth Yessica; Chávez Fernández, Ana María
The present study was carried out with the purpose of determining the potential drug interactions in prescriptions dispensed to breast cancer patients from the Palliative Medicine Service of the National Institute of Neoplastic Diseases (INEN) during the period November 2015 – October 2016. A non-experimental, descriptive, retrospective, cross-sectional study was conducted, analyzing 316 prescriptions that met the inclusion and exclusion criteria. In 287 (90.82%), at least one potential drug interaction (PDI) was identified. When performing Pearson’s correlation between the number of prescribed drugs and the number of PDIs, the relationship was found to be highly significant (sig = 0.00 < 0.05), and the correlation coefficient (Rho = 0.481) indicated a moderate positive correlation. A total of 889 PDIs were identified, the most frequent being tramadol + amitriptyline (13%), metoclopramide + amitriptyline (10%), and morphine + amitriptyline (9%). According to their mechanism of production, 218 (24.5%) were pharmacokinetic in origin, 489 (55.0%) pharmacodynamic, and 182 (20.5%) unknown. According to their severity level, 91 (10.2%) were contraindicated, 439 (49.4%) major, 348 (39.1%) moderate, and 11 (1.2%) minor. It is concluded that the presence of PDIs is evident and that the intervention of the Pharmaceutical Chemist is necessary to prevent possible adverse events.
Acceso abierto
Nivel de cumplimiento de la Norma Técnica de Salud Nº 122- MINSA/DIGEMID-V.01 en prescripción de fórmulas magistrales dermatológicas atendidas en tres Oficinas Farmacéuticas Especializadas
(Universidad Privada Norbert Wiener, 2017) Araujo Aviles, Ivon Izen; Chavez Chuquillanqui, Maybe; Chávez Fernández, Ana María
Observational-cross-sectional design study, carried out in the period February - April 2017 in three specialized pharmaceutical offices, 300 prescriptions were taken from each of the three pharmaceutical establishments, obtaining a total of 900 prescriptions as a sample, the level of compliance in the prescription of dermatological master formulas was evaluated and contrasted with the criteria established in the aforementioned standard, a research instrument was designed with the prescription criteria established in the technical standard, after analysis, evaluation and processing of the sample, the following results were obtained: the criteria Validity of the prescription and Age have not been met at all. Regarding the criterion Name and surname of the patient only 34.8% complied with the correct filling, the criterion Duration of treatment presented a 13.6% level of compliance, the criterion Pharmaceutical Form presented a level of compliance of 37.3%, The criterion Name of the pharmaceutical preparation presented a 3.7% level of compliance. Therefore, it is concluded that errors in the prescription of magistral formulas contribute to the deficiency in compliance with Technical Health Standard No. 122 - MINSA/DIGEMID - V.01, the physician omits certain criteria established by the current Regulations and good prescription practices, which is why we propose a standard prescription model for magistral formulas.
Acceso abierto
Validación e implementación del método analítico del monitoreo de superficie por hisopado en la industria farmacéutica
(Universidad Privada Norbert Wiener, 2018-10-10) Díaz Fernández, Martha María; Chávez Fernández, Ana María
The present study was carried out with the purpose of evaluating the different methods of surface monitoring carried out in the pharmaceutical industry 2016 - 2017. A Field, Descriptive - Longitudinal, Qualitative and Applied study was carried out. To this end, the parameters were evaluated according to the United States Pharmacopoeia (USP 40 NF 35) Validation of alternative microbiological methods, microorganisms similar to those found were selected (biological standard) in the manufacturing processes of pharmaceutical products, it was evaluated that the working material, the levels of detection were defined and applied to the different methods of surface monitoring in evaluation. It is observed that although the methods do not present homogeneous results; It is considered the method that presents the highest percentage (%) of recovery, in more than one ATCC. It is the Regular Hyssop method of Plastic Soft Nylon Point Sterile Flocked + Shock absorber Solution Sodium Chloride - Peptone. ATCC 9027 (15.30%); ATCC 6538 (41%) and ATCC 8739 (17.4%). That is why this study us to know the importance of importance of identifying and evaluating the proposed methods for the pharmaceutical industry, which is always in constant improvement and innovating in methods to streamline results. The purpose is to avoid false positives or negatives and to guarantee the quality and safety of pharmaceutical products.