Examinando por Materia "Control de Calidad"

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Acceso abierto
La adulteración y calidad desinfectante del alcohol expendido en oficinas farmacéuticas y otros establecimientos comerciales, Lima – Cercado, setiembre 2020
(Universidad Privada Norbert Wiener, 2022-05-19) Vargas Espinal, Maribel Juvenalda; Laureano Peña, Haydee Sonia; Llahuilla Quea, José Antonio
The methodology used consisted of a random probabilistic sampling of 32 samples of 96° ethyl alcohols in 1 L bottles sold in pharmaceutical offices (sample B: 15 samples from drugstores and pharmacies) and other commercial establishments (sample A: 17 samples from small shops, shopping centers, and street vendors). Methanol was identified using the chromotropic acid reaction method. A sensory evaluation was conducted according to Peruvian Technical Standard 211.007:2014. The determination of physicochemical parameters (pH, alcoholic strength, and density) was performed according to the United States Pharmacopeia and Peruvian Technical Standard 319.229:2014. Disinfectant effectiveness was determined in accordance with the UNE-EN 1040 method for chemical antiseptics and disinfectants. The results identified positive methanol results in 13.3% of the B samples and 11.76% of the A samples. The alcoholic strength showed results lower than 96°, with an average of 93 in the B samples and 79 in the A samples. Additionally, the disinfectant effectiveness in the sample with the lowest alcoholic strength for group B showed a bactericidal activity greater than 99.99% at 30 seconds of contact against the microorganisms S. aureus and P. aeruginosa, while for group A, no bactericidal activity was observed.
Acceso abierto
Aplicación de la espectroscopía en el infrarrojo cercano – NIR para el análisis cualitativo del principio activo naproxeno sódico
(Universidad Privada Norbert Wiener, 2015) Auccapuclla Chuquihuaccha, Sindy; Navarro Juárez, Pascuala Elizabeth; Palomino Fernández, Edgar
Near-infrared spectroscopy (NIR) was applied in the pharmaceutical industry with the aim of proposing an alternative instrumental method for the qualitative analysis of the active ingredient Naproxen Sodium. For the proposed method, a library was created containing active pharmaceutical ingredients with structural formulas of propionic acid anti-inflammatory derivatives, as well as active ingredients with similar physical characteristics, making a total of 19 inputs included in the library. To establish the method, the primary packaging of the input was first identified, and five different batches previously approved by the traditional method and compared against a primary standard were selected. Once the spectra were acquired, they were processed using the Savitzky–Golay filter to minimize spectral noise, followed by a spectral matching algorithm and subsequently classified based on the k-nearest neighbors (k-NN) method. Internal and external validation of the proposed method was carried out in accordance with USP <1225> guidelines, category 4. The fundamental performance attribute validated for the identification test was selectivity (specificity), defined as the ability of a method to selectively discriminate the identity of the chosen analyte from all potential interfering substances. This method is relevant as it reduces sampling and analysis time, while also minimizing analyst exposure and preventing the input from being exposed to the environment.
Acceso abierto
Buenas prácticas de distribución y transporte, manteniendo la cadena de frío 2°C a 8°C en productos terminados de Paclitaxel Paclitex®, Toxina Botulínica Cunox® y Octreotide Azestan®
(Universidad Privada Norbert Wiener, 2015) Moreto Riofrio, Oscar Reinaldo; Carhuapoma Yance, Mario
In the preservation of the cold chain, the weakest and most critical stage is undoubtedly transportation during the distribution of finished products. It is essential to identify suitable materials to maintain the cold chain through a series of tests, which must be documented to demonstrate that a certain quantity of Gel Ice Packs combined with appropriately sized Cold Boxes ensures temperature control within a predefined period. This guarantees compliance with good distribution and transportation practices. In this study, a method was developed to ensure the proper distribution and conservation of finished pharmaceutical products requiring a specific temperature of 2°C to 8°C to maintain their stability. Cold Boxes from different suppliers were purchased, evaluated, and compared to assess their performance in preserving the cold chain. Gel Ice Packs, accompanied by certificates describing their chemical composition and freezing point, were analyzed and approved by an authorized health network laboratory. Storage equipment and facilities used for products such as Paclitaxel PACLITEX®, Botulinum Toxin CUNOX®, and Octreotide AZESTAN® were calibrated, certified, and maintained under a periodic maintenance program. Field tests were conducted in three provinces with extreme seasonal temperatures. Based on the results of the first and second phases, an instructional guide was prepared for proper product packaging. Finally, the fourth and fifth tests were carried out in Callao and Lima, respectively, using optimal quantities and sizes of materials, with satisfactory results confirmed by temperature controllers (Temptale4) graphs.
Acceso abierto
Calidad de servicio y satisfacción del usuario de una botica del distrito de Los Olivos, Lima – 2026
(Universidad Privada Norbert Wiener, 2026-04-22) Navarro Ordinola, Victor Hugo; Elguera Pajares, Ana Lorena
El estudio tuvo como objetivo general determinar la relación entre la calidad de servicio y la satisfacción del usuario en una botica del distrito de Los Olivos, Lima – 2026. La investigación adoptó un enfoque cuantitativo, con un tipo aplicado y diseño no experimental, transversal y correlacional, ya que no se manipularon variables y se buscó analizar el vínculo entre ambas variables en su entorno natural. La población estuvo conformada por 1,500 usuarios de la botica y la muestra fue de 306 personas, seleccionadas mediante un muestreo probabilístico aleatorio simple. Se empleó la encuesta como técnica y el cuestionario como instrumento, utilizando los modelos SERVQUAL para medir la calidad del servicio y el Expectativa–Desempeño (EDM) para evaluar la satisfacción del usuario. Los datos se procesaron con el programa SPSS v27, aplicando análisis descriptivos e inferenciales. Los resultados revelaron una correlación moderada, positiva y significativa (Rho de Spearman = 0.546; p < 0.001) entre la calidad del servicio y la satisfacción del usuario, confirmando la hipótesis planteada. Se concluye que una mayor percepción de calidad en el servicio genera una mayor satisfacción, evidenciando la necesidad de fortalecer dimensiones como la empatía, fiabilidad y tangibilidad en el sector farmacéutico.
Acceso abierto
Causas y frecuencia de rechazo de muestras bioquímicas en pacientes del Laboratorio Clínico Ocupacional Natclar - Lima 2025
(Universidad Privada Norbert Wiener, 2026-03-17) Gamarra Carpio, Gian Gregory; Borja Velezmoro, Gustavo Adolfo
El presente trabajo de investigación tuvo como objetivo exponer las causas y frecuencia de rechazo en muestras de bioquímica, para pacientes del laboratorio clínico ocupacional de la clínica Natclar. Método: Estudio de método descriptivo, de enfoque cuantitativo, de tipo básica, de diseño no experimental, descriptivo y retrospectivo, transversal; al analizar datos en un período definido. La población total está conformada de 2480 pacientes de los cuales 1736 son hombres y 744 mujeres, teniendo una muestra 340 pacientes rechazados. El instrumento fue una ficha de recolección de datos. Resultados: se identificó que 75 individuos fueron descartados por consumo de medicamento: 33.33% utilizaron metformina, 20% antibióticos, 9.33% aines, 26.67% estatinas y 10.67% corticoides, siendo la metformina el fármaco predominante. Respecto a la enfermedad, 55 pacientes fueron rechazados: 18.18% presentaron diabetes, 14.55% gastritis, 10.91% hipertensión, 27.27% hígado graso, 7.27% hiperlipemia severa y 21.82% lipemia, predominando hígado graso. Así mismo, las principales causas de rechazo fueron, 35.29 % por causa de ayuno, 22.06 % por medicamentos, 16.18 % por enfermedad, 11.76 % por alcohol, 8.24 % por tabaco y 6.47 % por ejercicio. Conclusión: Se encontró que las causas con frecuencia alta fueron ayuno, medicamentos, enfermedad y alcohol, mientras que las de frecuencia moderada fueron tabaco y ejercicio; no se registró frecuencia baja (<5%). Finalmente, la frecuencia global de rechazo fue de 13.71% del total de pacientes atendidos.
Acceso abierto
Competencias del director técnico en la detección organoléptica de medicamentos falsificados de especialidad farmacéutica en las oficinas farmacéuticas
(Universidad Privada Norbert Wiener, 2018-11-14) Atencio Paucar, Jackelinne Karin; Vásquez López, Orfelinda Marciomila; Ramos Jaco, Antonio Guillermo
The study was conducted to determine the competence of the Technical Director in the organoleptic detection of counterfeit pharmaceutical specialty medicines in community pharmacies. Methodology: A descriptive, cross-sectional, retrospective, and observational design was applied to assess competencies, skills, and attitudes. Two instruments were developed: a questionnaire to evaluate the knowledge and attitude of the Technical Directors, and a technical data sheet to assess skills and the organoleptic evaluation of pharmaceutical specialty medicines. The study included a total of 257 community pharmacies (pharmacies and drugstores). Data analysis was performed using the statistical software SPSS, version 25. Results: Of the 257 (100%) respondents, the largest group corresponded to the medium knowledge level with 64.59% (166), followed by the high knowledge level with 20.22% (53), and the low knowledge level with 14.79% (38). Regarding skills, the group with low skills predominated with 45.14% (116), followed by medium-level skills with 38.52% (99), and high-level skills with 16.34% (42). In terms of attitude, the group with low-level attitudes was the most frequent with 38.91% (100), followed by medium attitudes with 35.80% (92), and high attitudes with 25.29% (65). Conclusion: Among the 257 Technical Directors, the predominant level of knowledge was medium in relation to the organoleptic detection of counterfeit medicines. In contrast, both skills and attitudes were predominantly at a low level.
Acceso abierto
Conocimiento sobre buenas prácticas de almacenamiento en estudiantes de farmacia y bioquímica de la Universidad Norbert Wiener del octavo y noveno ciclos, Lima, julio del 2017
(Universidad Privada Norbert Wiener, 2018-08-24) Calderón Ramos, Milagros; Oyanguren Sarmiento, Katyhusca Mercedes; Segura Vílchez, Tito Magno
This study aimed to determine the level of knowledge regarding Good Storage Practices among Pharmacy and Biochemistry students of the eighth and ninth semesters at Universidad Norbert Wiener. This research was developed because the Good Storage Practices Manual is constantly applied in the professional field. The study was grounded in the experience gained as graduates of the Faculty of Pharmacy and Biochemistry, and based on the syllabi of related courses, with the goal of improving them. The results showed that, out of a total of 130 students, 41.54% demonstrated a low level of knowledge, 49.23% a medium level, and 9.23% a high level. Since the most frequent outcome was a medium level of knowledge, it was concluded that one of the main factors is the insufficient number of academic hours dedicated to this topic, which hinders optimal learning for graduates. It is recommended to standardize the teaching hours for this subject, balancing the coverage of Good Storage Practices with Good Manufacturing Practices, as these competencies are essential in the professional field.
Acceso abierto
Control de proceso en la fabricación de comprimidos recubiertos de diclofenaco sódico 50 mg tableta con recubrimiento entérico
(Universidad Privada Norbert Wiener, 2017-12-07) Rodriguez Bardalez, Ireny; Jáuregui Maldonado, José Fidel
The present work validates the activities carried out during the manufacturing process control of 50 mg coated diclofenac sodium tablets, with the objective of demonstrating, through documented evidence, that the specific manufacturing process is under control and consistently and reproducibly provides a product that meets the previously established quality specifications. In the mixing phase, the following tests were performed: appearance, particle size distribution, bulk density, and moisture content. In the pre-lubrication granulate phase, the tests conducted were: appearance and moisture content. In the third phase, the lubricated granulate, the following parameters were evaluated: appearance, particle size distribution, bulk density, mixing of the active pharmaceutical ingredient with excipients and lubricants, moisture content, and angle of repose. During the compression phase, the following tests were carried out: appearance, weight uniformity, hardness, thickness, friability, active pharmaceutical ingredient content uniformity, dosage uniformity, dissolution, and moisture content. In the coating phase (coating 2), the tests performed were: appearance, weight uniformity, dissolution, and moisture content. For data analysis, statistical methods were employed, using control charts for means (X) and standard deviation (S) for each selected variable. The data for the appearance test of the tablets with coating 2 were analyzed using a proportion chart (p). Process capability was calculated for critical variables such as weight uniformity, hardness, and content uniformity, obtaining acceptable values.
Acceso abierto
Cumplimiento de buenas practicas de almacenamiento y procedimientos operativos en droguerias que contratan el servicio de almacenamiento en Somefarm S.A.C. Lima – 2021
(Universidad Privada Norbert Wiener, 2022-09-24) Salinas Segura, Roger; Aquino Comun, Mery
The objective of this research was to determine the level of compliance with Good Storage Practices (GSP) for the proposal and implementation of Standard Operating Procedures (SOPs) in drugstores that contract third-party storage services at Somefarm S.A.C., Lima-2021. Method: The method was deductive, with an applied type, quantitative approach, descriptive level, longitudinal scope, and non-experimental design. The instrument used was the inspection guide for drugstores, specialized warehouses, and customs warehouses that store Pharmaceutical Products, approved by Ministerial Resolution (R.M.) N° 132-2015/MINSA. Results: The general level of GSP compliance was initially low to medium, with only 35% of drugstores at a high level, 55% at a medium level, and 10% at a low level. Compliance with GSP based on SOPs was also measured, with only 30% of drugstores at a high level, 50% at a medium level, and 20% at a low level. Following these initial results, 21 SOPs and two manuals were implemented in the deficient drugstores, and GSP compliance was measured again. The general compliance level improved, with 50% of drugstores now at a high level, 35% at a medium level, and 15% at a low level. Compliance with GSP based on SOPs also improved, with 60% of drugstores at a high level, 25% at a medium level, and 15% at a low level. Conclusion: The implementation of SOPs improves the level of compliance with GSP.
Acceso abierto
Cumplimiento de las buenas prácticas de prescripción y análisis de las buenas prácticas de dispensación y expendio en recetas médicas atendidas en Botica Latina y Botica Líder durante el periodo enero–marzo 2019
(Universidad Privada Norbert Wiener, 2022-11-25) Castañeda Salazar, Lorena Jaqueline; Hernández Medina, Shirley Olga; Félix Véliz, Luis Miguel Visitación
The purpose of this thesis was to verify compliance with Good Prescribing Practices (GPP) and analyze Good Dispensing and Sales Practices in Botica Latina and Botica Líder in the San Martín de Porres and San Juan de Lurigancho districts, respectively, during the period of January–March 2019. A descriptive and prospective study was conducted, in which 270 medical prescriptions were evaluated and received from hospitals, clinics, solidarity hospitals, polyclinics, and private practices. 106 were from Botica Latina and 164 were from Botica Líder. To evaluate compliance with Good Prescribing Practices, the Manual of Good Prescribing Practices from the Ministry of Health and the General Directorate of Medicines, Supplies, and Drugs of Peru was used, as well as the respective manual for the analysis of good dispensing practices. It was found that 78.5% (212 prescriptions) omitted the patient's age, 76.3% (206 prescriptions) omitted the diagnosis, and 93% (251 prescriptions) omitted the issuance and expiration date. 65.2% (176 prescriptions) omitted the INN (International Nonproprietary Name), 43% (116 prescriptions) omitted the concentration, and 39.3% (106 prescriptions) omitted the dose frequency. Consequently, it is concluded that there is non-compliance with Good Prescribing Practices, which will limit dispensing in both districts.
Acceso abierto
Determinación de la calidad de la materia prima celecoxib en seis lotes diferentes mediante los resultados de ensayos fisicoquímicos según USP 39, Lima 2016–2017
(Universidad Privada Norbert Wiener, 2017-11-25) Felipe Chávez, Ross Bereniz; Lázaro Cartolín, Johana Milagros; Guevara Ortega, Freddy Alberto
The present research work was conducted with the objective of determining the quality of celecoxib raw material in six different batches through the results of physicochemical tests according to USP 39. The study population consisted of six batches of raw material analyzed in the quality control area of a national pharmaceutical laboratory, during the period from May 2016 to February 2017. The research methodology was carried out in accordance with the specifications of the USP 39 technical standard. The results were: 100% compliant in description, 100% compliant in identification, 100% compliant in solubility, 100% compliant with less than 0.1% in water determination, 100% compliant with less than 0.2% in residue on ignition, 100% compliant with no more than 20 ppm of heavy metals, 100% compliant with no more than 0.5% in organic impurities, and 100% compliant in assay within a range of 98.0% – 102.0%. These results indicated that the celecoxib raw material from different batches, received by a national pharmaceutical laboratory during the period from May 2016 to February 2017, meets the quality standards established by USP 39, regardless of its place of origin.
Acceso abierto
Determinación de la graduación de etanol en vinos tintos nacionales que se expenden el mercado Unicachi del distrito de Comas – Lima, periodo diciembre 2016–marzo 2017
(Universidad Privada Norbert Wiener, 2017) Cardenas Rivera, Nataly Maria; Melendez Ruiz de la Vega, Leslie Roxana; Hernández Aguilar, Manuel Gregorio
Alcoholic beverages are produced by fermentation and/or distillation processes, reaching different alcoholic strengths ranging from an average of 5% to 50%. Among these is wine, with various types such as red, burgundy, and white, mainly obtained from grapes, which are highly consumed, especially during festivities, meetings, and celebrations. Wines have an alcoholic strength that fluctuates between 10% and 20% v/v, but this can be adulterated or counterfeited by merchants to obtain greater profits. The objective of this research was to determine the alcoholic strength present in the collected national red wines and verify if these strengths correspond to the labels, as well as if they are within the range specified by the Peruvian Technical Standard (NTP) N° 212.014:2011. For the study, 30 samples of red wine were analyzed. These were acquired from various stalls at the Unicachi market in the Comas district and subsequently analyzed using a Gas Chromatograph with Flame Ionization Detector (GC-FID). Results reported alcoholic strengths with a minimum value of 1.03% v/v and a maximum value of 8.86% v/v from a total of 30 national red wines of different brands. These findings confirm our hypothesis, which states that the national red wines sold in the Unicachi market do not contain the alcoholic strength consigned on their label, as they present a lower alcohol degree. These results do not comply with the Peruvian Technical Standard (NTP) N° 212.014:2011, which indicates that wine must have a minimum alcoholic strength of 10% v/v.
Acceso abierto
Efectividad de la antisepsia de la piel con clorhexidina comparado con otros antisépticos para la prevención de infecciones en pacientes que requieran del cáteter venoso periférico
(Universidad Privada Norbert Wiener, 2019-09-22) Martinez Vera, Yasmina Tatiana; Rosales Clemente, Raquel Nelly; Bonilla Asalde, César Antonio
Objetivo: Sistematizar las patentes acerca de la efectividad de la antisepsia de la piel para la prevención de infección en pacientes que requieran del uso de catéter venoso periférico. Materiales y Métodos: Revisiones Sistemáticas son indagaciones científicas, donde el elemento de exploración son los trabajos primarios únicos. Es un instrumento fundamental para la síntesis de la referencia científica, incrementando el valor de los resultados de estudios y a su vez identifican áreas que necesitan ser investigadas. Se ejecuta llevando una estricta metodología y un alto control de calidad para evitar conclusiones erróneas, la averiguación está limitado a escritos con contenido íntegro, aquellos elegidos fueron sometidos a una investigación minuciosa, usando el sistema grade que nos permitió consignar la fuerza de recomendación. De la elección final se seleccionaron 10 artículos, de los que encontramos que el 20% (02) pertenecen al país de Japón y Francia, mientras que con el 10% (01) corresponden, respectivamente, a Canadá, Portugal, Singapur, Reino Unido, Estados Unidos e Irlanda. Entre los ensayos clínicos aleatorizados encontramos estudios procedentes de Canadá, Reino Unido, Francia con un 70% y, revisiones sistemáticas procedentes de Portugal, Estados Unidos y Singapur con el 30%. Resultados: De todos los artículos analizados el 80% afirma que la clorhexidina es más efectiva que el uso de otros antisépticos en la prevención de las infecciones. Conclusiones: En las investigaciones revisadas se evidencia que existe efectividad de la antisepsia de la piel con clorhexidina en comparación con otros antisépticos en la prevención de infecciones en pacientes que requieran del catéter venoso periférico.
Acceso abierto
Eficacia del ácido peracético para la desinfección in situ en el área de envasado de formas farmacéuticas estériles en un laboratorio de industria farmacéutica, Lima, septiembre – 2019 a septiembre – 2020
(Universidad Privada Norbert Wiener, 2021-10-22) Torres Maccanascca, Karina; Cardoza Sánchez, Verónica; Pinedo Panduro, Lauro Sócrates
The objective of this study was to demonstrate the efficacy of peracetic acid for the in-situ disinfection of equipment in the 'sterile packaging area 2' for pharmaceutical forms within a pharmaceutical industry laboratory. An experimental, quantitative, and cross-sectional study was conducted using the dilution-neutralization method to determine the efficacy of peracetic acid at concentrations of 0.6%, 1.2%, and 1.8% with contact times of 5, 10, and 15 minutes. For in-situ antimicrobial activity, the contact plate method was used for surfaces and the swab method was used for equipment. Statistical analysis was performed using the Kolmogorov-Smirnov and Kruskal-Wallis methods. It was found that peracetic acid at a 1.2% concentration with a 5-minute contact time showed bacterial and fungal growth, unlike the 10- and 15-minute contact times, where it satisfactorily eliminated them. At the 1.8% concentration, no growth of bacteria or fungi was observed for any exposure time. The determination of antimicrobial activity on surfaces and equipment showed a 99.999% reduction.
Acceso abierto
Equivalencia farmacéutica de medicamentos multifuentes de sildenafilo de 50 mg que se dispensan en el distrito de San Juan de Miraflores – San Juan zona D en los meses de noviembre y diciembre 2017
(Universidad Privada Norbert Wiener, 2018-09-06) Huatuco Amez, Olivia Patrich; Guillén Sulca, Walter Roberto; Cárdenas Orihuela, Robert Armando
When performing the pharmaceutical equivalence of 50 mg sildenafil multi-source medicines dispensed in the district of San Juan de Miraflores during the months of November and December 2017, the objective was to evaluate in vitro the multi-source sildenafil medicines. This drug was chosen because, in recent years in Lima—particularly in the district of San Juan de Miraflores, according to pharmaceutical staff reports—it has been sold with great freedom, and since it is dispensed under different brands, it was necessary to determine whether equivalence existed in relation to the innovator. The methodology used included the corresponding parameters established by the United States Pharmacopeia for solid pharmaceutical forms, evaluating the external aspects and the physical parameters of the tablets, such as weight variation, hardness, disintegration, and friability. The results obtained in this study demonstrated that these pharmaceutical forms are similar with respect to these parameters, meeting the official specifications. The values obtained fall within the accepted averages for oral formulations of 50 mg sildenafil.
Acceso abierto
Estrés laboral y calidad de vida profesional en enfermeros del centro quirúrgico del Hospital Central de la Policía Nacional del Perú, 2022
(Universidad Privada Norbert Wiener, 2022-10-16) Samamé Zavala, Elizabeth Maribel; Pretell Aguilar, Rosa María
Determinar la relación entre el estrés laboral y la calidad de vida profesional en enfermeros de centro quirúrgico. Metodología. El estudio en cuanto a su enfoque será cuantitativo, de tipo aplicado, y de diseño no experimental, descriptivo, y correlacional. En lo que corresponde a la muestra representativa del estudio estará integrada por 76 profesionales enfermeros que prestan servicio netamente asistencial en el servicio de centro quirúrgico del Hospital de la Policía Nacional del Perú, los que han sido obtenidos de acuerdo con la aplicación de la fórmula de la muestra probabilística, y los que cumplirán estrictamente con los criterios de exclusión e inclusión establecidos. En cuanto a la técnica de relevamiento de data se aplicará la encuesta, ejecutada en un solo momento, mediante los instrumentos denominados Escala de Maslach y Escala de Calidad de Vida Profesional (CPV -38), para la variable estrés laboral y calidad de vida profesional respectivamente. Respecto del tratamiento de la data obtenida se efectuará mediante el programa Microsoft Excel versión 9 para su clasificación, organización y respectivo control de calidad; posteriormente se exportará al software SPSS versión 24.0 para ejecutar los cálculos estadísticos correspondientes, y así desarrollar tablas y gráficos para el análisis de las variables exploradas.
Acceso abierto
Estudio de utilización del ciprofloxacino en infección del tracto urinario no complicado en pacientes adultos atendidos por el Seguro Integral de Salud del Hospital Vitarte. Julio 2016 a Junio 2017
(Universidad Privada Norbert Wiener, 2020-02-25) Sánchez Paredes, José Luis; Herencia Torres, Victor Reynaldo
Antibiotics are highly important due to their therapeutic, clinical, social, and economic benefits. Their rational use is crucial to prevent resistance and side effects that diminish their value, which is why this study was proposed. Objective: To evaluate the drug utilization study of Ciprofloxacin in uncomplicated Urinary Tract Infections (UTI) in adult patients covered by the Comprehensive Health Insurance (SIS) at the Vitarte Hospital, from July 2016 to June 2017. Methodology: A descriptive, observational, and retrospective study was conducted over a 12-month period, analyzing Ciprofloxacin consumption in uncomplicated UTI, Prescription-Indication criteria, and the Quality of Indication-Prescription. Results: A maximum Ciprofloxacin consumption of 2.2 DDD was observed in the study. Ciprofloxacin ranked second and fourth for prescription-indication in UTIs, and it was observed that 95.7% (202) of use was inappropriate. Conclusions: The drug utilization study of Ciprofloxacin 500 mg tablets in uncomplicated UTI revealed a growing consumption and a high percentage of inappropriate use.
Acceso abierto
Evaluación de cumplimiento de las buenas prácticas de oficinas farmacéuticas de la Av. Próceres de la Independencia, San Juan de Lurigancho 2021–2022
(Universidad Privada Norbert Wiener, 2022-07-08) Romero Callupe, Ricardo Jhon Manuel; Villanueva Anlas, Katherine Maria; Ramos Jaco, Antonio Guillermo
The objective was to evaluate compliance with good pharmaceutical office practices on Av. Próceres de la Independencia in San Juan de Lurigancho. In this research, a deductive, descriptive-analytical method was chosen, with a basic quantitative approach and a non-experimental, descriptive, and cross-sectional design. The sample consisted of 26 pharmaceutical establishments, where a checklist instrument with 29 items across four dimensions was applied. Its reliability, measured by Cronbach's alpha, was 0.876. Results: 62% of the establishments achieved a high level of compliance with the requirements for staff knowledge, experience, and responsibility. 62% also reported a high level of compliance in the dimension of adequate infrastructure, furniture, and equipment. Additionally, 31% of the establishments had a high level of compliance regarding required documentation. Finally, it was demonstrated that all evaluated establishments have a Certification of Good Pharmaceutical Office Practices. Conclusion: 54% of the pharmaceutical establishments comply with good pharmaceutical office practices.
Acceso abierto
Evaluación de la calidad de los envases de plástico usados en la industria farmacéutica
(Universidad Privada Norbert Wiener, 2021-08-13) Andrade Huallpa, Mercedes Belen; Jaramillo Briceño, Marilú Ricardina
This research was developed with the objective of describing the analyses performed to evaluate the quality of plastic containers used in the pharmaceutical industry. Materials and methods: This research is of a basic, descriptive, comparative, and quantitative type, with a non-experimental design based on a review of bibliographic information. The instrument was validated by three experts, and tables and graphs in Excel were used for the statistical analysis. Results: The quality characteristics of plastic containers used in the pharmaceutical industry were evaluated through dimensional analysis, functional analysis, performance analysis, and identification analysis. Conclusions: Based on the reviewed research, the majority of plastic containers used in the pharmaceutical industry comply with the required characteristics, and the analyses performed to evaluate their quality are dimensional analysis, functional analysis, performance analysis, and identification analysis.
Acceso abierto
Evaluación de la irritabilidad ocular in vitro mediante el método HET-CAM en cremas para contorno de ojos con y sin registro sanitario que se comercializan en el distrito de La Victoria, La Parada – Lima
(Universidad Privada Norbert Wiener, 2018-06-04) Celestino Ramirez, Fiorela Victoria; Llacsa Quispe, Luz Marina; Lizano Gutiérrez, Jesús Víctor
This research provides scientific data on the qualitative HET-CAM and quantitative HET-CAM (CAM-TBS) methods for evaluating eye contour cosmetic creams with and without sanitary registration. The objective is to compare the level of irritability of eye contour creams with and without sanitary registration from different brands. A total of 30 creams with sanitary registration and 30 creams without sanitary registration were analyzed. These creams were acquired in the La Victoria district (Parada), due to demand from beauty and personal hygiene product distributors. The analyses were performed in the laboratory of the Faculty of Pharmacy and Biochemistry at Norbert Wiener University (UNW). Methodology is based on Protocol No. 108 of the in vitro techniques in Toxicology (INVITTOX), which consists of studying the reaction of assay variants on the chorioallantoic membrane of the hen's egg for the evaluation of ocular irritation. Results: The potential irritation results for ten eye contour cream formulations indicate that creams without sanitary registration are highly irritating to the eyes, posing an 80% risk for the people who use them, while creams with sanitary registration have low irritability and represent a 10% risk.